Journal of Assisted Reproduction and Genetics

, Volume 35, Issue 3, pp 441–447 | Cite as

Cumulative pregnancy and live birth rates through assisted reproduction in women 44–45 years of age: is there any hope?

  • Nili Raz
  • Amir Shalev
  • Eran Horowitz
  • Ariel Weissman
  • Yossi Mizrachi
  • Hadass Ganer Herman
  • Arieh Raziel
Assisted Reproduction Technologies



The purpose of the study is to calculate the cumulative pregnancy rate and cumulative live birth rate in women undergoing in vitro fertilization (IVF) at ages 44–45.


The study calculated cumulative live pregnancy rate and cumulative live birth rate of 124 women aged 44 to 45 years old who commenced IVF treatment.

Main outcome measures

The main outcome measures are cumulative live pregnancy rate and cumulative live birth rate.


Cumulative live pregnancy rates following 1, 2, 3, and 4 cycles were 5.6, 11, 17, and 20%, respectively, with no additional pregnancies in further cycles. Cumulative live birth rates following 1, 2, and 3 cycles were 1.6, 3, and 7%, respectively, with no additional live births in further cycles.


The cumulative pregnancy rate rises during the first 4 cycles and cumulative live birth rate rises during the first 3 cycles, with no additional rise in pregnancies or deliveries thereafter, suggesting that it is futile to offer more than 3 cycles of treatment to 44–45-year-old women.


Assisted reproductive technology Low ovarian reserve Cumulative pregnancy rate Cumulative live birth rate 


Compliance with ethical standards

Ethical approval for this study was provided by a local Helsinki committee at Wolfson Medical Center.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  1. 1.IVF Unit, Department of Obstetrics and GynecologyEdith Wolfson Medical CenterHolonIsrael
  2. 2.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Department of Obstetrics and GynecologyHillel Yaffe Medical CenterHaderaIsrael
  4. 4.The Ruth and Bruce Rappaport Faculty of Medicine, TechnionHaifaIsrael

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