Cumulative pregnancy and live birth rates through assisted reproduction in women 44–45 years of age: is there any hope?
The purpose of the study is to calculate the cumulative pregnancy rate and cumulative live birth rate in women undergoing in vitro fertilization (IVF) at ages 44–45.
The study calculated cumulative live pregnancy rate and cumulative live birth rate of 124 women aged 44 to 45 years old who commenced IVF treatment.
Main outcome measures
The main outcome measures are cumulative live pregnancy rate and cumulative live birth rate.
Cumulative live pregnancy rates following 1, 2, 3, and 4 cycles were 5.6, 11, 17, and 20%, respectively, with no additional pregnancies in further cycles. Cumulative live birth rates following 1, 2, and 3 cycles were 1.6, 3, and 7%, respectively, with no additional live births in further cycles.
The cumulative pregnancy rate rises during the first 4 cycles and cumulative live birth rate rises during the first 3 cycles, with no additional rise in pregnancies or deliveries thereafter, suggesting that it is futile to offer more than 3 cycles of treatment to 44–45-year-old women.
KeywordsAssisted reproductive technology Low ovarian reserve Cumulative pregnancy rate Cumulative live birth rate
Compliance with ethical standards
Ethical approval for this study was provided by a local Helsinki committee at Wolfson Medical Center.