Journal of Assisted Reproduction and Genetics

, Volume 34, Issue 11, pp 1469–1474 | Cite as

A transportation network for human ovarian tissue is indispensable to success for fertility preservation

  • K Kyono
  • T Hashimoto
  • M Toya
  • M Koizumi
  • C Sasaki
  • S Shibasaki
  • N Aono
  • Y Nakamura
  • R Obata
  • N Okuyama
  • Y Ogura
  • H Igarashi
Fertility Preservation
  • 102 Downloads

Abstract

Purpose

The purpose of this study was to examine the efficacy of an ovarian tissue transportation network for fertility preservation (FP) for cancer patients in Japan.

Methods

PubMed was searched for papers on transportation of human ovarian tissue for FP. We analyzed population, area, number of cancer patients for ovarian tissue cryopreservation (OTC), quality control/assessment and safety, cost of a cryopreservation center for the building for 30 years, and medical fees of cancer patients (operation, cryopreservation, and storage of ovarian tissue).

Results

More than twenty babies have been born in Denmark and Germany through a transportation system. Up to 400 new patients a year need OTC. The fees for removal, cryopreservation, and storage for 5 years, and transplantation of ovarian tissue are around €5,000, €4,000, and €5,000, respectively. It costs more than €5 million to establish and maintain one cryopreservation center for 30 years. If we have a few cryopreservation centers in Japan, we can cryopreserve 400 patients’ ovarian tissue per year by safer slow freezing and maintain quality control/assessment. We need to lighten the patients’ burden for easy to use FP by a government subsidy and medical insurance coverage.

Conclusions

This model has been termed the Danish model (“the woman stays - the tissue moves”). This is truly patient-centered medicine. We can have maximum effects with the minimum burden. A transportation network like those of Denmark and Germany is the best strategy for FP in Japan. It may be the best system for cancer patients, medical staff, and the Ministry of Health, Labor, and Welfare.

Keywords

Fertility preservation Transportation Human ovarian tissue Cryopreservation Network 

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • K Kyono
    • 1
    • 2
  • T Hashimoto
    • 1
    • 2
  • M Toya
    • 1
    • 2
  • M Koizumi
    • 1
    • 2
  • C Sasaki
    • 1
    • 2
  • S Shibasaki
    • 1
    • 2
  • N Aono
    • 1
    • 2
  • Y Nakamura
    • 1
    • 2
  • R Obata
    • 1
    • 2
  • N Okuyama
    • 1
    • 2
  • Y Ogura
    • 1
    • 2
  • H Igarashi
    • 1
    • 2
  1. 1.Kyono ART Clinic TakanawaTokyoJapan
  2. 2.Kyono ART ClinicSendaiJapan

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