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Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos

  • Embryo Biology
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

This study aimed to test whether there is an association between embryo morphokinetic parameters and ploidy status.

Methods

Patients with high risk of aneuploidy were analyzed by time-lapse microscopy combined with preimplantation genetic screening (PGS). Accordingly, 256 blastocysts from 75 patients were subjected to trophectoderm biopsy and microarray comparative genomic hybridization (array-CGH). Blastocyst development process was analyzed using time-lapse images.

Results

Morphokinetic parameters: tPNf, t2, t3, t4, t5, t8, t9, tcom, tM, tSB, tB, tEB, CC1, CC2, CC3, S2, S3, t5-t2, and tB-tSB showed no significant difference in euploid embryos compared to aneuploid counterparts. In addition, two risk models based on previously published morphokinetic parameters failed to segregate euploid from aneuploid embryos.

Conclusions

Morphokinetic parameters subjected to investigation in the present study failed to improve the chance of selecting euploid embryos.

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Acknowledgement

This research was funded by National Research and Development Plan (2016YFC1000600) and Major Program of National Natural Science Foundation of China (8149073).

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Authors and Affiliations

  1. Center for Reproductive Medicine, Shandong University, 157 Jingliu Road, Jinan, 250021, China

    Jingye Zhang, Wenrong Tao, Hui Liu, Guanling Yu, Mei Li, Shuiying Ma & Keliang Wu

  2. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China

    Jingye Zhang, Wenrong Tao, Hui Liu, Guanling Yu, Mei Li, Shuiying Ma & Keliang Wu

  3. The Key laboratory for Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, China

    Jingye Zhang, Wenrong Tao, Hui Liu, Guanling Yu, Mei Li, Shuiying Ma & Keliang Wu

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  1. Jingye Zhang
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  2. Wenrong Tao
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  3. Hui Liu
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  4. Guanling Yu
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Correspondence to Keliang Wu.

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Zhang, J., Tao, W., Liu, H. et al. Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos. J Assist Reprod Genet 34, 1173–1178 (2017). https://doi.org/10.1007/s10815-017-0965-8

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  • DOI: https://doi.org/10.1007/s10815-017-0965-8

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