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Ovarian hyperstimulation syndrome following GnRH agonist trigger—think ectopic

  • Assisted Reproduction Technologies
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Abstract

Purpose

This study aims to report a case of ovarian hyperstimulation syndrome (OHSS) following GnRH agonist trigger for final follicular maturation.

Methods

This study is a retrospective chart review.

Results

We report the first case of OHSS following GnRH agonist trigger for final follicular maturation and freeze-all, masking extrauterine pregnancy (EUP). The present case report elucidates the feasibility of stimulating and recruiting ovarian follicles yielding mature oocytes during early pregnancy and the ability of GnRH agonist to trigger final follicular maturation during pregnancy, in the presence of high progesterone and hCG levels.

Conclusions

Since OHSS almost always develops after hCG administration or in early pregnancy, its occurrence following GnRH agonist trigger should alert physician to search for either an inadvertent administration of exogenous hCG, or the endogenous secretion of hCG by pregnancy, e.g. EUP, or as part of a paraneoplastic syndrome.

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Acknowledgments

The authors would like to thank the “Memorial Fund Griffini Miglierina” within the “Fondazione Comunitaria del Varesotto Onlus” for non-restricted financial support to Dr. VSV during the completion of the study.

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Authors and Affiliations

  1. Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel

    Raoul Orvieto & Valeria Stella Vanni

  2. Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Raoul Orvieto

  3. Centro Scienze Natalità, Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, Milan, Italy

    Valeria Stella Vanni

Authors
  1. Raoul Orvieto
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  2. Valeria Stella Vanni
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Corresponding author

Correspondence to Raoul Orvieto.

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Orvieto, R., Vanni, V.S. Ovarian hyperstimulation syndrome following GnRH agonist trigger—think ectopic. J Assist Reprod Genet 34, 1161–1165 (2017). https://doi.org/10.1007/s10815-017-0960-0

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  • DOI: https://doi.org/10.1007/s10815-017-0960-0

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