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Adiponectin and leptin gene polymorphisms in women with gestational diabetes mellitus

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

Gestational diabetes mellitus (GDM) is the glucose intolerance occurring during pregnancy. The prevalence of GDM is increased in obese women. Leptin and adiponectin are adipokines that play an important role in the regulation of insulin secretion and glucose and lipid metabolism. The aim of this study was to examine the association between adiponectin and leptin gene polymorphisms and the development of GDM.

Methods

This case–control study included 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT). The diagnosis of GDM was based on a 75-g oral glucose tolerance test (OGTT) at 24–28 weeks’ gestation. To discriminate the ADIPOQ rs266729, rs1501299 and LEP rs2167270 alleles, TaqMan® Pre-Designed SNP Genotyping Assays were used.

Results

There was a statistically significant association between the ADIPOQ rs266729 gene polymorphism and GDM. Among women with GDM, a higher prevalence of the G allele was observed (GG and CG genotypes). Multivariate logistic regression analysis, taking into account age, BMI before pregnancy, past pregnancies and the ADIPOQ rs266729 gene polymorphism, revealed that the presence of a G allele is an independent risk factor for GDM. Moreover, there was the association between the LEP rs2167270 polymorphism and the requirement for daily insulin, which was significantly higher in women with the A allele (AA and GA genotypes).

Conclusions

The results of our study suggest an association between adiponectin gene rs266729 as well as leptin gene rs2167270 polymorphisms and GDM.

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Author information

Authors and Affiliations

  1. Department of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111, Szczecin, Poland

    Andrzej Pawlik

  2. Department of Obstetrics and Gynecology, County Hospital, Zielona Gora, Poland

    Joanna Teler

  3. Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland

    Agnieszka Maciejewska & Marek Sawczuk

  4. Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland

    Krzysztof Safranow & Violetta Dziedziejko

Authors
  1. Andrzej Pawlik
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  2. Joanna Teler
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  3. Agnieszka Maciejewska
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  4. Marek Sawczuk
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  5. Krzysztof Safranow
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  6. Violetta Dziedziejko
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Corresponding author

Correspondence to Andrzej Pawlik.

Ethics declarations

The study was approved by the ethics committee in Pomeranian Medical University, Szczecin, Poland, and written informed consent was obtained from all subjects.

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The authors declare that they have no conflict of interest.

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Capsule

This study examined the association between adiponectin and leptin gene polymorphisms and the development of GDM.

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Pawlik, A., Teler, J., Maciejewska, A. et al. Adiponectin and leptin gene polymorphisms in women with gestational diabetes mellitus. J Assist Reprod Genet 34, 511–516 (2017). https://doi.org/10.1007/s10815-016-0866-2

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  • DOI: https://doi.org/10.1007/s10815-016-0866-2

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