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The association between multinucleated blastomeres and poor ovarian response under the Bologna criteria

Journal of Assisted Reproduction and Genetics volume 33, pages 885–892 (2016)Cite this article

Abstract

Purpose

To investigate the occurrence of multinucleated blastomeres (MNB) in poor ovarian response (POR) women defined under the Bologna criteria.

Methods

This observational study was designed in a prospective controlled manner. Among 380 cases evaluated for eligibility, 102 women were found suitable and recruited; 51 with POR in accordance with the Bologna criteria defined as the study group and 51 with normal ovarian response defined as the control group.

Results

Among the 51 women in each group, 8 and 2 did not achieve embryos in the study and control group, respectively (P < 0.05). The percentage of women that had at least one embryo with one MNB was significantly higher in the study as compared to the control group, corresponding to 49 and 29 %, respectively. The total number of embryos evaluated was 416; 167 in the study and 249 in the control groups. Among these embryos, the MNB rate was significantly higher in the study as compared to the control group, corresponding to 19 and 8 %, respectively.

Conclusions

Blastomere multinuclearity is significantly more common in women and embryos of POR cases, defined under the Bologna criteria. Future studies are warranted to substantiate our observation that has the potential to be clinically implemented in this sub-group of women undergoing assisted reproductive technologies (ART) treatment.

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Author information

Affiliations

  1. Reproductive Medicine Unit, Department of Obstetrics & Gynecology, Poriya Medical Center, Tiberias, 15208, Israel

    Johnny S. Younis, Vicky Yazdi & Moshe Ben-Ami

  2. Faculty of Medicine in Galilee, Bar-Ilan University, Safed, Israel

    Johnny S. Younis & Moshe Ben-Ami

  3. Department of Evolutionary and Environmental Biology, University of Haifa, Haifa, Israel

    Ido Izhaki

Authors
  1. Johnny S. Younis
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  2. Vicky Yazdi
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  3. Ido Izhaki
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  4. Moshe Ben-Ami
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Corresponding author

Correspondence to Johnny S. Younis.

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Capsule

Blastomere multinuclearity is significantly more common in women and embryos of POR cases, defined under the Bologna criteria.

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Cite this article

Younis, J.S., Yazdi, V., Izhaki, I. et al. The association between multinucleated blastomeres and poor ovarian response under the Bologna criteria. J Assist Reprod Genet 33, 885–892 (2016). https://doi.org/10.1007/s10815-016-0731-3

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  • DOI: https://doi.org/10.1007/s10815-016-0731-3

Keywords

  • Assisted reproductive technologies
  • Bologna criteria
  • Multinucleated blastomere
  • Ovarian reserve
  • Poor ovarian response