Journal of Assisted Reproduction and Genetics

, Volume 32, Issue 8, pp 1167–1170 | Cite as

Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice

  • Jacques Donnez
  • Marie-Madeleine Dolmans
Fertility Preservation


This paper describes the success and expansion of ovarian tissue cryopreservation and transplantation as a fertility restoration procedure, with the largest series of 60 live births worldwide reported. By repeating the procedure, ovarian activity can be restored for more than 11 years.


Ovarian tissue transplantation Live births Fertility preservation Cancer patients 


  1. 1.
    Donnez J, Dolmans MM. Fertility preservation in women. Nat Rev Endocrinol. 2013;9:735–49.CrossRefPubMedGoogle Scholar
  2. 2.
    Cobo A, Garcia-Velasco JA, Domingo J, Remohí J, Pellicer A. Is vitrification of oocytes useful for fertility preservation for age-related fertility decline and in cancer patients? Fertil Steril. 2013;99(6):1485–95.CrossRefPubMedGoogle Scholar
  3. 3.
    Donnez J, Dolmans MM. Ovarian tissue freezing: current status. Curr Opin Obstet Gynecol. 2015;27(3):222–30.CrossRefPubMedGoogle Scholar
  4. 4.
    Jadoul P, Dolmans MM, Donnez J. Fertility preservation in girls during childhood: is it feasible, efficient and safe and to whom should it be proposed? Hum Reprod Update. 2010;16(6):617–30.CrossRefPubMedGoogle Scholar
  5. 5.
    Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med. 2005;353(3):318–21.CrossRefPubMedGoogle Scholar
  6. 6.
    Andersen CY, Rosendahl M, Byskov AG, Loft A, Ottosen C, Dueholm M, et al. Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod. 2008;23(10):2266–72.CrossRefPubMedGoogle Scholar
  7. 7.
    Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364(9443):1405–10.CrossRefPubMedGoogle Scholar
  8. 8.
    Donnez J, Jadoul P, Pirard C, Hutchings G, Demylle D, Squifflet J, et al. Live birth after transplantation of frozen-thawed ovarian tissue after bilateral oophorectomy for benign disease. Fertil Steril. 2012;98(3):720–5.CrossRefPubMedGoogle Scholar
  9. 9.
    Donnez J, Dolmans MM, Pellicer A, Diaz-Garcia C, Sanchez Serrano M, Schmidt KT, et al. Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation. Fertil Steril. 2013;99(6):1503–13.CrossRefPubMedGoogle Scholar
  10. 10.
    Donnez J, Dolmans MM, Pellicer A, Diaz-Garcia C, Ernst E, Macklon KT, et al. Fertility preservation for age-related fertility decline. Lancet. 2015;385(9967):506–7.CrossRefPubMedGoogle Scholar
  11. 11.
    Andersen CY. Success and challenges in fertility preservation after ovarian tissue grafting. Lancet. 2015;385(9981):1947–8.CrossRefPubMedGoogle Scholar
  12. 12.
    Prasath EB, Chan ML, Wong WH, Lim CJ, Tharmalingam MD, Hendricks M, et al. First pregnancy and live birth resulting from cryopreserved embryos obtained from in vitro matured oocytes after oophorectomy in an ovarian cancer patient. Hum Reprod. 2014;29(2):276–8.CrossRefPubMedGoogle Scholar
  13. 13.
    Segers I, Mateizel I, Guzman L, Romero S, Van Moer E, Smitz J, et al. Congress on “Freezing oocytes embryos and ovarian tissue”. Brussels; 2015.Google Scholar
  14. 14.
    Dolmans MM, Marotta ML, Pirard C, Donnez J, Donnez O. Ovarian tissue cryopreservation followed by controlled ovarian stimulation and pick-up of mature oocytes does not impair the number or quality of retrieved oocytes. J Ovarian Res. 2014;7:80.PubMedCentralCrossRefPubMedGoogle Scholar
  15. 15.
    Dolmans MM, Jadoul P, Gilliaux S, Amorim CA, Luyckx V, Squifflet J, et al. A review of 15 years of ovarian tissue bank activities. J Assist Reprod Genet. 2013;30(3):305–14.PubMedCentralCrossRefPubMedGoogle Scholar
  16. 16.
    Rozen G, Agresta F, Gook D, Braat D, Stern CJ. Success and challenges in fertility preservation after ovarian tissue grafting. Lancet. 2015;385(9981):1947.CrossRefPubMedGoogle Scholar
  17. 17.
    Rodriguez-Wallberg KA, Karlström PO, Rezapour M, Castellanos E, Hreinsson J, Rasmussen C, et al. Full-term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy. Acta Obstet Gynecol Scand. 2015;94(3):324–8.CrossRefPubMedGoogle Scholar
  18. 18.
    Tanbo T, Greggains G, Storeng R, Busund B, Langebrekke A, Fedorcsak P. Autotransplantation of cryopreserved ovarian tissue after treatment for malignant disease - the first Norwegian results. Acta Obstet Gynecol Scand. 2015. [Epub ahead of print].Google Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.SRI, Société de Recherche pour l’InfertilitéBrusselsBelgium
  2. 2.Pôle de Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, and Gynaecology DepartmentCliniques Universitaires St LucBrusselsBelgium

Personalised recommendations