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Laparoscopic excision of ovarian endometrioma does not exert a qualitative effect on ovarian function: insights from in vitro fertilization and single embryo transfer cycles

  • Miyuki HaradaEmail author
  • Nozomi Takahashi
  • Tetsuya Hirata
  • Kaori Koga
  • Tomoyuki Fujii
  • Yutaka Osuga
Assisted Reproduction Technologies

Abstract

Purpose

To evaluate whether laparoscopic excision of endometrioma exerts a qualitative effect on ovarian function.

Methods

A retrospective analysis of oocytes retrieved in 25 cycles of 21 patients undergoing IVF treatment with controlled ovarian stimulation. The number of oocytes recovered from ovaries with a history of excision of endometrioma (E-Ov) were compared to those from contra-lateral healthy ovaries (H-Ov) as for the analysis of a quantitative effect of surgery. As for the analysis of a qualitative effect, 55 oocytes from E-Ov were compared to 128 oocytes from H-Ov in terms of normal fertilization rate and the rate of top-quality embryos per normally fertilized eggs. Furthermore, 10 embryos derived from oocytes recovered from E-Ov were compared to 24 embryos derived from oocytes from H-Ov in terms of clinical and on-going pregnancy rates per embryos in 34 single embryo transfer cycles.

Results

Mean number of oocytes recovered from E-Ov was significantly smaller than that from H-Ov (2.2 ± 2.0 vs. 5.1 ± 3.3, P = 0.009). There was no difference between oocytes from E-Ov and H-Ov as for normal fertilization rate (63.6 % vs. 69.5 %, P = 0.43) and the rate of top-quality embryos (40.0 % vs. 49.0 %, P = 0.34). Clinical and on-going pregnancy rates per embryos were also similar in embryos derived from oocytes recovered from E-Ov and H-Ov (40.0 % vs. 25.0 %, P = 0.39 and 20.0 % vs. 20.8 %, P = 0.96).

Conclusions

The quality of oocytes recovered from the ovary with a history of laparoscopic excision of endometrioma is not inferior to the quality of oocytes from contra-lateral healthy ovary.

Keywords

Laparoscopic excision Ovarian endometrioma Ovarian function In vitro fertilization Oocyte Single embryo transfer 

Notes

Acknowledgments

Authors thank to patients and staff, especially Ms. Nagisa Oi, at the IVF center in University of Tokyo Hospital. Authors also thank to Dr. Akihisa Fujimoto, Dr. Hajime Oishi, Dr. Masashi Takamura, and Dr. Gentaro Izumi for their valuable comments.

Compliance with ethical standards

Funding

This work was supported by Grant-in-Aids for Scientific Research from Japan Society for the Promotion of Science.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Miyuki Harada
    • 1
    Email author
  • Nozomi Takahashi
    • 1
  • Tetsuya Hirata
    • 1
  • Kaori Koga
    • 1
  • Tomoyuki Fujii
    • 1
  • Yutaka Osuga
    • 1
  1. 1.Department of Obstetrics and Gynecology, Faculty of MedicineUniversity of TokyoTokyoJapan

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