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Perinatal outcomes in singleton and twin ICSI pregnancies following hysteroscopic correction of partial intrauterine septa

  • Assisted Reproduction Technologies
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Abstract

Purpose

To investigate the perinatal outcomes of patients with clinical pregnancies from ICSI treatments who had previously undergone hysteroscopic surgery to correct partial intrauterine septa and compare them to outcomes of patients with no intrauterine anomalies.

Method

A retrospective observational analysis of 2024 ultrasound confirmed pregnancies from ICSI treatments performed between January 2005 and June 2012. The patients were grouped according to their intrauterine status, and sub-grouped according to the number of fetal hearts observed; singleton control (n = 1128), twin control (n = 566), singleton septum (n = 217) and twin septum (n = 113). The primary outcomes analyzed were miscarriage, preterm, very preterm, stillbirth, vanishing twin and live delivery rates, as well as low birth weight and very low birth weight rates.

Result(s)

The live birth rate (89,9 %) in the singleton control subgroup was non-significantly higher than the live birth rate (85,3 %) in the septum subgroup, with a RR of 1,05 (p = 0,0583, 95 % CI 0,9943–1,1182) for live birth. In contrast the live birth rate (91,3 %) in twin control subgroup was significantly higher than the live birth rate (84,1 %) in the septum subgroup, with a RR 1,09 (p = 0,0282, 95 % CI 0,9988–1,1819). Non-significantly, higher miscarriage and stillbirth rates were the main contributors to the reduced live birth rates. The singleton and twin septum subgroups also had higher rates of premature and very premature delivery and LBWs and vLBW, especially in the singleton septum subgroup.

Conclusion(s)

The hysteroscopic correction of intrauterine septa may not eliminate all risks for premature delivery.

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Study funding/competing interest(s)

The study was performed and manuscript prepared with no known conflicts of interest and with no financial support.

Author information

Authors and Affiliations

  1. Antalya IVF, Halide Edip Cd. No:7, Kanal Mh, Antalya, 07080, Turkey

    Kemal Ozgur, Hasan Bulut & Murat Berkkanoglu

  2. Vitale, Kadin Hastalıkları ve Doğum Hastanesi, Antalya, Turkey

    Kevin Coetzee

Authors
  1. Kemal Ozgur
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  2. Hasan Bulut
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  3. Murat Berkkanoglu
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  4. Kevin Coetzee
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Corresponding author

Correspondence to Kemal Ozgur.

Additional information

Capsule

While hysteroscopic correction of partial septa may significantly reduce adverse perinatal outcomes, some losses most probably attributable to the pre-existance of intrauterine septa may persist, especially in cases of twin pregnancy.

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Ozgur, K., Bulut, H., Berkkanoglu, M. et al. Perinatal outcomes in singleton and twin ICSI pregnancies following hysteroscopic correction of partial intrauterine septa. J Assist Reprod Genet 32, 533–541 (2015). https://doi.org/10.1007/s10815-015-0444-z

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  • DOI: https://doi.org/10.1007/s10815-015-0444-z

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