Skip to main content

Blood type predicts live birth in the infertile population

Abstract

Purpose

To determine if blood type in infertile women relates to the likelihood for live birth (LB) following IVF, and to the etiology for infertility.

Methods

Retrospective study of patients undergoing IVF at two academic centers in the northeast US. Relationships between blood type (A, B, AB, O) and patient characteristics, IVF cycle parameters and LB were assessed utilizing multivariable logistic regression analyses.

Results

In the studied population (n = 626), women with type O were significantly more likely to have baseline FSH > 10 IU/L after adjusting for age, BMI and race (OR 5.09, 95 % CI 1.4–18.7, p = 0.01). Conversely, women with blood type A were significantly more likely to have ovulatory infertility compared to those with blood type O after adjusting for age and BMI (OR 3.2, 95 % CI 1.7–6.2). Blood type B was associated with increased likelihood of live birth (OR 1.9, 95 % CI 1.10–3.41, p = 0.03) after adjusting for factors recognized to impact IVF outcome.

Conclusion

Ovulatory infertility and baseline FSH > 10 IU/L were more prevalent in women with blood type A and O respectively. However, those of blood type B had significantly higher odds for LB compared to other blood types after adjusting for factors recognized to impact on IVF cycle outcome. While underlying mechanisms are unclear, for infertile women, patient’s blood type is seemingly relevant for IVF cycle outcome.

This is a preview of subscription content, access via your institution.

Fig. 1

References

  1. 1.

    Binder H, Flegel WA, Emran J, Muller A, Cupisti S, Beckmann MW, et al. Blood group A: an overseen risk factor for early-onset ovarian hyperstimulation syndrome? Reprod Biomed Online. 2008;17:185–9.

    Article  PubMed  Google Scholar 

  2. 2.

    Binder H, Flegel WA, Emran J, Muller A, Dittrich R, Beckmann MW, et al. Association of blood group A with early-onset ovarian hyperstimulation syndrome. Transfus Clin Biol. 2008;15:395–401.

    Article  CAS  PubMed  Google Scholar 

  3. 3.

    Yuzhalin AE, Kutikhin AG. ABO and Rh blood groups in relation to ovarian, endometrial and cervical cancer risk among the population of South-East Siberia. Asian Pac J Cancer Prev: APJCP. 2012;13:5091–6.

    Article  PubMed  Google Scholar 

  4. 4.

    Matalliotakis I, Cakmak H, Goumenou A, Sifakis S, Ziogos E, Arici A. ABO and Rh blood groups distribution in patients with endometriosis. Arch Gynecol Obstet. 2009;280:917–9.

    Article  PubMed  Google Scholar 

  5. 5.

    Nejat EJ, Jindal S, Berger D, Buyuk E, Lalioti M, Pal L. Implications of blood type for ovarian reserve. Hum Reprod. 2011;26:2513–7.

    Article  PubMed  Google Scholar 

  6. 6.

    Garratty G, Glynn SA, McEntire R. ABO and Rh(D) phenotype frequencies of different racial/ethnic groups in the United States. Transfusion. 2004;44:703–6.

    Article  PubMed  Google Scholar 

  7. 7.

    Rosenwaks Z, Davis OK, Damario MA. The role of maternal age in assisted reproduction. Hum Reprod. 1995;10 Suppl 1:165–73.

    Article  PubMed  Google Scholar 

  8. 8.

    Scott Jr RT, Hofmann GE. Prognostic assessment of ovarian reserve. Fertil Steril. 1995;63:1–11.

    PubMed  Google Scholar 

  9. 9.

    Scott RT, Opsahl MS, Leonardi MR, Neall GS, Illions EH, Navot D. Life table analysis of pregnancy rates in a general infertility population relative to ovarian reserve and patient age. Hum Reprod. 1995;10:1706–10.

    CAS  PubMed  Google Scholar 

  10. 10.

    Sharara FI, Scott Jr RT, Seifer DB. The detection of diminished ovarian reserve in infertile women. Am J Obstet Gynecol. 1998;179:804–12.

    Article  CAS  PubMed  Google Scholar 

  11. 11.

    Levi AJ, Raynault MF, Bergh PA, Drews MR, Miller BT, Scott Jr RT. Reproductive outcome in patients with diminished ovarian reserve. Fertil Steril. 2001;76:666–9.

    Article  CAS  PubMed  Google Scholar 

  12. 12.

    Broekmans FJ, Kwee J, Hendriks DJ, Mol BW, Lambalk CB. A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update. 2006;12:685–718.

    Article  CAS  PubMed  Google Scholar 

  13. 13.

    Timberlake KS, Foley KL, Hurst BS, Matthews ML, Usadi RS, Marshburn PB. Association of blood type and patient characteristics with ovarian reserve. Fertil Steril. 2013;100:1735–9.

    Article  PubMed  Google Scholar 

  14. 14.

    Yamamoto F, Clausen H, White T, Marken J, Hakomori S. Molecular genetic basis of the histo-blood group ABO system. Nature. 1990;345:229–33.

    Article  CAS  PubMed  Google Scholar 

  15. 15.

    Palcic MM, Seto NO, Hindsgaul O. Natural and recombinant A and B gene encoded glycosyltransferases. Transfus Med. 2001;11:315–23.

    Article  CAS  PubMed  Google Scholar 

  16. 16.

    Bungum L, Jacobsson AK, Rosen F, Becker C, Yding Andersen C, Guner N, et al. Circadian variation in concentration of anti-Mullerian hormone in regularly menstruating females: relation to age, gonadotrophin and sex steroid levels. Hum Reprod. 2011;26:678–84.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgment

The authors would like to thank Edward Nejat.

Study funding

None.

Conflict of interest

None of the authors has any conflict of interest to declare.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Sangita K. Jindal.

Additional information

Capsule In an infertile population, we observed that blood type B was associated with increased likelihood of live birth.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Goldsammler, M., Jindal, S.K., Kallen, A. et al. Blood type predicts live birth in the infertile population. J Assist Reprod Genet 32, 551–555 (2015). https://doi.org/10.1007/s10815-015-0441-2

Download citation

Keywords

  • Blood type
  • Infertility
  • Ovulatory dysfunction
  • Live birth
  • IVF