Journal of Assisted Reproduction and Genetics

, Volume 32, Issue 4, pp 551–555 | Cite as

Blood type predicts live birth in the infertile population

  • Michelle Goldsammler
  • Sangita K. Jindal
  • Amanda Kallen
  • Natu Mmbaga
  • Lubna Pal
Assisted Reproduction Technologies



To determine if blood type in infertile women relates to the likelihood for live birth (LB) following IVF, and to the etiology for infertility.


Retrospective study of patients undergoing IVF at two academic centers in the northeast US. Relationships between blood type (A, B, AB, O) and patient characteristics, IVF cycle parameters and LB were assessed utilizing multivariable logistic regression analyses.


In the studied population (n = 626), women with type O were significantly more likely to have baseline FSH > 10 IU/L after adjusting for age, BMI and race (OR 5.09, 95 % CI 1.4–18.7, p = 0.01). Conversely, women with blood type A were significantly more likely to have ovulatory infertility compared to those with blood type O after adjusting for age and BMI (OR 3.2, 95 % CI 1.7–6.2). Blood type B was associated with increased likelihood of live birth (OR 1.9, 95 % CI 1.10–3.41, p = 0.03) after adjusting for factors recognized to impact IVF outcome.


Ovulatory infertility and baseline FSH > 10 IU/L were more prevalent in women with blood type A and O respectively. However, those of blood type B had significantly higher odds for LB compared to other blood types after adjusting for factors recognized to impact on IVF cycle outcome. While underlying mechanisms are unclear, for infertile women, patient’s blood type is seemingly relevant for IVF cycle outcome.


Blood type Infertility Ovulatory dysfunction Live birth IVF 



The authors would like to thank Edward Nejat.

Study funding


Conflict of interest

None of the authors has any conflict of interest to declare.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Michelle Goldsammler
    • 1
  • Sangita K. Jindal
    • 1
    • 3
  • Amanda Kallen
    • 2
  • Natu Mmbaga
    • 2
  • Lubna Pal
    • 2
  1. 1.Reproductive Endocrinology and Infertility, Department Obstetrics, Gynecology and Women’s HealthAlbert Einstein College of MedicineBronxUSA
  2. 2.Reproductive Endocrinology and Infertility, Department Obstetrics, Gynecology and Reproductive SciencesYale University School of MedicineNew HavenUSA
  3. 3.Montefiore’s Institute for Reproductive Medicine and HealthHartsdaleUSA

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