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Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To explore whether the presence of a Y chromosome AZFc microdeletion confers any adverse effect on the outcomes of intracytoplasmic sperm injection (ICSI) with fresh ejaculated sperm.

Methods

A total of 143 oligozoospermia patients with Y chromosome AZFc microdeletion in ICSI cycles in a five-year period were studied. Infertile men with normal Y chromosome in ICSI at the same time-frame were used as controls matched to the study group for age of female, female’s body mass index, male’s age, infertility duration and number of oocytes retrieved. Retrospective case–control study was used.

Results

There were no significant differences between groups in clinical outcomes of endometrial thickness, transferred embryos, good embryo rates, implantation rates, biochemical pregnancy rates, clinical pregnancy rates, ectopic pregnancy rates, miscarriage rates, preterm birth rates, the ratio of male and female babies, newborn body height, newborn weight, low birth weight and birth defects (P > 0.05). Patients with Y chromosome AZFc microdeletion had a lower fertilization rate (61.8 % vs. 67.8 %, P < 0.05) and higher cleaved embryo rate (94.0 % vs. 88.1 %, P < 0.05).

Conclusions

ICSI clinical outcomes for oligozoospermic patients with Y chromosome AZFc microdeletion are basically comparable to that of infertile patients with normal Y chromosomes. The results of ICSI were not affected by the AZFc deletion. Preimplantation genetic diagnosis (PGD) before ICSI for Y chromosome AZFc microdeletion may not be a justifiable regular procedure if the couples didn’t care the vertical transmission of Y chromosome deletion.

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Authors and Affiliations

  1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China

    Xiao-hong Liu, Jie Qiao, Rong Li, Li-ying Yan & Li-xue Chen

  2. Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, 100191, China

    Xiao-hong Liu, Jie Qiao, Rong Li, Li-ying Yan & Li-xue Chen

  3. Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, 100191, China

    Xiao-hong Liu, Jie Qiao, Rong Li, Li-ying Yan & Li-xue Chen

  4. Beijing Haidian Maternal and Child Health Hospital, Beijing, 100080, China

    Xiao-hong Liu

Authors
  1. Xiao-hong Liu
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  2. Jie Qiao
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  3. Rong Li
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  4. Li-ying Yan
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  5. Li-xue Chen
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Corresponding author

Correspondence to Jie Qiao.

Additional information

Capsule The object of this study is to explore whether the presence of a Y chromosome AZFc microdeletion confers any adverse effect on the outcomes of intracytoplasmic sperm injection (ICSI). The results show that there is no difference in ICSI clinical outcomes between oligozoospermic patients with Y chromosome AZFc microdeletion and that with normal Y chromosomes.

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Liu, Xh., Qiao, J., Li, R. et al. Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm. J Assist Reprod Genet 30, 813–819 (2013). https://doi.org/10.1007/s10815-013-0009-y

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  • DOI: https://doi.org/10.1007/s10815-013-0009-y

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