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Maternal origin of 47,XXY and confined placental mosaicism 47,XXY/48,XXY,+13 in an infant conceived through IVF

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Acknowledgments

We gratefully thank the patients for donating their blood samples as well as the placenta. This study was supported by the Canadian Institutes of Health Research (MOP-77549 to SM).

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada, V6H 3N1

    Elizabeth X. Wu, Andrew D. Wilson, Edgar Chan Wong, Jon C. Havelock & Sai Ma

  2. BC Women’s Hospital and Health Centre, Room D414B, 4500 Oak Street, Vancouver, British Columbia, Canada, V6H 3N1

    Sai Ma

Authors
  1. Elizabeth X. Wu
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  2. Andrew D. Wilson
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  3. Edgar Chan Wong
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  4. Jon C. Havelock
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  5. Sai Ma
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Corresponding author

Correspondence to Sai Ma.

Additional information

Elizabeth Wu and Andrew Wilson contributed equally to this work.

Capsule

The additional X chromosome and chromosome 13 in an IVF conceived infant with Klinefelter syndrome and CPM trisomy 13 were found to be of maternal origin. Multiple segregation errors in a single pregnancy suggest a genetic predisp osition to nondisjunction events.

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Wu, E.X., Wilson, A.D., Wong, E.C. et al. Maternal origin of 47,XXY and confined placental mosaicism 47,XXY/48,XXY,+13 in an infant conceived through IVF. J Assist Reprod Genet 30, 807–812 (2013). https://doi.org/10.1007/s10815-013-0001-6

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  • DOI: https://doi.org/10.1007/s10815-013-0001-6

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