Journal of Assisted Reproduction and Genetics

, Volume 30, Issue 1, pp 35–41 | Cite as

Relationship between psychological stress and reproductive outcome in women undergoing in vitro fertilization treatment: Psychological and neurohormonal assessment

  • Yuan An
  • Zhuangzhuang Sun
  • Linan Li
  • Yajuan Zhang
  • Hongping JiEmail author



To evaluate whether psychological stress, as well as changes in hypothalamus-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) at different time points during a first in vitro fertilization (IVF) cycle, correlates with the reproductive outcome.


A prospective study was conducted in 264 women undergoing IVF or intracytoplasmic sperm injection (ICSI) treatment between January 2009 and March 2010. Standardized psychological questionnaires were used to assess anxiety and depression. Norepinephrine and cortisol in serum were measured with specific assays.


The non-pregnant women reported higher anxiety and depression scores at the pregnancy detection day compared with the pregnant group. Lower levels of norepinephrine and cortisol at the time of oocyte retrieval and lower levels of cortisol at the time of pregnancy test were found in women with successful treatment. Significant increases in serum norepinephrine and cortisol values were observed during ovarian stimulation. State Anxiety scores were negatively correlated with live birth rate, and positively associated with serum norepinephrine and cortisol values.


State anxiety is associated with both pregnancy rate and live birth rate in IVF patients, an effect that is partly mediated by activities in the HPA and SNS.


Cortisol In vitro fertilization Live birth rate Norepinephrine Pregnancy rate Stress 



The authors would like to thank all of the women who participated in the study. This study was supported by the “Doctor fund” of the First Affiliated Hospital of Harbin Medical University(grant no. 2011BS019), as well as the scientific project of Health Bureau in Heilongjiang Province(grant no. 2012–538).


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Yuan An
    • 1
  • Zhuangzhuang Sun
    • 1
  • Linan Li
    • 1
  • Yajuan Zhang
    • 1
  • Hongping Ji
    • 1
    Email author
  1. 1.Department of Reproductive MedicineThe First Affiliated Hospital of Harbin Medical UniversityHarbinChina

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