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Frequent polymorphisms of FSH receptor do not influence antral follicle responsiveness to follicle-stimulating hormone administration as assessed by the Follicular Output RaTe (FORT)

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To verify whether carriers of common single-nucleotide polymorphisms (SNPs) of the FSH receptor (FSHR) show reduced responsiveness of antral follicles to FSH administration as assessed by the FORT.

Methods

We performed a prospective study in a university hospital. Study population consisted of 124 Caucasian IVF-ET candidates. FSHR 307Ala and 680Ser variants were analyzed in haplotypes and as separated genes. Serum FSH, estradiol (E2), and anti-Müllerian hormone (AMH) were measured on cycle-day 3. Antral follicle (3–8 mm) count (AFC) and preovulatory follicle (16–22 mm) count (PFC) were performed, respectively, at the achievement of pituitary suppression (before FSH administration) and on the day of hCG administration. Antral follicle responsiveness to FSH administration assessed by the FORT (PFCx100/AFC).

Results

Data concerning baseline and IVF-ET parameters were similar between SNPs carriers and controls. Moreover, FORT was similar for different haplotypes Thr307-Asn680 (45.9%) and Ala307-Ser680 (39.4%) and 307Thr/Ala-Ala/Ala (41.1%; 5.0–91.6%) versus 307Thr/Thr (44.4%; 17.3–83.3%) and in 680Asn/Ser-Ser/Ser (40.0%; 5.0–91.6%) versus 680Asn/Asn (42.2%; 8.3–90.0%) carriers.

Conclusions

Antral follicle responsiveness to FSH, as far as measured by the FORT, is not influenced by the presence of SNPs of FSHR 307Ala and 680Ser.

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Financial support

This study was supported by a scholarship from the CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) and a grant from the Fundo de Incentivo a Pesquisa (FIPE) of Hospital de Clínicas de Porto Alegre—RS—Brazil.

Author information

Authors and Affiliations

  1. Postgraduate Program in Medical Clinics of the Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Vanessa Krebs Genro & João Sabino Cunha-Filho

  2. Terapia Genica Research Unit, Research Center of Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil

    Ursula Matte

  3. Department of Obstetrics and Gynecology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Emily De Conto & João Sabino Cunha-Filho

  4. AP-HP, Centre de Médecine et Biologie de la Reproduction, Hôpital Antoine Béclère, Clamart, 92141, France

    Renato Fanchin

  5. Univ Paris-Sud, Clamart, 92140, France

    Renato Fanchin

  6. INSERM, U782, Clamart, 92140, France

    Renato Fanchin

Authors
  1. Vanessa Krebs Genro
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  2. Ursula Matte
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  3. Emily De Conto
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  4. João Sabino Cunha-Filho
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  5. Renato Fanchin
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Corresponding author

Correspondence to Vanessa Krebs Genro.

Additional information

Capsule

FSH receptor genotype does not influence antral follicle responsiveness to exogenous gonadotropin as far as measured by FORT.

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Genro, V.K., Matte, U., De Conto, E. et al. Frequent polymorphisms of FSH receptor do not influence antral follicle responsiveness to follicle-stimulating hormone administration as assessed by the Follicular Output RaTe (FORT). J Assist Reprod Genet 29, 657–663 (2012). https://doi.org/10.1007/s10815-012-9761-7

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  • DOI: https://doi.org/10.1007/s10815-012-9761-7

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