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Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men

  • Genetics
  • Published:
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Abstract

Purpose

To investigate the association between SEPTIN12 gene variants and the risk of azoospermia caused by meiotic arrest.

Methods

Mutational analysis of the SEPTIN12 gene was performed using DNA from 30 Japanese patients with azoospermia by meiotic arrest and 140 fertile male controls.

Results

The frequencies of the c.204G>C (Gln38His) allele and the CC genotype were significantly higher in patients than in fertile controls (p < 0.05).

Conclusion

The c.204G>C (Gln38His) variant in the SEPTIN12 gene was associated with increased susceptibility to azoospermia caused by meiotic arrest.

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Acknowledgments

This study was supported by Grants-in-Aid for Scientific Research (22591811, 22591812, and 23592388) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and the Ministry of Health, Labour and Welfare of Japan.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Asahikawa Medical University, Midorigaokahigashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan

    Toshinobu Miyamoto, Michiharu Horikawa & Kazuo Sengoku

  2. Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan

    Akira Tsujimura & Yasushi Miyagawa

  3. Department of Integrated Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan

    Eitetsu Koh & Mikio Namiki

  4. Division of Community Medicine and Epidemiology, Department of Health Science, Asahikawa Medical University, Asahikawa, Japan

    Yasuaki Saijo

Authors
  1. Toshinobu Miyamoto
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  2. Akira Tsujimura
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  3. Yasushi Miyagawa
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  4. Eitetsu Koh
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  5. Mikio Namiki
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  6. Michiharu Horikawa
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  7. Yasuaki Saijo
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  8. Kazuo Sengoku
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Corresponding author

Correspondence to Toshinobu Miyamoto.

Additional information

Grants

Grants-in-Aid for Scientific Research (22591811, 22591812, and 23592388) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, the Ministry of Health, Labour and Welfare of Japan.

Capsule c.204G>C (Gln38His) variant in the SEPTIN12 gene was associated with increased susceptibility to azoospermia by meiotic arrest in Japanese men.

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Miyamoto, T., Tsujimura, A., Miyagawa, Y. et al. Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men. J Assist Reprod Genet 29, 47–51 (2012). https://doi.org/10.1007/s10815-011-9679-5

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  • DOI: https://doi.org/10.1007/s10815-011-9679-5

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