Abstract
Purpose
To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest.
Methods
Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls.
Results
The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (p < 0.001).
Conclusion
The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.
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Acknowledgments
This study was supported by Grants-in-Aid for Scientific Research (Nos 22591811, 22591812 and 20591902) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, to the Ministry of Health, Labour and Welfare of Japan.
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Grants: Grants-in-Aid for Scientific Research (Nos 22591811, 22591812 and 20591902) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, the Ministry of Health, Labour and Welfare of Japan.
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c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia in Japanese men.
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Miyamoto, T., Tsujimura, A., Miyagawa, Y. et al. Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest. J Assist Reprod Genet 28, 743–746 (2011). https://doi.org/10.1007/s10815-011-9576-y
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DOI: https://doi.org/10.1007/s10815-011-9576-y