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Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome

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Abstract

Purpose

The purpose of this study was to evaluate the associations between polymorphisms in vitamin D receptor (VDR), parathyroid hormone (PTH), calcium sensing receptor (CASR), insulin receptor (INSR), and adiponectin (ADIPOQ) genes and biochemical characteristics of women with polycystic ovary syndrome (PCOS).

Methods

Serum levels of LH, FSH, estradiol, testosterone, prolactin, SHBG, glucose, IGF-1, IGFBP-1, calcium, phosphorus, PTH, 25(OH)D, and 1,25(OH)2 D were measured in 56 women with PCOS. Furthermore, genotyping five, one, one, two, and two polymorphisms of the VDR, PTH, CASR, INSR, and ADIPOQ genes, respectively, were performed.

Results

The VDR TaqI “CC” genotype was associated with elevated serum levels of LH (p = 0.011). There were significant associations between decreased levels of SHBG and both VDR BsmI “GG” (p = 0.009) and ADIPOQ BsmI “CC” (p = 0.016) genotypes. Furthermore, patients with CaSR Hin1I “TG” genotype showed higher HoMA-IR (p = 0.008). All these associations remained significant after Bonferroni correction. In addition, phosphorus correlated negatively with estradiol (r = −0.298, P = 0.026) and positively with glucose (r = 0.287, P = 0.032).

Conclusions

These data indicated for the first time that it is possible that the VDR and CASR gene variants through their effects on LH and SHBG levels, and insulin resistance are involved in pathogenesis of PCOS.

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Acknowledgments

The authors thank all the subjects for participating. This work was supported by a grant from the Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences.

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Correspondence to Touraj Mahmoudi.

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Capsule

It is possible that VDR and CASR gene variants, at least in part, through their effects on LH and SHBG levels, and insulin resistance are involved in pathogenesis of PCOS.

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Ranjzad, F., Mahban, A., Irani Shemirani, A. et al. Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome. J Assist Reprod Genet 28, 225–232 (2011). https://doi.org/10.1007/s10815-010-9506-4

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  • DOI: https://doi.org/10.1007/s10815-010-9506-4

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