Skip to main content

Advertisement

SpringerLink
Log in

In vitro fertilisation (IVF) with donor eggs in post-menopausal women: are there differences in pregnancy outcomes in women with premature ovarian failure (POF) compared with women with physiological age-related menopause?

  • Assisted Reproduction
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

This study assessed pregnancy rates and obstetric outcomes in women with premature ovarian failure (Group A) with post-menopausal women ≥40 years (Group B) who had IVF ± ICSI using donor eggs.

Methods

This was a retrospective analysis of 54 recipients with either premature ovarian failure or physiological menopause undergoing oocyte donation between 2000 and 2007 at Monash IVF.

Results

The average number of stimulated cycles required for a woman in group A and B to deliver a baby was 1.75 and 1.4 respectively. Both groups had high cumulative pregnancy rates; however, there was a statistically significant difference with regards to rates of complications.

Conclusion

Oocyte donation in both premature ovarian failure and physiological menopause is highly successful and cumulative pregnancy rate is an important statistic which can be used to inform women seeking this technique. High rates of complications, in conjunction with individual risk-factor analysis needs to be considered when counselling post-menopausal women about oocyte donation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Budak E, Garrido N, Soares S, Melo M, Meseguer M, Pellicer A, et al. Improvements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and pregnancy rates and decrease in high-order multiple pregnancies. Fertil Steril. 2007;88:342–9.

    Article  PubMed  Google Scholar 

  2. Sauer M, Kavic S. Oocyte and embryo donation in 2006: reviewing two decades of innovation and controversy. Reprod Biomed Online. 2006;12:153–62.

    PubMed  Google Scholar 

  3. National Perinatal Statistics Unit (NPSU), Australian Institue of Health and Welfare. Assisted Reproductive Technolgy in Australia and New Zealand; 2005.

  4. Coulam C. Premature gonadal failure. Fertil Steril. 1982;38:645–55.

    CAS  PubMed  Google Scholar 

  5. Chatterjee S, Modi D, Maitra A, et al. Screening for FOXL2 gene mutations in women with premature ovarian failure: an Indian experience. Reprod Biomed Online. 2007;15(5):554–60.

    Article  CAS  PubMed  Google Scholar 

  6. Van Kasteren Y, Shoemaker J. Premature ovarian failure: a systematic review on therapeutic interventions to restore ovarian function and achieve pregnancy. Hum Reprod Updat. 1999;5:483–92.

    Article  Google Scholar 

  7. Paulson R, Hatch I, Lobo R, Sauer M. Cumulative conception and live birth rates after oocyte donation: implications regarding endometrial receptivity. Human Reprod. 1997;12:835–9.

    Article  CAS  Google Scholar 

  8. Mirkin S, Gimeno T, Bovea C, Stadtmauer L, Gibbons W, Oehninger S. Factors associated with an optimal pregnancy outcome in an oocyte donation program. J Assist Reprod Genet. 2003;20:400–8.

    Article  PubMed  Google Scholar 

  9. Infertility Treatment Authority, Australia. Accessed at http://www.ita.org.au on 21/05/08.

  10. Simchen M, Yinon Y, Schiff E, Sivan E. Pregnancy outcome after age 50. Obstet Gynecol. 2006;108:1084–8.

    PubMed  Google Scholar 

  11. Kreig S, Henne M, Westphal L. Obstetric outocmes in donor oocyte pregnancies compared with advanced maternal age in vitro fertilisation pregnancies. Fert and Steril. 2008;90:65–70.

    Article  Google Scholar 

  12. Toner J, Grainer D, Frazier L. Clinical outcomes among recipients of donated eggs: an analysis of the U.S national experience, 1996-1998. Fert and Steril. 2002;78:1038–45.

    Article  Google Scholar 

  13. Gunby J, Bissonnetter F, Librach C, Cowan L. Assisted reproductive technologies (ART) in Canada: 2004 results from the Canadian ART Register. Fertil and Steril. 2008;89:1123–32.

    Article  Google Scholar 

  14. Paulson R, Boostanfar R, Saadat P, et al. Pregnancy in the sixth decade of life: obstetric outcomes in women of advanced reproductive age. JAMA. 2002;288(18):2320–3.

    Article  PubMed  Google Scholar 

  15. Keegan D, Krey L, Chang H, Noyes N. Increased risk of pregnancy-induced hypertension in young recipients of donated oocytes. Fert and Steril. 2007;87:776–80.

    Article  Google Scholar 

  16. Pados G, Camus M, Van Steirteghem A, et al. The evolution and outcome of pregnancies from oocyte donation. Hum Reprod. 1994;9:538–42.

    CAS  PubMed  Google Scholar 

  17. Legro R, Wong I, Paulson R, Lobo R, Sauer M. Recipient’s age does not adversely affect pregnancy outcome after oocyte donation. Am J Obstet Gynecol. 1995;172:96–100.

    Article  CAS  PubMed  Google Scholar 

  18. Sauer M, Paulson R, Lobo R. Pregnancy in women 50 or more years of age: outcomes of 22 consecutively established pregnancies form oocyte donation. Fertil Steril. 1995;64:111–5.

    CAS  PubMed  Google Scholar 

  19. Sauer M, Paulson R, Lobo R. Oocyte donation to women of advanced reproductive age: pregnancy results and obstetrical outcomes in patients 45 years and older. Human Reprod. 1996;11:2540–3.

    CAS  Google Scholar 

Download references

Author information

Author notes

  1. Devini Ameratunga

    Present address: , 404/5 Greeves St, St Kilda, Melbourne, Victoria, 3182, Australia

Authors and Affiliations

  1. Monash Medical Centre, Clayton, Victoria, Australia

    Devini Ameratunga

  2. Monash IVF, Monash University, Clayton, Victoria, Australia

    Gareth Weston, Tiki Osianlis & James Catt

  3. Centre for Women’s Health Research, Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia

    Beverley Vollenhoven

Authors
  1. Devini Ameratunga
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gareth Weston
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tiki Osianlis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. James Catt
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Beverley Vollenhoven
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Devini Ameratunga.

Additional information

Capsule

Oocyte donation in POF and physiological menopause is highly successful. However, there are significant differences in rates of complications between these two groups.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ameratunga, D., Weston, G., Osianlis, T. et al. In vitro fertilisation (IVF) with donor eggs in post-menopausal women: are there differences in pregnancy outcomes in women with premature ovarian failure (POF) compared with women with physiological age-related menopause?. J Assist Reprod Genet 26, 511–514 (2009). https://doi.org/10.1007/s10815-009-9351-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10815-009-9351-5

Keywords

Search

Navigation