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Influence of smoking on outcome of COH and IUI in subfertile couples

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Abstract

Aim

To evaluate the influence of smoking on the outcome of COH and IUI in subfertile couples.

Patients and methods

We reviewed the medical files of all consecutive women, age ≤35 years, attending our infertility clinics over an eigth-year period. Data on patient age, smoking habits, and variable related to infertility-treatment were collected from the files.

Results

A total of 2,318 cases were evaluated: 1,803 in nonsmoking patients (n = 679) and 515 in smokers (n = 206). The smokers used significantly more gonadotropin ampoules and gained a thinner endometrium on the day of hCG administration than the nonsmokers (p < 0.016 for both). There were no between-groups differences in patient age, duration of gonadotropin stimulation, number of follicle >14 mm in diameter, or E2 levels on the day of hCG administration.

Conclusion

Smokers undergoing COH with IUI required a significantly higher gonadotropin dosage than nonsmokers in order to achieved a comparable pregnancy rate.

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Authors and Affiliations

  1. Fertility Clinics, Ashdod and Holon Women’s Health Centers, Clalit Medical Services, Tel Aviv, Israel

    Jacob Farhi

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Jacob Farhi

  3. Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel

    Raoul Orvieto

  4. Ben Gurion University School of Medicine, Beer Sheva, Israel

    Raoul Orvieto

  5. Infertility and IVF Unit, Department of Obstetrics & Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, 49100, Israel

    Jacob Farhi

Authors
  1. Jacob Farhi
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  2. Raoul Orvieto
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Corresponding author

Correspondence to Jacob Farhi.

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Capsule

Smokers undergoing COH with IUI required a significantly higher gonadotropin dosage than nonsmokers in order to achieved a comparable pregnancy rate.

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Farhi, J., Orvieto, R. Influence of smoking on outcome of COH and IUI in subfertile couples. J Assist Reprod Genet 26, 421–424 (2009). https://doi.org/10.1007/s10815-009-9330-x

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  • DOI: https://doi.org/10.1007/s10815-009-9330-x

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