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Route of progesterone administration for luteal phase support may affect outcome of controlled ovarian hyperstimulation for IVF with ICSI using GnRH antagonist

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Abstract

Purpose

This study evaluated the impact of route of progesterone administration as luteal phase support on the outcome of assisted conception cycles.

Methods

Intramuscular progesterone in oil (IMP) at 100 mg daily was administered to 903 women following oocyte retrieval whereas vaginal progesterone gel (VMP) at 90 mg was administered twice daily to 1,110 women. Retrospective analysis was performed according to the type of GnRH analogue used. Implantation (IR), clinical pregnancy (CPR) and biochemical pregnancy rates (BPR) were main outcomes.

Results

In GnRH agonist cycles, neither IR, CPR or BPR differed according to the route of progesterone. However, in GnRH antagonist cycles, IR and CPR were significantly lower in VMP group compared to IMP group. BPR also was significantly higher in VMP group compared to IMP group.

Conclusion

Our results suggest that route of progesterone administration for luteal phase support can be an important prognostic factor according to the type of GnRH analogue used for controlled ovarian hyperstimulation.

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Authors and Affiliations

  1. Bahceci Women Health Care Center, Azer Is Merkezi 44-17, Nisantasi, Abdi Ipekci Cad., 80200, Istanbul, Turkey

    Mustafa Bahceci & Ulun Ulug

  2. Bahceci Women Health Care Center and German Hospital in Istanbul, Istanbul, Turkey

    Mustafa Bahceci

Authors
  1. Mustafa Bahceci
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  2. Ulun Ulug
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Correspondence to Mustafa Bahceci.

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Bahceci, M., Ulug, U. Route of progesterone administration for luteal phase support may affect outcome of controlled ovarian hyperstimulation for IVF with ICSI using GnRH antagonist. J Assist Reprod Genet 25, 499–502 (2008). https://doi.org/10.1007/s10815-008-9269-3

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  • DOI: https://doi.org/10.1007/s10815-008-9269-3

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