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Hyaluronan in follicular fluid and embryo implantation following in vitro fertilization and embryo transfer

  • ASSISTED REPRODUCTION
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Abstract

Purpose

To determine whether the concentration of hyaluronan (HA) in follicular fluid predicts implantation success following embryo transfer.

Methods

Follicular fluids from 170 IVF patients were tested by ELISA for HA concentration.

Results

The mean (standard error) HA concentration in follicular fluids was 158.0 (21.9) ng/ml from women whose embryos did not implant, 220.0 (21.3) ng/ml from women in which one embryo implanted and 239.3 (40.1) ng/ml from women with 2–3 implantations (implantation vs. no implantation p = .019). The HA level was unrelated to maternal age, number of oocytes harvested or fertilized or number of embryos transferred. Follicular fluids from women with an endocrine problem had a lower mean HA level (142.0 ng/ml) as compared to women undergoing IVF due to male factor infertility (257.3 ng/ml) (P = .05).

Conclusions

HA in follicular fluid is decreased in women with unsuccessful implantation or with an endocrine disorder. A woman’s level of HA production may influence the potential for implantation of her embryos.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, Box 35, New York, NY, 10065, USA

    Arthur Babayan, Ann Marie Bongiovanni & Steven S. Witkin

  2. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Witten/Herdecke, Dortmund, Germany

    Andreas Neuer & Stefan Dieterle

Authors
  1. Arthur Babayan
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  2. Andreas Neuer
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  3. Stefan Dieterle
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  4. Ann Marie Bongiovanni
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  5. Steven S. Witkin
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Corresponding author

Correspondence to Steven S. Witkin.

Additional information

Capsule

Women with successful implantation following embryo transfer have higher levels of hyaluronan in their follicular fluid than women whose embryos do not implant.

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Babayan, A., Neuer, A., Dieterle, S. et al. Hyaluronan in follicular fluid and embryo implantation following in vitro fertilization and embryo transfer. J Assist Reprod Genet 25, 473–476 (2008). https://doi.org/10.1007/s10815-008-9268-4

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  • DOI: https://doi.org/10.1007/s10815-008-9268-4

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