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The association between polypronucleate zygote formation with certain motion characteristics of sperm and IVF outcome

  • Assisted Reproduction
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Abstract

Purpose

To determine the efficiency of sperm motion characteristics as predictors for normal (2PN) and polypronulceate (PPN) zygotes in IVF.

Methods

A retrospective cohort analysis for a total of 230 couples undergoing IVF treatment in a single infertility center.

Result(s)

Subsequent to semen analysis and hemizona assay, unexpected fertilization failure would appear to have occurred only extremely rarely (1/236, 0.4%). The rate of PPN, however, did arise and appeared to be related to certain sperm motion characteristics, such as lateral head displacement and concentration of progressive motile sperm. Interestingly, the patients featuring a high PPN rate (>20%) was associated with a greater pregnancy rate than those featuring a low PPN rate (<20%).

Conclusion

The sperm motion characteristics examined herein could be utilized to predict the rate of PPN in IVF. In order to enhance the rate of 2PN and maintain the relative high rate of clinical pregnancy, an efficient method needs further investigation and development.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan

    Tsung-Hsien Lee & Shee-Uan Chen

  2. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan

    Tsung-Hsien Lee, Chung-Hsien Liu & Maw-Sheng Lee

  3. The Infertility Clinic Division, Lee Women‘s Hospital, No. 263, Pei-Tun Road, Taichung 406, Taiwan, Republic of China

    Chun-Chia Huang, Hsui-Hui Chen & Maw-Sheng Lee

  4. Department of Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan

    Chun-Chia Huang

  5. Department of Medicine, China Medical University, Taichung, Taiwan

    Maw-Sheng Lee

Authors
  1. Tsung-Hsien Lee
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  2. Chung-Hsien Liu
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  3. Chun-Chia Huang
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  4. Hsui-Hui Chen
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  5. Shee-Uan Chen
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  6. Maw-Sheng Lee
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Corresponding author

Correspondence to Maw-Sheng Lee.

Additional information

Financial support This study was supported by the Chinese Infertility Foundation.

Capsule The combination of CASA and hemi-zona assay is adequate for directing IVF or ICSI treatment; further, sperm motion characteristics correlate with the polypronucleate zygote formation.

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Lee, TH., Liu, CH., Huang, CC. et al. The association between polypronucleate zygote formation with certain motion characteristics of sperm and IVF outcome. J Assist Reprod Genet 25, 35–41 (2008). https://doi.org/10.1007/s10815-007-9190-1

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  • DOI: https://doi.org/10.1007/s10815-007-9190-1

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