Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function
We assessed the role of DHEA supplementation on pregnancy rates in women with diminished ovarian function.
This is a case control study of 190 women with diminished ovarian function. The study group includes 89 patients who used supplementation with 75 mg daily of oral, micronized DHEA for up to 4 months prior to entry into in vitro fertilization (IVF). The control group is composed of 101 couples who received infertility treatment, but did not use DHEA. The primary outcome was clinical pregnancy after the patient’s initial visit. We developed a Cox proportional hazards model to compare the proportional hazards of pregnancy among women using DHEA with the controls group.
Cumulative clinical pregnancy rates were significantly higher in the study group (25 pregnancies; 28.4% vs. 11 pregnancies; 11.9%; relative hazard of pregnancy in study group (HR 3.8; 95% CI 1.2–11.8; p < 0.05).
DHEA treatment resulted in significantly higher cumulative pregnancy rates. These data support a beneficial effect of DHEA supplementation among women with diminished ovarian function.
KeywordsDehydroepiandrosterone Diminished ovarian reserve Infertility In vitro fertilization, Pregnancy rates Age Life table analysis
- 5.Barad D, Weghofer A, Gleicher N. O-291: evidence for an empiric definition of diminished ovarian reserve (DOR), ovarian resistance to stimulation and diagnosis of premature ovarian aging (POA), based on age-specific baseline FSH levels. Fertil Steril 2006;86(3, Supplement 1):S125–S6.CrossRefGoogle Scholar
- 16.Gore-Langton R, Armstrong D. Follicular steroidogenesis and its control. In: Knobil E, Neill J, editors. The physiology of reproduction. New York: Raven Press; 1988. p. p. 331–85.Google Scholar