Abstract
A 29 year old woman with difficult to control acromegaly and a pituitary macroadenoma responded to pegvisomant therapy and subsequently conceived with her first cycle of in-vitro fertilization and intra-cytoplasmic sperm injection. Pregnancy was complicated by gestational diabetes, pituitary gland enlargement and deteriorating visual fields. Conservative management with elective cesarean section was performed at 32 weeks gestation. A healthy boy was delivered who remains developmentally normal at 1 year. This complex case required intricate care by a multi-disciplinary team and is likely to represent the first in many cases of assisted conception on pegvisomant therapy for active acromegaly.
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We thank Dr Isaac Manyonda for helpful discussion and advice in the preparation of this report.
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This case report describes a successful pregnancy, managed by a functional multi-disciplinary team, following assisted conception in a subject with active acromegaly treated with pegvisomant.
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Qureshi, A., Kalu, E., Ramanathan, G. et al. IVF/ICSI in a woman with active acromegaly: Successful outcome following treatment with pegvisomant. J Assist Reprod Genet 23, 439–442 (2006). https://doi.org/10.1007/s10815-006-9077-6
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DOI: https://doi.org/10.1007/s10815-006-9077-6