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Determination of Vildagliptin Using a Simple and Sensitive Fluorescent Probe

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Journal of Applied Spectroscopy Aims and scope

Vildagliptin (VLG), a drug for the treatment of type 2 diabetes, is nonfluorescent in aqueous solution. This property makes it difficult to determine by direct fluorometric methods. We proposed a new competitive method for fluorometric detection of VLG using CB[7]–BER (cucurbit[7]uril = CB[7], BER = berberine) as a fluorescent probe. The method showed a good calibration curve within the concentration range 0.00213–1.820 μg/mL with an excellent correlation coefficient (r2 > 0.999). The detection limit is 0.64 ng/mL for CB[7]–BER fluorescent probe. Moreover, the method was successfully applied for the determination of VLG in pharmaceutical tablets and artificial urine. To our knowledge, this is the first example of determining VLG using a fluorescent probe method.

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Authors and Affiliations

  1. College of Chemistry, Baicheng Normal University, Baicheng, Jilin, China

    Jia Jia

  2. School of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of Technology, Changchun, China

    Mei Liu

  3. Institute of Chemical and Industrial Bioengineering, Jilin Engineering Normal University, Changchun, China

    Lihui Liu

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  1. Jia Jia
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  2. Mei Liu
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Correspondence to Mei Liu.

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Abstract of article is published in Zhurnal Prikladnoi Spektroskopii, Vol. 90, No. 4, p. 657, July–August, 2023.

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Jia, J., Liu, M. & Liu, L. Determination of Vildagliptin Using a Simple and Sensitive Fluorescent Probe. J Appl Spectrosc 90, 893–899 (2023). https://doi.org/10.1007/s10812-023-01611-w

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