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Study of Phenylalanine NIR Spectra for Phenylketonuria Determination

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Journal of Applied Spectroscopy Aims and scope

The aim of this study is to investigate the spectroscopic characteristics of phenylalanine in the NIR spectral range as a preliminary step towards the development of an in vivo method for the determination of phenylalanine in the blood of newborn babies. The first steps in this study included in vitro experiments with mixtures of phenylalanine, saline, and whole blood. Results showed absorption bands in the NIR spectral range that are assigned to overtones of C–H, N–H, and O–H in the range of 1400 to 1700 nm, which together with the melanin absorption lines in the visible spectra range, demonstrate the potential of NIR/VIS spectroscopy as an inexpensive, noninvasive, rapid, and accurate alternative to routine methods for determining of phenylketonuria.

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Authors and Affiliations

  1. Ruppin Academic Center, Engineering School at Medical Engineering Department, EmekHefer, Israel

    B. Z. Dekel

  2. School of Electronic Engineering Institute of Electronics and Mathematics (MIEM HSE) at National Research University Higher School of Economics, Moscow, 101000, Russia

    Y. Cohen

  3. Hillel Yaffe Medical Center at Newborn and Neonatal Care Department, Hadera, Israel

    M. Feldman

Authors
  1. B. Z. Dekel
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  2. Y. Cohen
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  3. M. Feldman
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Corresponding author

Correspondence to B. Z. Dekel.

Additional information

Abstract of article is published in Zhurnal Prikladnoi Spektroskopii, Vol. 87, No. 6, p. 1022, November–December, 2020.

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Dekel, B.Z., Cohen, Y. & Feldman, M. Study of Phenylalanine NIR Spectra for Phenylketonuria Determination. J Appl Spectrosc 87, 1179–1184 (2021). https://doi.org/10.1007/s10812-021-01127-1

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  • DOI: https://doi.org/10.1007/s10812-021-01127-1

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