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Development and Validation of the Spectrophotometric Method for the Determination of Menthol

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Journal of Applied Spectroscopy Aims and scope

The main objective of the present study is a quantitative determination of menthol using a simple, sensitive, and reproducible method of reacting menthol with an aromatic aldehyde (salicylaldehyde) in an acidic medium. A linear response was observed between the concentration and the absorbance in the range 0.02–3 mg/5 mL possessing a correlation coefficient greater than 0.999 and exhibiting good recovery values (99.54–100.40%). The wavelength of the maximum absorbance (λmax) was measured at 498 nm immediately after the reaction and subsequently within 1 h. The proposed method was validated according to the ICH guidelines for parameters including linearity, precision, accuracy, range, stability, and robustness. Hence the developed method can be used in the analysis of menthol in drug formulations.

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Authors and Affiliations

  1. Institute of Nuclear Medicine & Allied Sciences, DRDO, Delhi, India

    H. Kushwah, G. Mittal & N. Sandal

  2. Indian Institute of Technology, Gandhinagar, Gujarat, India

    T. Hans

  3. Delhi Institute of Pharmaceutical Sciences and Research, Delhi, India

    M. Chauhan

Authors
  1. H. Kushwah
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  2. T. Hans
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  3. M. Chauhan
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  4. G. Mittal
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  5. N. Sandal
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Corresponding author

Correspondence to N. Sandal.

Additional information

Abstract of article is published in Zhurnal Prikladnoi Spektroskopii, Vol. 87, No. 3, p. 509, May–June, 2020.

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Kushwah, H., Hans, T., Chauhan, M. et al. Development and Validation of the Spectrophotometric Method for the Determination of Menthol. J Appl Spectrosc 87, 563–567 (2020). https://doi.org/10.1007/s10812-020-01039-6

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  • DOI: https://doi.org/10.1007/s10812-020-01039-6

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