Problems connected with the use of quantum-cascade lasers (QCLs) in biomedical practice are discussed. A comparative analysis was made of laser spectroscopic methods for noninvasive diagnostics of diseases by exhaled air; examples of the practical implementation of this idea based on QCL are given. The use of QCL in traditional laser surgery and laser angioplasty is discussed. Particular attention is paid to terahertz imaging of soft tissues, as well as to microspectroscopy and its use in the creation of hyperspectral images of biological tissue in the midinfrared range. A number of problems associated with the use of QCL in medicine are raised, and possible directions for promising research where QCL can play a decisive role are indicated.
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E. V. Stepanov, Tr. In-ta Obshchei Fiziki im. A. M. Prokhorova, 61, 47–53 (2005).
E. V. Stepanov and V. A. Milyaev, Kvantovaya Élektron., 32, No. 11, 987–992 (2002)
V. L. Vaks, E. G. Domracheva, E. A. Sobakinskaya, and M. B. Chernyaeva, Uspekhi Fiz. Nauk. 184, No. 7, 739–758 (2014).
V. Vaks, J. Infr. Millim. Terahertz Waves, 33, No. 1, 43–53 (2012).
L. A. Skvortsov, Zh. Prikl. Spektrosk., 81, No. 5, 653–678 (2014) [L. A. Skvortsov, J. Appl. Spectrosc., 81, 725–749 (2014)].
A. Schwaighofer, M. Brandstetter, and B. Lendl, Chem. Soc. Rev., 46, No. 19, 5903–5924 (2017).
K. Wörle, F. Seichter, A. Wilk, C. Armacost, T. Day, M. Godejohann, U. Wachter, and B. Mizaikoff, Analyt. Chem., 85, No. 5, 2697–2702 (2013).
C. Wang and P. Sahay, Sensors, 9, No. 10, 8230–8262 (2009).
V. Spagnolo, R. Lewicki, L. Dong, and F. K. Tittel, Proc. 2011 IEEE International Workshop on Medical Measurements and Applications (MeMeA), 332–335 (2011).
T. H. Risby and F. K. Tittel, Opt. Eng., 49, 111123–111137 (2010).
J. H. Shorter, D. D. Nelson, J. B. McManus, M. S. Zahniser, and D. K. Milton, IEEE Sens. J., 10, No. 1, 76–84 (2010).
K. Hashimura, K. Ishii, N. Akikusa, T. Edamura, H. Yoshida, and K. Awazu, J. Innovat. Opt. Health Sci., 7, No. 3, 1450029-1–9 (2014).
Y. Huang and J. Kang, Proc. SPIE, 8209, 82091W (2012)
K. Hashimura, K. Ishii, N. Akikusa, T. Edamura, H. Yoshida, and K. Awazu, Adv. Biomed. Eng., 1, 74–80 (2012).
K. Hashimura, K. Ishii, and K. Awazu, Opt. Rev., 23, No. 2, 299–306 (2016).
A. Schwaighofer, M. Montemurro, S. Freitag, C. Kristament, M. Culzoni, and B. Lendl, Analyt. Chem., 90, No. 11, 7072–7079 (2018).
S. Kim, F. Hatami, A. Gu, A. Kurian, J. Ford, J. Harris, G. Scalari, and J. Faist, in: Lasers and Electro-Optics Society, LEOS 2006, 19th Annual Meeting of the IEEE, 231–232 (2006).
S. Kim, F. Hatami, G. Harris, A. Kurian, J. Ford, D. King, G. Scalari, M. Giovanny, M. Hoyler, and J. Faist, Appl. Phys. Lett., 88, No. 15, 153903-1–153903-3 (2006).
C. Kuepper, A. Kallenbach-Thieltges, H. Juette, A. Tannapfel, F. Großerueschkamp, and K. Gerwert, Sci. Rep. (Nature Publisher Group), 8, No. 1, 1–10 (2018).
D. Zhang, C. Li, C. Zhang, M. Slipchenko, G. Eakins, and J. Cheng, Sci. Adv., 2, No. 9, e1600521-1–7 (2016).
M. Vitiello, G. Scalari, B. Williams, and P. Natale, Opt. Express, 23, No. 4, 5167–5182.
M. Razeghi, Q. Lu, N. Bandyopadhyay, W. Zhou, D. Heydari, Y. Bai, and S. Slivken, Opt. Express, 23, No. 7, 8462–8475 (2015).
R. Curl, F. Capasso, C. Gmachl, A. Kosterev, B. McManus, R. Lewicki, M. Pusharsky, G. Wysocki, and F. Tittel, Chem. Phys. Lett., 487, 1–18 (2010).
A. Lyakh, R. Maulini, A. Tsekoun, R. Go, C. Pflugl, L. Diehl, Q. Wang, F. Capasso, C. Kumar, and N. Patel, Appl. Phys. Lett., 95, No. 14, 14113-1–14113-9.
I. I. Zasabitskii, XII All-Russia Youth Concourse-Conference on Optics and Laser Physics, 12–16 November 2014, Samara (2014); http://www.myshared.ru/slide/968796.
J. Faist, D. Hofstetter, M. Beck, T. Aellen, M. Rochat, and S. Blaser, IEEE J. Quantum Electron., 38, No. 6, 533–546 (2002).
A. Tredicucci, F. Capasso, C. Gmachl, D. Sivco, A. Hutchinson, and A. Cho, Appl. Phys. Lett., 73, No. 15, 2101–2103 (1998).
J. Faist, M. Beck, T. Aellen, and E. Gini, Appl. Phys. Lett., 78, No. 2, 147–149 (2001).
M. Belkin and F. Capasso, Phys. Scripta, 90, No. 1, 118002-13 (2015).
B. Williams, S. Kumar, Q. Hu, and J. Reno, Electron. Lett., 42, No. 2, 89–91 (2006).
A. Lee, B. Williams, S. Kumar, Q. Hu, and J. Reno, Opt. Lett., 7, No. 35, 910–912 (2010)
B. Williams, Nature Photon., 1, No. 9, 517 (2007).
L. Skvortsov, Kvantovaya Élektron., 41, No. 12, 1051–1060 (2011).
L. Skvortsov, Laser Methods of Remote Detection of Chemical Compounds on the Surface of Bodies [in Russian], Tekhnosfera, Moscow (2014).
L. Skvortsov, Kvantovaya Élektron., 42, No. 1, 1–11 (2012).
H. Preier, Semicond. Sci. Technol., 5, S12–S20 (1990).
Yu. Kuritsyn, Infrared Spectroscopy with Injection Lasers. Analytical Laser Spectroscopy [in Russian] (Ed. V. S. Letokhov), Nauka, Moscow (1986), pp. 120–173.
L. Skvortsov, Principles of Photothermal Radiography and Laser Thermography [in Russian], Tekhnosfera, Moscow (2017).
D. Caffey, M. Radunsky, V. Cook, M. Weida, P. Buerki, S. Crivello, and T. Day, Proc. SPIE, 7953, 79531K (2011).
R. Mihalcea, D. Baer, and R. Hanson, Appl. Opt., 35, 4059–4064 (1996).
D. Baer, R. Hanson, M. Newfield, and N. Gopaul, Opt. Lett., 19, 1900–1902 (1994).
P. Eliseev, Introduction to Physics of Injection Lasers [in Russian], Nauka, Moscow (1983).
I. Gordon, L. Rothman, C. Hill, R. Kochanov, Y. Tan, P. Bernath, and B. Drouin, J. Quant. Spectrosc. Radiat. Transfer, 203, 3–69 (2017).
P. Kluczynski, J. Gustafsson, A. Lindberg, and O. Axner, Spectrochim. Acta B, 56, 1277–1354 (2001).
B. Brumfield, M. M. Taubman, and M. Phillips, Photonics, 3, No. 2, 33 (2016).
J. Haus, Optical Sensors: Basics and Applications, John Wiley & Sons (2010).
P. Zalicki and R. Zare, J. Chem. Phys., 102, No. 7, 2708–2717 (1995).
J. Wojtas, J. Mikolajczyk, and Z. Bielecki, Sensors, 13, No. 6, 7570–7598 (2013).
J. Scherer, J. Paul, H. Jiao, and A. O'Keefe, Appl. Opt., 40, 6725–6732 (2001).
D. Baer, J. Paul, J. Gupta, and A. O'Keefe, Appl. Phys. B: Lasers O., 75, 261–265 (2002).
Y. Bakhirkin, A. Kosterev, C. Roller, R. Curl, and F. Tittel, Appl. Opt., 43, 2257–2266 (2004).
Y. Bakhirkin, A. Kosterev, R. Curl, F. Tittel, D. Yarekha, L. Hvozdara, M. Giovannini, and J. Faist, Appl. Phys. B: Lasers O., 82, 149–154 (2006).
R. Peeters, G. Berden, A. Apituley, and G. Meijer, Appl. Phys. B: Lasers O., 71, 231–236 (2000).
H. Dahnke, D. Kleine, P. Hering, and M. Mürtz, Appl. Phys. B: Lasers O., 72, 971–975 (2001).
H. Dahnke, D. Kleine, C. Urban, P. Hering, and M. Mürtz, Appl. Phys. B: Lasers O., 72, 121–125 (2001).
G. von Basum, D. Halmer, P. Hering, M. Mürtz, S. Schiller, F. Mueller, A. Popp, and F. Kuehnemann, Opt. Lett., 29, 797–799 (2004).
D. Halmer, S. Thelen, P. Hering, and M. Mürtz, Appl. Phys. B: Lasers O., 85, 437–443 (2006).
D. Halmer, G. von Basum, P. Hering, and M. Mürtz, Opt. Lett., 30, 2314–2316 (2005).
P. Korolenko, I. Nikolaev, V. Ochkin, and S. Tskhai, Kvantovaya Élektron., 44, No. 4, 353–361 (2014).
A. O'Keefe, J. Scherer, and J. Paul, Chem. Phys. Lett., 307, Nos. 5–6, 343–349 (1999).
J. Paul, L. Lapson, and J. Anderson, Appl. Opt., 40, No. 27, 4904–4910 (2001).
G. Engel, W. Drisdell, F. Keutsch, E. Moyer, and J. Anderson, Appl. Opt., 45, No. 36, 9221–9229 (2006).
I. Nikolaev, V. Ochkin, M. Spiridonov, and S. Tskhai, Laser Phys., 21, 2088 (2011).
I. Nikolaev, V. Ochkin, and S. Tskhai, Laser Phys. Lett., 10, 115701 (2013).
L. Kreuzer, J. Appl. Phys., 42, 2934 (1971).
A. Rosencwaig and A. Gersho, J. Appl. Phys., 47, 64 (1976).
L. Skvortsov, Kvantovaya Élektron., 43, No. 1, 1–13 (2013).
L. Skvortsov, Recent Patent. Eng., 3, No. 2, 129–145 (2009).
B. Paldus, T. Spence, R. Zare, J. Oomens, F. Harren, D. Parker, and A. Hutchinson, Opt. Lett., 24, No. 3, 178–180 (1999).
F. Harren, G. Cotti, J. Oomens, and S. Hekkert, Encycloped. Analyt. Chem., 3, 2203–2226 (2000).
M. Haisch, P. Hering, P. Schadewaldt, H. Brosicke, B. Braden, S. Koletzko, and C. Steffen, Isotop. Environ. Health Stud., 30, Nos. 2–3, 253–257 (1994).
F. Harren and J. Reuss, Progress in Photothermal and Photoacoustic Science and Technology, Life and Earth Science in: A. Mandelis and P. Hess Eds., SPIE, Bellingham, WA, 3, 83–127 (1997).
A. Miklos, P. Hess, and Z. Bozoki, Rev. Sci. Instrum., 72, 1937–1955 (2001).
A. Elia, P. M. Lugarà, C. Di Franco, and V. Spagnolo, Sensors, 9, 9616 (2009).
A. Kosterev, Y. Bakhirkin, R. Curl, and F. Tittel, Opt. Lett., 27, No. 21, 1902–1904 (2002).
S. Ohira and K. Toda, Anal. Chim. Acta, 619, No. 2, 143–156 (2008).
P. Pellegrino and R. Polcawich, Chem. Biol. Sensing IV, 5085, 52–64 (2003).
M. Bain, N. Mitchell, B. Armstrong, J. Uotila, I. Kauppinen, E. Terray, and B. Ward, Miniaturization and Integration of a Cantilever Based Photoacoustic Sensor into Micro Micromachined Device, Abst., No. 45, 2579 (2011).
A. Slutsky, Am. J. Respir. Crit. Care Med., 160, 2104–2117 (1999).
Am. J. Respir. Crit. Care Med., 171, No. 8, 912–930 (2005).
P. Mazzone, X. Wang, Y. Xu, T. Mekhail, M. Beukemann, J. Na, and M. Sasidhar, J. Thoracic Oncol., 7, No. 1, 137–142 (2012).
J. Shorter, D. Nelson, J. McManus, M. Zahniser, and D. Milton, IEEE Sensors J., 10, No. 1, 76–84 (2010).
A. Reyes-Reyes, Z. Hou, E. van Mastrigt, R. Horsten, J. De Jongste, M. Pijnenburg, and N. Bhattacharya, Opt. Express, 22, No. 15, 18299–18309 (2014).
A. Reyes-Reyes, R. Horsten, H. Urbach, and N. Bhattacharya, Anal. Chem., 87, No. 1, 507–512 (2014).
Toshiba Develops Breath Analyzer for Medical Applications, Toshiba, Press Release (March 18, 2014).
Aerodyne Research Inc., Single Laser Quantum Cascade LaserTrace Gas Monitors: The Mini Monitor (2016).
Composition of Exhaled and Alveolar Air [in Russian], http://www.amedgrup.ru/vozduh.html.
M. Thorpe, K. Moll, J. Jones, B. Safdi, and J. Ye, Science, 311, 1595–1599 (2006).
M. Thorpe, D. Balslev-Clausen, M. Kirchner, and J. Ye, Opt. Express, 16, 2387–2397 (2008).
M. Bader, D. Tilki, G. Gratzke, R. Sroka, C. Stief, and O. Reich, World J. Urol., 28, 169–172 (2010).
N. Kelbauskiene, K. Baseviciene, A. Goharkhay, V. Moritz, and V. Machiulskeiene, Laser Med. Sci., 26, 445–452 (2011).
S. Renvert, C. Lindahl, A. Jansåker, and G. Persson, J. Clin. Periodontol., 38, 65–73 (2011).
A. Chapas, L. Brightman, S. Sukal, E. Hale, D. Daniel, L. Bernstein, and R. Geronemus, Lasers Surg. Med., 40, 381–386 (2008).
N. Kalintseva and V. Serebryakov, Fiber Methods for Delivery of Radiation for Medical Lasers of Mid-IR Region: Requirements and Parameters [in Russian]; book.sarov.ru/wp-content/uploads/lazer-X-2017-15.pdf.
B. Tarasevich, IR Spectra of Main Classes of Organic Compounds, Ref. Mater. [in Russian], MGU im. M. V. Lomonosova (2012).
Y. Andreev, A. Ionin, I. Kinyaevsky, Y. Klimachev, A. Kozlov, A. Kotkov, and A. Shaiduko, Quantum Electron., 43, No. 2, 139 (2013).
G. Edwards, R. Logan, M. Copeland, L. Reinisch, J. Davidson, B. Johnson, R. Maciunas, M. Mendenhall, R. Osso, J. Tribble, J. Werkhaven, and D. O'Day, Nature, 371, 416–419 (2004).
J. Youn, G. Peavy, and V. Venugopalan, Lasers Surg. Med., 36, 202–209 (2004).
M. Heya, Y. Fukami, H. Nagats, Y. Nishida, and K. Awazu, Nucl. Instrum. Meth. Phys. Res., A 507, 564–568 (2003).
M. Mackanos, J. Kozub, D. Hachey, K. Joos, D. Ellis, and E. Jansen, Phys. Med. Biol., 50, 1885–1899 (2005).
Y. Nakajima, K. Iwatsuki, K. Ishii, S. Suzuki, T. Fujinaka, T. Yoshimine, and K. Awazu, J. Neurosurg., 104, 426–428 (2006).
H. Hazama, Y. Takatani, and K. Awazu, Proc. SPIE, 6455, 645507 (2007).
M. Mackanos, D. Simanovskii, K. Joos, H. Schwettman, and E. Jansen, Lasers Surg. Med., 39, 230–236 (2007).
J. Kozub, B. Ivanov, A. Jayasinghe, R. Prasad, J. Shen, M. Klosner, D. Heller, M. Mendenhall, D. Piston, K. Joos, and M. Hutson, Biomed. Opt. Express, 2, 1275–1281 (2011).
G. Edwards, R. Pearlstein, M. Copeland, M. Hutson, K. Latone, A. Spiro, and G. Pasmanik, Opt. Lett., 32, 1426–1428 (2007).
H. Rong, S. Xu, O. Cohen, O. Raday, M. Lee, V. Sih, and M. Paniccia, Nature Photon., 2, No. 3, 170 (2008).
F. Koenz, M. Frenz, H. Prastisto, H. Weber, A. Silenok, and V. Konov, Proc. SPIE, 2624, 67 (1996).
A. Oraevsky, S. Jacques, R. Esenaliev, and F. Tittel, Lasers Surg. Med., 18, No. 3, 231 (1996).
G. Zheltov, O. Romanov, V. Burko, and É. Sobol, Laser Med., 20, No. 3, 96 (2016).
G. Zheltov, V. Lisinetskii, A. Grabtchikov, and V. Orlovich, Appl. Opt., 47, No. 3, 3549 (2008).
T. Hutchens, A. Darafsheh, A. Fardad, A. Antoszyk, H. Ying, V. Astratov, and N. Fried, J. Biomed. Opt., 19, No. 1, 018003-1–018003-8 (2014).
Y. Fukami and K. Awazu, Jpn. J. Appl. Phys., 42, No. 6, 3716–3721 (2015).
S. Suzuki-Yoshihashi, S. Yamada, I. Sato, and K. Awazu, Proc. SPIE, 6083, 60830I-1 (2006).
V. Serebryakov, É. Boiko, N. Petrishchev, and A. Yan, Opt. Zh., 77, No. 1, 9–23 (2010).
V. Tuchin, Lasers and Fiber Optics in Biomedical Investigations [in Russian], Fizmatlit (2010).
K. Hashimura, I. Katsunori, and A. Kunio, Jpn. J. Appl. Phys., 54, No. 11, 112701 (2015).
K. Hashimura, K. Ishii, N. Akikusa, T. Edamura, H. Yoshida, and K. Awazu, Trans. Jpn. Soc. Med. Biol. Eng., 51 (Supplement) R-178 (2013).
N. Masaki and S. Okazaki, Biomed. Opt. Express, 9, No. 5, 2095–2103 (2018).
S. Smye, J. Chamberlain, A. Fitzgerald, and E. Berry, Phys. Med. Biol., 46, No. 9, R101–R112 (2001).
R. Huber, F. Tauser, A. Brodschelm, M. Bichler, G. Abstreiter, and A. Leitenstorfer, Nature, 414, 286–289 (2001).
D. Bennett, Z. Taylor, P. Tewari, R. Singh, M. Culjat, W. Grundfest, and E. Brown, J. Biomed. Opt., 16, No. 5, 057003 (2011).
D. Mittleman, M. Gupta, R. Neelamani, R. Baraniuk, J. Rudd, and M. Koch, Appl. Phys. B, 68, No. 6, 1085–1094 (1999).
D. Crawley, C. Longbottom, V. Wallace, B. Cole, D. Arnone, and M. Pepper, J. Biomed. Opt., 8, No. 2, 303–308 (2003).
R. Woodward, P. Wallace, R. Pye, B. Cole, D. Arnone, E. Linfield, and M. Pepper, J. Invest. Dermatol., 120, No. 1, 72–78 (2003).
M. Lazebnik, D. Popovic, L. McCartney, C. Watkins, M. Lindstrom, J. Harter, and W. Temple, Phys. Med. Biol., 52, No. 20, 6093 (2007).
E. Pickwell, B. Cole, A. Fitzgerald, M. Pepper, and V. Wallace, Phys. Med. Biol., 49, No. 9, 1595 (2004).
R. Weissleder and M. Pittet, Nature, 452, No. 7187, 580 (2008).
D. Mittleman, R. Jacobsen, and M. Nuss, IEEE J. Sel. Top. Quantum Electron., 2, 679 (1996).
R. Woodward, B. Cole, V. Wallace, R. Pye, D. Arnone, E. Linfield, and M. Pepper, Phys. Med. Biol., 47, No. 21, 3853–3863 (2002).
P. Bolivar, M. Brucherseifer, M. Nagel, H. Kurz, A. Bosserhoff, and R. Büttner, Phys. Med. Biol., 47, 3815 (2002).
T. Chan, J. Bjarnason, A. Lee, M. Celis, and E. Brown, Appl. Phys. Lett., 85, 2523 (2004).
R. Köhler, A. Tredicucci, F. Beltram, H. Beere, E. Linfield, A. Davies, and F. Rossi, Nature, 417, No. 6885, 156 (2002).
C. Worrall, J. Alton, M. Houghton, S. Barbieri, H. Beere, D. Ritchie, and C. Sirtori, Opt. Express, 14, No. 1, 171–181 (2006).
G. Bellisola and C. Sorio, Am. J. Cancer Res., 2, No. 1, 1 (2012).
M. Kole, R. Reddy, M. Schulmerich, M. Gelber, and R. Bhargava, Anal. Chem., 84, 10366–10372 (2012).
N. Kröger-Lui, N. Gretz, K. Haase, B. Kränzlin, S. Neudecker, A. Pucci, and W. Petrich, Analyst, 140, No. 7, 2086–2092 (2015).
K. Haase, N. Kröger-Lui, A. Pucci, A. Schönhals, and W. Petrich, Faraday Discus., 187, 119–134 (2016).
P. Bassan, M. Weida, J. Rowlette, and P. Gardne, Analyst, 139, 3856–3859 (2014).
M. Pilling, A. Henderson, and P. Gardner, Anal. Chem., 89, 7348–7355 (2017).
M. Pilling, A. Henderson, B. Bird, M. Brown, N. Clarke, and P. Gardner, Faraday Discus., 187, 135–154 (2016).
D. Lasne, G. Blab, F. De Giorgi, F. Ichas, B. Lounis, and L. Cognet, Opt. Express, 15, 14184–14193 (2016).
A. Gaiduk, M. Yorulmaz, P. V. Ruijgrok, and M. Orrit, Science, 330, 353–356 (2010).
R. Furstenberg, C. A. Kendziora, M. R. Papantonakis, V. Nguyen, and R. McGill, Proc. SPIE, Defense, Security, and Sensing, Baltimore, MD, 9455, 945501 (2012).
A. Mërtiri, A. Totachawattana, H. Liu, M. K. Hong, T. Gardner, M. Y. Sander, and S. Erramilli, Conference on Lasers and Electro-Optics (CLEO’14), San Jose, CA, June 8–13, 2014 (2014).
M. Y. Sander, Mid-Infrared Photothermal Imaging, in Frontiers in Optics 2015, San Jose, CA, October 18–22, 2015 (2015).
G. Chebotareva, Laser Phys., 8, 941 (1998).
B. Wong, T. Milner, B. Anvari, A. Sviridov, A. Omel'chenko, V. Bagratashvili, E. Sobol, and J. Nelson, Laser. Med. Sci., 13, No. 1, 66–72 (1998).
L. Skvortsov and V. Kirillov, Kvantovaya Élektron., 33, No. 12, 1113–1117 (2003).
V. Kirillov and L. Skvortsov, Kvantovaya Élektron., 36, No. 8, 797–799 (2006).
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Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 86, No. 1, pp. 5–32, January–February, 2019.
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Abramov, P.I., Kuznetsov, E.V., Skvortsov, L.A. et al. Quantum-Cascade Lasers in Medicine and Biology (Review). J Appl Spectrosc 86, 1–26 (2019). https://doi.org/10.1007/s10812-019-00775-8
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DOI: https://doi.org/10.1007/s10812-019-00775-8