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A Comparative Study between Carcinoma and Sarcoma Using Raman Spectroscopy

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Journal of Applied Spectroscopy Aims and scope

The purpose of this study was to find discriminating Raman spectral features between two major types of cancer, i.e., carcinoma and sarcoma. To this end, Raman spectra from adenocarcinoma, liposarcoma and fibrosarcoma samples were compared. A Raman system was used for the tissue Raman spectroscopic measurements at 785-nm laser excitation. After pre-processings, the Raman spectra were investigated, in major bands associated with protein and lipids, in the adenocarcinoma, liposarcoma, and fibrosarcoma groups. Principal component analysis and nonnegative matrix factorization were performed for finding most significant features in discriminating the spectra of carcinoma from those of sarcoma samples. The findings of this study show that the lipid content in the sarcoma samples decreases compared with the carcinoma samples. The achieved accuracy in discriminating carcinoma from sarcoma by linear discriminant analysis is 93.75 % and 90.63 % using the first nine principal components and nonnegative matrix factorization analysis, respectively.

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Authors and Affiliations

  1. Tarbiat Modares University, Tehran, Iran

    Z. Dehghani-Bidgoli, M. H. Miran Baygi, E. Kabir & R. Malekfar

Authors
  1. Z. Dehghani-Bidgoli
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  2. M. H. Miran Baygi
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  3. E. Kabir
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  4. R. Malekfar
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Correspondence to M. H. Miran Baygi.

Additional information

Published in Zhurnal Prikladnoi Spektroskopii, Vol. 80, No. 6, pp. 901–906, November–December, 2013.

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Dehghani-Bidgoli, Z., Baygi, M.H.M., Kabir, E. et al. A Comparative Study between Carcinoma and Sarcoma Using Raman Spectroscopy. J Appl Spectrosc 80, 893–898 (2014). https://doi.org/10.1007/s10812-014-9861-5

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  • DOI: https://doi.org/10.1007/s10812-014-9861-5

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