Skip to main content

Effect of extracorporeal ultraviolet blood irradiation on blood cholesterol level

We have studied the effect of extracorporeal ultraviolet blood irradiation on cholesterol metabolism in patients with cardiovascular diseases. We have carried out a comprehensive analysis of the spectral characteristics of blood and plasma, gas-exchange and oximetry parameters, and the results of a complete blood count and chemistry panel before and after UV blood irradiation. We have assessed the changes in concentrations of cholesterols (total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides) in the blood of the patients in response to a five-day course of UV blood irradiation. The changes in the spectral characteristics of blood and plasma, the chemistry panel, the gas composition, and the fractional hemoglobin composition initiated by absorption of UV radiation are used to discuss the molecular mechanisms for the effect of therapeutic doses of UV radiation on blood cholesterols.

This is a preview of subscription content, access via your institution.


  1. E. Knott, Am. J. Surgery, 76, No. 2, 165–171 (1948).

    Article  Google Scholar 

  2. V. I. Karandashov and E. B. Petukhov, Ultraviolet Blood Irradiation [in Russian], Meditsina, Moscow (1997).

    Google Scholar 

  3. I. G. Dutkevich, G. V. Golovin, K. A. Samoilova, and Yu. P. Popov, in: Mechanisms for the Effect of UV-Irradiated Blood on the Human Body and in Animals [in Russian], Nauka, Leningrad (1986), pp. 18–25.

  4. D. I. Roshchupkin and M. A. Murina, Biofizika, 38, No. 6, 1053–1068 (1993).

    Google Scholar 

  5. Yu. A. Vladimirov and A. I. Archakov, Lipid Peroxidation in Biological Membranes [in Russian], Nauka, Moscow (1972).

    Google Scholar 

  6. U. P. Steibrecher, S. Parthasarathy, D. S. Leake, J. L. Witztum, and D. Steinberg, Proc. Nat. Acad. Sci., 81, 3383–3387 (1984).

    Google Scholar 

  7. Kan-Zhi Liu, R. A. Shaw, A. Man, T. C. Dembinski, and N. N. Mantsch, Clinic. Chem., 48, 499–506 (2002).

    Google Scholar 

  8. G. A. Zalesskaya and V. S. Ulashchik, Zh. Prikl. Spektrosk., 76, No. 1, 51–75 (2009).

    Google Scholar 

  9. G. A. Zalesskaya, V. S. Ulashchik, and I. I. Kalosha, Opt. Spektrosk., 107, No. 4, 695–702 (2009).

    Article  Google Scholar 

  10. G. A. Zalesskaya and T. O. Maslova, Opt. Spektrosk., 109, 337-343 (2011).

    Google Scholar 

  11. N. K. Zenkov, V. Z. Lankin, and E. B. Men’shchikova, Oxidative Stress: Biochemical and Pathophysiological Aspects [in Russian], Nauka/Interperiodika, Moscow (2001).

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to G. A. Zalesskaya.

Additional information

Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 79, No. 3, pp. 465–470, May–June, 2012.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Zalesskaya, G.A., Laskina, O.V., Mitkovskaya, N.P. et al. Effect of extracorporeal ultraviolet blood irradiation on blood cholesterol level. J Appl Spectrosc 79, 446–452 (2012).

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI:


  • ultraviolet blood irradiation
  • absorption spectra of blood and plasma in the UV-visible and IR ranges
  • cholesterol
  • low-density lipoprotein (LDL) cholesterol
  • level of hemoglobin oxygen saturation
  • active oxygen species