IR Fourier spectra of pharmacologically active sterically hindered phenols in CCl4 solutions are studied. A relationship between the absorption intensity in the spectral range of the free vibrations of OH-groups and the antimicrobial activity of the phenols is discovered. If the hydroxyl groups are in an ortho-position within a molecule, then intramolecular hydrogen bonds are formed. The hindered phenols with nonassociated hydroxyl groups are the most pharmacologically active.
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Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 78, No. 3, pp. 427–432, May–June, 2011.
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Belkov, M.V., Polozov, G.I., Skornyakov, I.V. et al. Infrared spectra and pharmacological activity of hindered phenols. J Appl Spectrosc 78, 400–405 (2011). https://doi.org/10.1007/s10812-011-9472-3
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DOI: https://doi.org/10.1007/s10812-011-9472-3