Analysis of IR-Fourier spectra from solutions and crystals of antiviral sulfo-containing aminophenols has shown that various types of intramolecular and intermolecular interactions can occur in molecules of these compounds. Three types of intramolecular hydrogen bonds (O–H⋅⋅⋅N, O–H⋅⋅⋅O=S=O, and N–H⋅⋅⋅O=S=O) are formed in CCl4 solutions of the sulfo-containing aminophenols. The formation of intermolecular H-bonds involving the NH- and OH-groups and the preservation of the intramolecular O–H⋅⋅⋅O=S=O H-bond are characteristic of the anti-HIV active aminophenol crystals. Spectral attributes are determined in order to distinguish between the anti-HIV active and inactive sulfo-containing aminophenols.
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Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 78, No. 2, pp. 215–221, March–April, 2011.
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Belkov, M.V., Ksendzova, G.A., Skornyakov, I.V. et al. Hydrogen bonds of anti-HIV active aminophenols. J Appl Spectrosc 78, 197–202 (2011). https://doi.org/10.1007/s10812-011-9446-5
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DOI: https://doi.org/10.1007/s10812-011-9446-5