Abstract
We have studied the sensitivity of the correlation between the unidirectional scattering coefficients β(θ) and the microphysical parameters of erythrocytes in human blood the number concentration (N) and the volume concentration (CV), the modal radius (r), and the half-width (Δr) of the size distribution function of the erythrocytes, the real part of their refractive indices n) to variations of the latter in the ranges of their possible values at wavelengths λ = 0.3–1.2 µm. We have obtained the multiple regression equations for the microphysical parameters and β(θ) in the transparency window of blood (λ = 0.65 µm). We have shown that the procedure for determining the microphysical parameters, based on these equations, allows us to rapidly determine the microphysical parameters rapidly and highly accurately within their possible ranges.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. Gitter and L. Heilmeyer, eds., Handbook of Clinical Function Tests [Russian translation from German by N. P. Vel’min], Meditsina, Moscow (1966).
K. M. Abdulkadyrov, S. S. Bessmel’tsev, and N. Yu. Lyubimova, Terapevt. Arkhiv, No. 7, 125–128 (1991).
Z. D. Fedorova, K. M. Abdulkadyrov, S. S. Bessmel’tsev, and M. A. Kotovshchikova, Gematologiya i Transfuziologiya, No. 2, 12–17 (1989).
V. N. Lopatin, A. V. Priezzhev, A. Yu. Afanasenko, et al., Light Scattering Methods in Analysis of Disperse Biological Media [in Russian], FIZMATLIT, Moscow (2004).
L. S. Ivlev and Yu. A. Dovgalyuk, The Physics of Atmospheric Aerosol Systems [in Russian], NIIKh SPbGU, St. Petersburg (1999).
V. E. Zuev and I. E. Naats, Inverse Problems of Atmospheric Optics [in Russian], Gidrometeoizdat, Leningrad (1990).
A. Ya. Khairullina, “Diagnostics of optical and biophysical parameters of blood and other biological tissues by light scattering methods,” Dissertation in competition for the academic degree of Physical-Mathematical Sciences, Minsk (1998).
C. F. Boren and D. R. Huffman, Absorption and Scattering of Light by Small Particles [in Russian], Mir, Moscow (1986).
V. V. Lopatin, A. V. Priezzhev, and V. V. Fedoseev, Biomed. Radioelektronika, 7, No. 29 (2000).
A. N. Yaroslavsky, T. Goldbach, and H. J. Schwarzmaier, J. Biomed. Opt., 4, No. 47, 1175–1187 (1999).
A. Rogan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt., 4, No. 36, 1270–1284 (1999).
A. Ya. Khairullina and S. F. Shumilina, Zh. Prikl. Spektr., 19, No. 2, 340–347 (1973).
I. A. Kassirskii and G. A. Alekseev, Clinical Methodology [in Russian], Meditsina, Moscow (1970).
A. N. Okorokov, Diagnosis of Diseases of the Internal Organs. Vol. 4. Diagnosis of Blood Diseases [in Russian], Med. Lit., Moscow (2003).
E. K. Naumenko, “Change in the optical properties of blood during aggregation of erythrocytes,” Preprint No. 736, Institute of Physics, National Academy of Sciences of Belarus, Minsk (2001).
V. A. Kolemaev and V. N. Kalinina, Probability Theory and Mathematical Statistics [in Russian], INFRA-M, Moscow (1997).
A. S. Monin, ed., Ocean Optics. Vol. 1. Physical Optics of the Ocean [in Russian], Nauka, Moscow (1983).
M. Hammer, A. N. Yaroslavsky, and D. Schweitzer, Physics in Medicine and Biology, 46, No. 65 (2001).
A. F. Aleksandrov, D. A. Svistov, and I. B. Timofeev, Biomed. Radioelektronika, No. 5, 50–64 (2000).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 74, No. 5, pp. 652–658, September–October, 2007.
Rights and permissions
About this article
Cite this article
Kugeiko, M.M., Lysenko, S.A. Determination of microphysical parameters of erythrocytes in human blood from laser radiation scattering. J Appl Spectrosc 74, 723–730 (2007). https://doi.org/10.1007/s10812-007-0116-6
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10812-007-0116-6