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A concise review of the potential utilization based on bioactivity and pharmacological properties of the genus Gelidium (Gelidiales, Rhodophyta)

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Abstract

Being an agarophyte, Gelidium is extensively exploited for its agar-producing capacity. However, the food value and medicinal importance of this red alga are not to be underestimated. The pharmacological properties of Gelidium species have potential for the pharmaceutical, nutraceutical and cosmeceutical industries. This review collects, identifies and analyzes comprehensively the studies that deal with the bioactive properties of Gelidium species in the last decade. The principal bioactive compounds of Gelidium include R-phycoerythrin, R-phycocyanin, alkaloids, terpenoids, tannins, flavonoids, saponins, coumarins, cardiac glycosides, and steroids. Gelidium in the form of extracts or isolated compounds have been reported to show antibacterial, antioxidant, anticancer, anti-inflammatory, anti-obesity, immunomodulatory, neuroprotective, and antidiabetic properties. Most of the evidence has been reported in various in vitro models. Therefore, further experiments using appropriate animal and human subjects are necessary to develop the preclinical findings into clinical use. The main challenge in developing bioactive compounds on a commercial scale is the sustainable supply of Gelidium biomass that requires integrated seaweed aquaculture through employing biotechnological approaches and effective utilization of industrial byproducts.

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Data Availability

Data supporting reported results are available upon request.

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Acknowledgements

The authors thank Pukyong National University, Silla University and Dongguk University, South Korea for the international collaboration.

Funding

This research was funded by Indonesian Ministry of Education, Culture, Research and Technology under Scheme for Academic Mobility and Exchange (SAME) number 109/D2.3/KK.0403.

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Authors and Affiliations

  1. Faculty of Fisheries and Marine Science, Jenderal Soedirman University, Purwokerto, 53123, Indonesia

    Maria Dyah Nur Meinita &  Amron

  2. Center for Maritime Bioscience Studies, Jenderal Soedirman University, Purwokerto, 53123, Indonesia

    Maria Dyah Nur Meinita

  3. Faculty of Fisheries and Marine Science, Diponegoro University, Semarang, 50275, Indonesia

    Dicky Harwanto

  4. Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh

    Md. Abdul Hannan

  5. Department of Biotechnology, Pukyong National University, Busan, 48513, Korea

    Gwi-Taek Jeong

  6. Department of Anatomy, College of Medicine, Dongguk University, Gyeongju, 38066, Republic of Korea

    Il Soo Moon

  7. Department of Seafood Science and Technology, The Institute of Marine Industry, Gyeongsang National University, 38 Cheondaegukchi-Gil, Tongyeong-Si, 53064, Gyeongsangnam-Do, Korea

    Jae-Suk Choi

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  1. Maria Dyah Nur Meinita
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Contributions

M.D.N.M: Investigation, Data curation, Analysis, Validation, Visualization, Writing—original draft; A, D.H and M.A.H: Investigation, Data curation, Writing—review & editing; J.-S.C: Conceptualization, Supervision, Methodology, Writing—review & editing; G.-T.J and I.-S.M: Investigation, Data curation, Supervision, Methodology, Writing—review & editing.

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Correspondence to Maria Dyah Nur Meinita.

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Meinita, M.D.N., Harwanto, D., Amron et al. A concise review of the potential utilization based on bioactivity and pharmacological properties of the genus Gelidium (Gelidiales, Rhodophyta). J Appl Phycol 35, 1499–1523 (2023). https://doi.org/10.1007/s10811-023-02956-7

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