Bioactive compounds in seaweed: functional food applications and legislation

Abstract

Seaweed is more than the wrap that keeps rice together in sushi. Seaweed biomass is already used for a wide range of other products in food, including stabilising agents. Biorefineries with seaweed as feedstock are attracting worldwide interest and include low-volume, high value-added products and vice versa. Scientific research on bioactive compounds in seaweed usually takes place on just a few species and compounds. This paper reviews worldwide research on bioactive compounds, mainly of nine genera or species of seaweed, which are also available in European temperate Atlantic waters, i.e. Laminaria sp., Fucus sp., Ascophyllum nodosum, Chondrus crispus, Porphyra sp., Ulva sp., Sargassum sp., Gracilaria sp. and Palmaria palmata. In addition, Undaria pinnatifida is included in this review as this is globally one of the most commonly produced, investigated and available species. Fewer examples of other species abundant worldwide have also been included. This review will supply fundamental information for biorefineries in Atlantic Europe using seaweed as feedstock. Preliminary selection of one or several candidate seaweed species will be possible based on the summary tables and previous research described in this review. This applies either to the choice of high value-added bioactive products to be exploited in an available species or to the choice of seaweed species when a bioactive compound is desired. Data are presented in tables with species, effect and test organism (if present) with examples of uses to enhance comparisons. In addition, scientific experiments performed on seaweed used as animal feed are presented, and EU, US and Japanese legislation on functional foods is reviewed.

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References

  1. Aisa Y, Miyakawa Y, Nakazato T, Shibata H, Saito K, Ikeda Y, Kizaki M (2005) Fucoidan induces apoptosis of human HS-Sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways. Am J Hematol 78:7–14

    Google Scholar 

  2. Alekseyenko TV, Zhanayeva SY, Venediktova AA, Zvyagintseva TN, Kuznetsova TA, Besednova NN, Korolenko TA (2007) Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk sea Fucus evanescens brown alga. Bull Exp Biol Med 143:730–732

    PubMed  CAS  Article  Google Scholar 

  3. Almela C, Algora S, Benito V, Clemente MJ, Devesa V, Suner MA, Velez D, Montoro R (2002) Heavy metal, total arsenic, and inorganic arsenic contents of algae food products. J Agric Food Chem 50:918–923

    PubMed  CAS  Article  Google Scholar 

  4. Amano H, Kakinuma M, Coury DA, Ohno H, Hara T (2005) Effect of a seaweed mixture on serum lipid level and platelet aggregation in rats. Fish Sci 71:1160–1166

    CAS  Article  Google Scholar 

  5. Andersson L, Lidgren G, Bohlin L, Magni L, Ogren S, Afzelius L (1983) Studies of Swedish marine organisms. 1. Screening of biological-activity. Act Pharm Suec 20:401–414

    CAS  Google Scholar 

  6. Aneiros A, Garateix A (2004) Bioactive peptides from marine sources: pharmacological properties and isolation procedures. J Chromatogr B Analyt Technol Biomed Life Sci 803:41–53

    PubMed  CAS  Article  Google Scholar 

  7. Arasaki S, Arasaki T (1983) Low calorie, high nutrition vegetables from the sea to help you look and feel better. Japan Publications, Tokyo, 196 pp

    Google Scholar 

  8. Archer GS (2005) Reducing stress in sheep by feeding the seaweed Ascophyllum nodosum. Texas A&M University, 129 pp

  9. Arnold TM, Targett NM (2000) Evidence for metabolic turnover of polyphenolics in tropical brown algae. J Chem Ecol 26:1393–1410

    CAS  Article  Google Scholar 

  10. Arts ICW, Hollman PCH, De Mesquita HBB, Feskens EJM, Kromhout D (2001) Dietary catechins and epithelial cancer incidence: the Zutphen Elderly Study. Int J Cancer 92:298–302

    PubMed  CAS  Article  Google Scholar 

  11. Astorg P (1997) Food carotenoids and cancer prevention: an overview of current research. Trends Food Sci Technol 8:406–413

    CAS  Article  Google Scholar 

  12. Athukorala Y, Lee KW, Kim SK, Jeon YJ (2007) Anticoagulant activity of marine green and brown algae collected from Jeju Island in Korea. Bioresour Technol 98:1711–1716

    PubMed  CAS  Article  Google Scholar 

  13. Augier H, Santimone M (1978) Contribution to study of composition in total nitrogen, proteins and proteinic amino-acids of different parts of thallus of Laminaria digitata (Huds) Lamour in scope of its industrial and agricultural exploitation. Bull Soc Phyc France 110:19–28

    Google Scholar 

  14. Baardseth E (1958) A method of estimating the physode content in brown algae-reprint of report 20. Papers Presented at the Third International Seaweed Symposium by the Staff of the Norwegian Institute of Seaweed Research, Norwegian Institute of Seaweed Research, Trondheim. Report 20, pp 1–6

  15. Baardseth E, Haug A (1953) Individual variation of some constituents in brown algae, and reliability of analytical results. Norwegian Institute of Seaweed Research, Akademisk Trykningssentral, Oslo. Report 2, pp 1–23

  16. Bansemir A, Blume M, Schröder S, Lindequist U (2006) Screening of cultivated seaweeds for antibacterial activity against fish pathogenic bacteria. Aquaculture 252:79–84

    Article  Google Scholar 

  17. Barbarino E, Lourenço S (2005) An evaluation of methods for extraction and quantification of protein from marine macro- and microalgae. J Appl Phycol 17:447–460

    CAS  Article  Google Scholar 

  18. Bartsch I, Wienke C, Bischof K, Buchholz CM, Buck BH, Eggert A, Feuerpfeil P, Hanelt D, Jacobsen S, Karez R et al (2008) The genus Laminaria sensu lato: recent insights and developments. Eur J Phycol 43:1–86

    Article  Google Scholar 

  19. Benvegnu T, Sassi J-F (2010) Oligomannuronates from seaweeds as renewable sources for the development of green surfactants. Top Curr Chem 294:143–164

    Google Scholar 

  20. Berteau O, Mulloy B (2003) Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology 13:29R–40R

    PubMed  CAS  Article  Google Scholar 

  21. Besada V, Andrade JM, Schultze F, Gonzalez JJ (2009) Heavy metals in edible seaweeds commercialised for human consumption. J Mar Syst 75:305–313

    Article  Google Scholar 

  22. Bhakuni DS, Rawat DS (2005) Bioactive metabolites of marine algae, fungi and bacteria. In: Bioactive marine natural products. Co-published by Anamaya Publishers and Springer, New Delhi, pp 1–25

  23. Bhaskar N, Hosokawa M, Miyashita K (2004) Comparative evaluation of fatty acid composition of different Sargassum (Fucales, Phaeophyta) species harvested from temperature and tropical waters. J Aquat Food Prod Technol 3:53–70

    Google Scholar 

  24. Bird KT, Chiles TC, Longley RE, Kendrick AF, Kinkema MD (1993) Agglutinins from marine macroalgae of the southeastern United States. J Appl Phycol 5:213–218

    CAS  Article  Google Scholar 

  25. Bitencourt FD, Figueiredo JG, Mota MRL, Bezerra CCR, Silvestre PP, Nascimento VMR, KS SAH, Nagano CS, Saker-Sampaio S et al (2008) Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis. Naunyn-Schmiedebergs Arch Pharmacol 377:139–148

    CAS  Article  Google Scholar 

  26. Bixler HJ, Porse H (2010) A decade of change in the seaweed hydrocolloids industry. J Appl Phycol. doi:10.1007/s10811-010-9529-3

  27. Black WAP (1950) The seasonal variation in the cellulose content of the common Scottish Laminariaceae and Fucaceae. J Mar Biol Assoc UK 29:379–387

    Article  Google Scholar 

  28. Blunt JW, Copp BR, Munro MHG, Northcote PT, Prinsep MR (2003) Marine natural products. Nat Prod Rep 20:1–48

    PubMed  CAS  Article  Google Scholar 

  29. Bobin-Dubigeon C, Lahaye M, Barry JL (1997) Human colonic bacterial degradability of dietary fibres from sea-lettuce (Ulva sp.). J Sci Food Agric 73:149–159

    CAS  Article  Google Scholar 

  30. Bogentoff CB (1981) Antacid composition for neutralizing stomach acid. Germany Patent No. 2,722,484

  31. Borgo E (1984) Pharmaceutical compositions for the treatment of gastric hyperacidity, gastritis and gastroduodenal ulcers. Canada Patent No. 1,176,984

  32. Boubonari T, Malea P, Kevrekidis T (2008) The green seaweed Ulva rigida as a bioindicator of metals (Zn, Cu, Pb and Cd) in a low-salinity coastal environment. Bot Mar 51:472–484

    CAS  Article  Google Scholar 

  33. Brito I, Cueto M, Díaz-Marrero AR, Darias J, Martin AS (2002) Oxachamigrenes, new halogenated sesquiterpenes from Laurencia obtusa. J Nat Prod 65:946–948

    PubMed  CAS  Article  Google Scholar 

  34. Bruhn A, Rasmussen MB, Olesen B, Worm T (2008) Kommerciel dyrkning af carrageentang (Chondrus crispus) i danske farvande. Danmarks Miljøundersøgelser, Silkeborg, 62 pp (in Danish)

    Google Scholar 

  35. Buck CB, Thompson CD, Roberts JN, Muller M, Lowy DR, Schiller JT (2006) Carrageenan is a potent inhibitor of papillomavirus infection. PLoS Pathog 2:671–680

    CAS  Article  Google Scholar 

  36. Burtin P (2003) Nutritional value of seaweeds. Electron J Environ Agric Food Chem 2:498–503

    Google Scholar 

  37. Butler A, Carter-Franklin JN (2004) The role of vanadium bromoperoxidase in the biosynthesis of halogenated marine natural products. Nat Prod Rep 21:180–188

    PubMed  CAS  Article  Google Scholar 

  38. Caceres PJ, Carlucci MJ, Damonte EB, Matsuhiro B, Zuniga EA (2000) Carrageenans from Chilean samples of Stenogramme interrupta (Phyllophoraceae): structural analysis and biological activity. Phytochemistry 53:81–86

    PubMed  CAS  Article  Google Scholar 

  39. Cann SAH (2006) Hypothesis: dietary iodine intake in the etiology of cardiovascular disease. J Am Coll Nutr 25:1–11

    Google Scholar 

  40. Cardozo KHM, Guaratini T, Barros MP, Falcão VR, Tonon AP, Lopes NP, Campos S, Torres MA, Souza AO, Colepicolo P et al (2007) Metabolites from algae with economical impact. Comp Biochem Physiol C: Toxicol Pharmacol 146:60–78

    Article  CAS  Google Scholar 

  41. Carlucci MJ, Pujol CA, Ciancia M, Noseda MD, Matulewicz MC, Damonte EB, Cerezo AS (1997) Antiherpetic and anticoagulant properties of carrageenans from the red seaweed Gigartina skottsbergii and their cyclized derivatives: correlation between structure and biological activity. Int J Biol Macromol 20:97–105

    PubMed  CAS  Article  Google Scholar 

  42. Carthew P (2002) Safety of carrageenan in foods. Environ Health Perspect 110:A176

    PubMed  Article  Google Scholar 

  43. Carvalho MDT, Harada LM, Gidlund M, Ketelhuth DFJ, Boschcov P, Quintao ECR (2002) Macrophages take up triacylglycerol-rich emulsions at a faster rate upon co-incubation with native and modified LDL: an investigation on the role of natural chylomicrons in atherosclerosis. J Cell Biochem 84:309–323

    PubMed  Article  CAS  Google Scholar 

  44. Cérantola S, Breton F, Ar Gall E, Deslandes E (2006) Co-occurrence and antioxidant activities of fucol and fucophlorethol classes of polymeric phenols in Fucus spiralis. Bot Mar 49:347–351

    Article  CAS  Google Scholar 

  45. Cha SH, Ahn GN, Heo SJ, Kim KN, Lee KW, Song CB, Cho SK, Jeon YJ (2006) Screening of extracts from marine green and brown algae in Jeju for potential marine angiotensin-I converting enzyme (ACE) inhibitory activity. J Korean Soc Food Sci Nutr 35:307–314

    Article  Google Scholar 

  46. Chapman VJ (1970) Seaweeds and their uses, 2nd edn. Methuen, London, 304 pp

    Google Scholar 

  47. Chen H-M, Zheng L, Yan X-J (2005) The preparation and bioactivity research of agaro-oligosaccharides. Food Technol Biotechnol 43:29–36

    CAS  Google Scholar 

  48. Chernomorsky S, Segelman A, Poretz RD (1999) Effect of dietary chlorophyll derivatives on mutagenesis and tumor cell growth. Tera Carc Mut 19:313–322

    CAS  Article  Google Scholar 

  49. Chevolot L, Foucault A, Chaubet F, Kervarec N, Sinquin C, Fisher AM, Boisson-Vidal C (1999) Further data on the structure of brown seaweed fucans: relationships with anticoagulant activity. Carbohydr Res 319:154–165

    PubMed  CAS  Article  Google Scholar 

  50. Cho SH, Kang SE, Cho JY, Kim AR, Park SM, Hong YK, Ahn DH (2007) The antioxidant properties of brown seaweed (Sargassum siliquastrum) extracts. J Med Food 10:479–485

    PubMed  CAS  Article  Google Scholar 

  51. Choi YS, Hong SR, Lee YM, Song KW, Park MH, Nam YS (1999) Study on gelatin-containing artificial skin: I. Preparation and characteristics of novel gelatin–alginate sponge. Biomaterials 20:409–417

    PubMed  CAS  Article  Google Scholar 

  52. Chopin T, Gallant T, Davison I (1995) Phosphorus and nitrogen nutrition in Chondrus crispus (Rhodophyta): effects on total phosphorus and nitrogen content, carrageenan production, and photosynthetic pigments and metabolism. J Phycol 31:283–293

    CAS  Article  Google Scholar 

  53. Chopin T, Sharp G, Belyea E, Semple R, Jones D (1999) Open-water aquaculture of the red alga Chondrus crispus in Prince Edward Island, Canada. Hydrobiologia 398/399:417–425

    Article  Google Scholar 

  54. Chronakis IS, Galatanu AN, Nylander T, Lindman B (2000) The behaviour of protein preparations from blue-green algae (Spirulina platensis strain Pacifica) at the air/water interface. Colloid Surface Physicochem Eng Aspect 173:181–192

    CAS  Article  Google Scholar 

  55. Cloughley G, Burbridge E, Kraan S, Guiry MD, Smyth PPA (2008) Iodine uptake and efflux by macroalgae. 11th International Conference on Applied Phycology, Galway, Ireland, p 81

  56. Connan S, Goulard F, Stiger V, Deslandes E, Ar Gall E (2004) Interspecific and temporal variation in phlorotannin levels in an assemblage of brown algae. Bot Mar 47:410–416

    CAS  Article  Google Scholar 

  57. Connan S, Delisle F, Deslandes E, Ar Gall E (2006) Intra-thallus phlorotannin content and antioxidant activity in Phaeophyceae of temperate waters. Bot Mar 49:39–46

    CAS  Article  Google Scholar 

  58. Constantinides P, Cairns A, Werner A (1954) Antilipemic activity of sulfated polysaccharides. Arch Int Pharmacodyn Thér 99:334–345

    PubMed  CAS  Google Scholar 

  59. Cornish ML, Garbary DJ (2010) Antioxidants from macroalgae: potential applications in human health and nutrition. Algae 25:000–000. doi:10.4490/algae.2010.25.4.000

    Google Scholar 

  60. Craigie JS (2010) Seaweed extract stimuli in plant science and agriculture. J Appl Phycol. doi:10.1007/z10811-010-9560-4

  61. Cruz-Uribe O, Cheney DP, Rorrer GL (2007) Comparison of TNT removal from seawater by three marine macroalgae. Chemosphere 67:1469–1476

    PubMed  CAS  Article  Google Scholar 

  62. Dannhardt G, Kiefer W (2001) Cyclooxygenase inhibitors—current status and future prospects. Eur J Med Chem 36:109–126

    PubMed  CAS  Article  Google Scholar 

  63. Darias J, Rovirosa J, San Martin A, Diaz AR, Dorta E, Cueto M (2001) Furoplocamioids A-C, novel polyhalogenated furanoid monoterpenes from Plocamium cartilagineum. J Nat Prod 64:1383–1387

    PubMed  CAS  Article  Google Scholar 

  64. Dawczynski C, Schubert R, Jahreis G (2007) Amino acids, fatty acids, and dietary fibre in edible seaweed products. Food Chem 103:891–899

    CAS  Article  Google Scholar 

  65. Dembitsky VM, Rozentsvet OA (1990) Phospholipid composition of some marine red algae. Phytochemistry 29:3149–3152

    Article  Google Scholar 

  66. Dembitsky VM, Srebnik M (2002) Natural halogenated fatty acids: their analogues and derivatives. Prog Lipid Res 41:315–367

    PubMed  CAS  Article  Google Scholar 

  67. Dembitsky VM, Rozentsvet OA, Pechenkina EE (1990) Glycolipids, phospholipids and fatty-acids of brown-algae species. Phytochemistry 29:3417–3421

    CAS  Article  Google Scholar 

  68. Dembitsky VM, Pechenkinashubina EE, Rozentsvet OA (1991) Glycolipids and fatty-acids of some seaweeds and marine grasses from the Black Sea. Phytochemistry 30:2279–2283

    CAS  Article  Google Scholar 

  69. Deville C, Damas J, Forget P, Dandrifosse G, Peulen O (2004) Laminarin in the dietary fibre concept. J Sci Food Agric 84:1030–1038

    CAS  Article  Google Scholar 

  70. Deville C, Gharbi M, Dandrifosse G, Peulen O (2007) Study on the effects of laminarin, a polysaccharide from seaweed, on gut characteristics. J Sci Food Agric 87:1717–1725

    CAS  Article  Google Scholar 

  71. Dierick N, Ovyn A, De Smet S (2009) Effect of feeding intact brown seaweed Ascophyllum nodosum on some digestive parameters and on iodine content in edible tissues in pigs. J Sci Food Agric 89:584–594

    CAS  Article  Google Scholar 

  72. Dietrich CP, Farias GGM, de Abreu LRD, Leite EL, da Silva LF, Nader HB (1995) A new approach for the characterization of polysaccharides from algae: presence of four main acidic polysaccharides in three species of the class Phaeophyceae. Plant Sci 108:143–153

    CAS  Article  Google Scholar 

  73. Doh-ura K, Kuge T, Uomoto M, Nishizawa K, Kawasaki Y, Iha M (2007) Prophylactic effect of dietary seaweed fucoidan against enteral prion infection. Antimicrob Agents Chemother 51:2274–2277

    PubMed  CAS  Article  Google Scholar 

  74. Doi K, Tsuji K (1998) Dietary fibers: basics and critics. Asakura Shoten, Tokyo, 426 pp (in Japanese)

    Google Scholar 

  75. Douady D, Rousseau B, Caron L (1994) Fucoxanthin-chlorophyll a/c light-harvesting complexes of Laminaria saccharina: partial amino acid sequences and arrangement in thylakoid membranes. Biochemistry 33:3165–3170

    PubMed  CAS  Article  Google Scholar 

  76. Doyle JW, Roth TP, Smith RM, Li YQ, Dunn RM (1996) Effect of calcium alginate on cellular wound healing processes modeled in vitro. J Biomed Mater Res 32:561–568

    PubMed  CAS  Article  Google Scholar 

  77. Dubber D, Harder T (2008) Extracts of Ceramium rubrum, Mastocarpus stellatus and Laminaria digitata inhibit growth of marine and fish pathogenic bacteria at ecologically realistic concentrations. Aquaculture 274:196–200

    Article  Google Scholar 

  78. Dumelod BD, Ramirez RPB, Tiangson CLP, Barrios EB, Panlasigui LN (1999) Carbohydrate availability of arroz caldo with lambda-carrageenan. Int J Food Sci Nutr 50:283–289

    PubMed  CAS  Article  Google Scholar 

  79. Durcan J, Cave R, Tyrrell L, McGovern, Stengel DB (2010) Arsenic levels in selected red, green and brown macroalgae from Western Ireland. XX Seaweed Symposium, p 121

  80. Durig J, Bruhn T, Zurborn KH, Gutensohn K, Bruhn HD, Beress L (1997) Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 85:479–491

    PubMed  CAS  Article  Google Scholar 

  81. Dworjanyn SA, Pirozzi I, Liu W (2007) The effect of the addition of algae feeding stimulants to artificial diets for the sea urchin Tripneustes gratilla. Aquaculture 273:624–633

    Article  Google Scholar 

  82. European Advisory Services (EAS) (2008) Marketing food supplements, fortified and functional foods in Europe. Legislation and practice 2008, 250 pp

  83. EAS (2009) Regulation 1170/2009 amending Directive 2002/46/EC and Regulation 1925/2006 as regards the lists of vitamin and minerals and their forms that can be added to foods, including food supplements. http://www.eas.eu/Legislation.aspx?download=56, accessed 6 April 2010

  84. Ellouali M, Boissonvidal C, Durand P, Jozefonvicz J (1993) Antitumor-activity of low-molecular-weight fucans extracted from brown seaweed Ascophyllum nodosum. Anticancer Res 13:2011–2019

    PubMed  CAS  Google Scholar 

  85. Ennamany R, Saboureau D, Mekideche N, Creppy EE (1998) SECMA 1 (R), a mitogenic hexapeptide from Ulva algeae modulates the production of proteoglycans and glycosaminoglycans in human foreskin fibroblast. Hum Exp Toxicol 17:18–22

    PubMed  CAS  Article  Google Scholar 

  86. Enoki T, Sagawa H, Tominaga T, Nishiyama E, Komyama N, Sakai T, Yu FG, Ikai K, Kato I (2003) Drugs, foods or drinks with the use of algae-derived physiologically active substances. US Patent 0,105,029

  87. Ergün S, Soyutürk M, Güroy B, Güroy D, Merrifield D (2008) Influence of Ulva meal on growth, feed utilization, and body composition of juvenile Nile tilapia (Oreochromis ániloticus) at two levels of dietary lipid. Aquac Int 17:355–361

    Article  CAS  Google Scholar 

  88. EU (2008) Kommisionens forordning (EF) Nr. 629/2008, af 2. juli 2008, om ændring af forordning (EF) nr. 1881/2006 om fastsættelse af grænseværdier for bestemte forurenende stoffer i fødevarer. Den Europæiske Unions Tidende, pp 6–9 (in Danish)

  89. European Commission (1997) Novel Food Catalogue. http://ec.europa.eu/food/food/biotechnology/novelfood/nfnetweb/mod_search/index.cfm on December 14 2010

  90. Fan D, Hodges DM, Zhang J, Kirby CW, Ji X, Locke SJ, Critchley AT, Prithiviraj B (2011) Commercial extract of the brown seaweed Ascophyllum nodosum enhances phenolic antioxidant content of spinach (Spinacia oleracea L.) which protects Caenorhabditis elegans against oxidative and thermal stress. Food Chem 124:195–202

    Google Scholar 

  91. FAO (2008) FAO statistics. http://wwwfaoorg/figis/servlet/static?dom=root&xml=aquaculture/indexxml, accessed 2 February 2009

  92. Farvin KHS, Holdt SL, Jacobsen C (2010) Phenolic composition and in vitro antioxidant activities of selected species of seaweeds from Danish coast. 101st American Oil Chemists Society Annual Meeting and Expo, Phoenix, Arizona. May 16–19

  93. Faulkner DJ (2001) Marine natural products. Nat Prod Rep 18:1–49

    PubMed  CAS  Article  Google Scholar 

  94. Fernandez LE, Valiente OG, Mainardi V, Bello JL, Velez H, Rosado A (1989) Isolation and characterization of an antitumor active agar-type polysaccharide of Gracilaria dominguensis. Carbohydr Res 190:77–83

    PubMed  CAS  Article  Google Scholar 

  95. Fleurence J (1999) Seaweed proteins: biochemical, nutritional aspects and potential uses. Trends Food Sci Technol 10:25–28

    CAS  Article  Google Scholar 

  96. Fleurence J (2004) Seaweed proteins. In: Yada RY (ed) Proteins in food processing. Woodhead Publishing, Cambridge, pp 197–213

    Google Scholar 

  97. Fleurence J, LeCoeur C, Mabeau S, Maurice M, Landrein A (1995) Comparison of different extractive procedures for proteins from the edible seaweeds Ulva rigida and Ulva rotundata. J Appl Phycol 7:577–582

    CAS  Article  Google Scholar 

  98. Fleury N, Lahaye M (1991) Chemical and physicochemical characterization of fibers from Laminaria digitata (Kombu Breton)—a physiological approach. J Sci Food Agric 55:389–400

    CAS  Article  Google Scholar 

  99. Flodin C, Helidoniotis F, Whitfield FB (1999) Seasonal variation in bromophenol content and bromoperoxidase activity in Ulva lactuca. Phytochemistry 51:135–138

    CAS  Article  Google Scholar 

  100. Foster GG, Hodgson AN (1998) Consumption and apparent dry matter digestibility of six intertidal macroalgae by Turbo sarmaticus (Mollusca: Vetigastropoda: Turbinidae). Aquaculture 167:211–227

    Article  Google Scholar 

  101. Foti MC (2007) Antioxidant properties of phenols. J Pharm Pharmacol 59:1673–1685

    PubMed  CAS  Article  Google Scholar 

  102. Francesconi KA, Edmonds JS (1996) Arsenic and marine organisms. Adv Inorg Chem 44:147–189

    Article  Google Scholar 

  103. Freile-Pelegrín Y, Morales JL (2004) Antibacterial activity in marine algae from the coast of Yucatan, Mexico. Bot Mar 47:140–146

    Article  Google Scholar 

  104. Freile-Pelegrín Y, Robledo D (1997) Effects of season on the agar content and chemical characteristics of Gracilaria cornea from Yucatan, Mexico. Bot Mar 40:285–290

    Article  Google Scholar 

  105. FSAI (2010) http://www.fsai.ie/legislation/food_legislation/novel_foods/application_procedure.html, accessed July 2010

  106. Fujiwara-Arasaki T, Mino N, Kuroda M (1984) The protein value in human nutrition of edible marine algae in Japan. Hydrobiologia 116/117:513–516

    Article  Google Scholar 

  107. Fuller RW, Cardellina JH, Kato Y, Brinen LS, Clardy J, Snader KM, Boyd MR (1992) A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines. J Med Chem 35:3007–3011

    PubMed  CAS  Article  Google Scholar 

  108. Funahashi H, Imai T, Tanaka Y, Tsukamura K, Hayakawa Y, Kikumori T, Mase T, Itoh T, Nishikawa M, Hayashi H et al (1999) Wakame seaweed suppresses the proliferation of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. Jpn J Cancer Res 90:922–927

    PubMed  CAS  Google Scholar 

  109. Funahashi H, Imai T, Mase T, Sekiya M, Yokoi K, Hayashi H, Shibata A, Hayashi T, Nishikawa M, Suda N et al (2001) Seaweed prevents breast cancer? Jpn J Cancer Res 92:483–487

    PubMed  CAS  Google Scholar 

  110. Gahan DA, Lynch MB, Callan JJ, O’Sullivan JT, O’Doherty JV (2009) Performance of weanling piglets offered low-, medium- or high-lactose diets supplemented with a seaweed extract from Laminaria spp. Animal 3:24–31

    CAS  Article  Google Scholar 

  111. Galland-Irmouli AV, Fleurence J, Lamghari R, Luçon M, Rouxel C, Barbaroux O, Bronowicki JP, Villaume C, Guéant JL (1999) Nutritional value of proteins from edible seaweed Palmaria palmata (dulse). J Nutr Biochem 10:353–359

    PubMed  CAS  Article  Google Scholar 

  112. Ganesan P, Kumar CS, Bhaskar N (2008) Antioxidant properties of methanol extract and its solvent fractions obtained from selected Indian red seaweeds. Bioresour Technol 99:2717–2723

    PubMed  CAS  Article  Google Scholar 

  113. Garbisa S, Sartor L, Biggin S, Salvato B, Benelli R, Albini A (2001) Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate. Cancer 91:822–832

    PubMed  CAS  Article  Google Scholar 

  114. Gardiner GE, Campbell AJ, O’Doherty JV, Pierce E, Lynch PB, Leonard FC, Stanton C, Ross RP, Lawlor PG (2008) Effect of Ascophyllum nodosum extract on growth performance, digestibility, carcass characteristics and selected intestinal microflora populations of grower-finisher pigs. Anim Feed Sci Technol 141:259–273

    Article  Google Scholar 

  115. Geiszinger A, Goessler W, Pedersen SN, Francesconi KA (2001) Arsenic biotransformation by the brown macroalga Fucus serratus. Environ Toxicol Chem 20:2255–2262

    PubMed  CAS  Google Scholar 

  116. Gessner F (1971) Wasserpermeabilität und Photosynthese bei marinen Algen. Bot Mar 14:29–31

    CAS  Article  Google Scholar 

  117. Ghosh T, Chattopadhyay K, Marschall M, Karmakar P, Mandal P, Ray B (2009) Focus on antivirally active sulfated polysaccharides: from structure–activity analysis to clinical evaluation. Glycobiology 19:2–15

    PubMed  CAS  Article  Google Scholar 

  118. Ginzberg A, Cohen M, Sod-Moriah UA, Shany S, Rosenshtrauch A, Arad S (2000) Chickens fed with biomass of the red microalga Porphyridium sp. have reduced blood cholesterol level and modified fatty acid composition in egg yolk. J Appl Phycol 12:325–330

    Article  Google Scholar 

  119. Glyantsev S, Annaev A, Savvina TV (1993) Morphological basis for selecting composition and structure of biologically active compounds based on sodium alginate for wound treatment. Byull Eksp Biol Med 115:65–67

    Article  Google Scholar 

  120. Goemar (2010) http://www.goemar.fr, accessed 5 June 2010

  121. Granert C, Raud J, Waage A, Lindquist L (1999) Effects of polysaccharide fucoidin on cerebrospinal fluid interleukin-1 and tumor necrosis factor alpha in pneumococcal meningitis in the rabbit. Infect Immun 67:2071–2074

    PubMed  CAS  Google Scholar 

  122. Gravett RB (2000) The effect of Ascophyllum nodosum on immune function, performance, and carcass characteristics of sheep and cattle. Master’s thesis, Graduate Faculty of Texas Tech University, pp 1–86

  123. Greger M, Malm T, Kautsky L (2007) Heavy metal transfer from composted macroalgae to crops. Eur J Agron 26:257–265

    CAS  Article  Google Scholar 

  124. Gruenwald J (2008) http://www.entrepreneur.com/tradejournals/article/189971352.html, accessed 8 January 2010

  125. Hammerstrom K, Dethier MN, Duggins DO (1998) Rapid phlorotannin induction and relaxation in five Washington kelps. Mar Ecol Prog Ser 165:263–305

    Article  Google Scholar 

  126. Han JG, Syed AQ, Kwon M, Ha JH, Lee HY (2008) Antioxident, immunomodulatory and anticancer activity of fucoidan isolated from Fucus vesiculosus. J Biotechnol 136:571

    Article  Google Scholar 

  127. Haug A, Jensen A (1954) Seasonal variation in the chemical composition of Alaria esculenta, Laminaria saccharina, Laminaria hyperborea and Laminaria digitata from Northern Norway, Norwegian Institute of Seaweed Research. Akademisk Trykningssentral, Blindern, Norway. Report 4, pp 1–14

  128. Haug A, Larsen B (1957) Carotene content of seaweed and seaweed meal. Norwegian Institute of Seaweed Research. Akademisk Trykningssentral, Blindern, Norway. Report 16, pp 1–19

  129. Haug A, Larsen B (1958) Brunfarging av tangmel og tangekstrakter [The formation of brown coloured substances in seaweed and seaweed extracts]. Norwegian Institute of Seaweed Research. NTH Trykk, Norway. Report 22, pp 1–18

  130. Haugan JA, Liaaen-Jensen S (1989) Algal carotenoids.43. Improved isolation procedure for fucoxanthin. Phytochemistry 28:2797–2798

    CAS  Article  Google Scholar 

  131. Haugan JA, Liaaen-Jensen S (1994) Algal carotenoids.54. Carotenoids of brown-algae (Phaeophyceae). Biochem Syst Ecol 22:31–41

    CAS  Article  Google Scholar 

  132. Hawkins WW, Leonard VG (1963) Antithrombic activity of carrageenan in human blood. Can J Physiol Biochem 41:1325–1327

    CAS  Article  Google Scholar 

  133. Hawkins WW, Yaphe W (1965) Carrageenan as a dietary constituent for rat—faecal excretion nitrogen absorption and growth. Can J Biochem 43:479–484

    PubMed  CAS  Google Scholar 

  134. Hawkins WW, Leonard VG, Maxwell JE, Rastogi KS (1962) A study of the prolonged intake of small amounts of EDTA on the utilization of low dietary levels of calcium and iron by the rat. Can J Physiol Biochem 40:391

    CAS  Article  Google Scholar 

  135. Hayashi L, Yokoya NS, Ostini S, Pereira RTL, Braga ES, Oliveira EC (2008) Nutrients removed by Kappaphycus alvarezii (Rhodophyta, Solieriaceae) in integrated cultivation with fishes in re-circulating water. Aquaculture 277:185–191

    CAS  Article  Google Scholar 

  136. Heller L (2009) Functional foods: what they mean around the world. http://www.nutraingredients-usa.com/Industry/Functional-foods-What-they-mean-around-the-world, accessed July 2010

  137. Hellio C, De La Broise D, Dufosse L, Le Gal Y, Bourgougnon N (2001) Inhibition of marine bacteria by extracts of macroalgae: potential use for environmentally friendly antifouling paints. Mar Environ Res 52:231–247

    PubMed  CAS  Article  Google Scholar 

  138. Hemmingson J, Falshaw R, Furneaux R, Thompson K (2006) Structure and antiviral activity of the galactofucan sulfates extracted from Undaria pinnatifida (Phaeophyta). J Appl Phycol 18:185–193

    CAS  Article  Google Scholar 

  139. Hennequart F (2007) Seaweed applications in human health/nutrition: the example of algal extracts as functional ingredients in novel beverages. 4th International Symposium Health and Sea, Granville, France. http://www.sante-mer.com/pdf_dwnld/O17_Presentation_H_HENNEQUART.pdf, accessed 26 October 2010

  140. Heo SJ, Jeon YJ (2009) Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage. J Photochem Photobiol B 65:101–107

    Article  CAS  Google Scholar 

  141. Heo SJ, Park EJ, Lee KW, Jeon YJ (2005) Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresour Technol 96:1613–1623

    PubMed  CAS  Article  Google Scholar 

  142. Herbreteau F, Coiffard LJM, Derrien A, De Roeck-Holtzhauer Y (1997) The fatty acid composition of five species of macroalgae. Bot Mar 40:25–27

    CAS  Article  Google Scholar 

  143. Hoebler C, Guillon F, Darcy-Vrillon B, Vaugelade P, Lahaye M, Worthington E, Duee PH, Barry JL (2000) Supplementation of pig diet with algal fibre changes the chemical and physicochemical characteristics of digesta. J Sci Food Agric 80:1357–1364

    CAS  Article  Google Scholar 

  144. Hoffmane R, Paper DH, Donaldson J, Alban S, Franz G (1995) Characterization of a laminarin sulfate which inhibits basic fibroblast growth-factor binding and endothelial-cell proliferation. J Cell Sci 108:3591–3598

    Google Scholar 

  145. Holdt SL (2009) Nutrient reduction in aquaculture waste by macroalgae production. PhD dissertation, University of Southern Denmark, 80 pp

  146. Hori K, Ikegami S, Miyazawa K, Ito K (1988) Mitogenic and antineoplastic isoagglutinins from the red alga Solieria robusta. Phytochemistry 27:2063–2067

    CAS  Article  Google Scholar 

  147. Hori K, Matsubara K, Miyazawa K (2000) Primary structures of two hemagglutinins from the marine red alga, Hypnea japonica. Biochim Biophys Acta Gen Subj 147:226–236

    Article  Google Scholar 

  148. Hori K, Sato Y, Ito K, Fujiwara Y, Iwamoto Y, Makino H, Kawakubo A (2007) Strict specificity for high-mannose type N-glycans and primary structure of a red alga Eucheuma serra lectin. Glycobiology 17:479–491

    PubMed  CAS  Article  Google Scholar 

  149. Horn SJ (2000) Bioenergy from brown seaweeds. PhD dissertation, Department of Biotechnology, Norwegian University of Science and Technology, NTNU, Norway, 82 pp

  150. Hosokawa M, Wanezaki S, Miyauchi K, Kunihara H, Kohno H, Kawabata J, Odashima S, Takahashi K (1999) Apoptosis-inducing effect of fucoxanthin on human leukemia cell line HIL-60. Food Sci Technol Res 5:243–246

    CAS  Article  Google Scholar 

  151. Houghton JD (1996) Haems and bilins. In: Houghton JD, Hendry GAF (eds) Natural food colorants, 2nd edn. Blackie (Chapman and Hall), Glasgow, pp 157–196

    Google Scholar 

  152. Houston MC (2005) Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension. Prog Cardiovasc Dis 47:396–449

    PubMed  CAS  Article  Google Scholar 

  153. Hu JF, Geng MY, Zhang JT, Jiang HD (2001) An in vitro study of the structure–activity relationships of sulfated polysaccharide from brown algae to its antioxidant effect. J Asian Nat Prod Res 3:353–358

    PubMed  CAS  Article  Google Scholar 

  154. Huang HL, Wang BG (2004) Antioxidant capacity and lipophilic content of seaweeds collected from the Qingdao coastline. J Agric Food Chem 52:4993–4997

    PubMed  CAS  Article  Google Scholar 

  155. Ichikawa S, Kamoshida M, Hanaoka K, Hamano M, Maitani T, Kaise T (2006) Decrease of arsenic in edible brown algae Hijikia fusiforme by the cooking process. Appl Organomet Chem 20:585–590

    CAS  Article  Google Scholar 

  156. Ikeda K, Kitamura A, Machida H, Watanabe M, Negishi H, Hiraoka J, Nakano T (2003) Effect of Undaria pinnatifida (wakame) on the development of cerebrovascular diseases in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 30:44–48

    PubMed  CAS  Article  Google Scholar 

  157. Iliopoulou D, Roussis V, Pannecouque C, De Clercq E, Vagias C (2002) Halogenated sesquiterpenes from the red alga Laurencia obtusa. Tetrahedron 58:6749–6755

    CAS  Article  Google Scholar 

  158. Indergaard M, Minsaas J (1991) Seaweed resources in Europe: uses and potential. In: Guiry MD, Blunden G (eds) Animal and human nutrition. Wiley, Chichester, pp 21–64

    Google Scholar 

  159. Iqbal M, Flick-Smith H, McCauley JW (2000) Interactions of bovine viral diarrhoea virus glycoprotein E-rns with cell surface glycosaminoglycans. J Gen Virol 81:451–459

    PubMed  CAS  Google Scholar 

  160. Ishihara K, Murata M, Kaneniwa M, Saito H, Shinohara K, Maeda-Yamamoto M (1998) Inhibition of icosanoid production in MC/9 mouse mast cells by n-3 polyunsaturated fatty acids isolated from edible marine algae. Biosci Biotechnol Biochem 62:1412–1415

    PubMed  CAS  Article  Google Scholar 

  161. Ishihara K, Murata M, Kaneniwa M, Saito H, Komatsu W, Shinohara K (2000) Purification of stearidonic acid (18: 4(n-3)) and hexadecatetraenoic acid (16: 4(n-3)) from algal fatty acid with lipase and medium pressure liquid chromatography. Biosci Biotechnol Biochem 64:2454–2457

    PubMed  CAS  Article  Google Scholar 

  162. Ito K, Tsuchida Y (1972) The effect of algal polysaccharides on depressing of plasma cholesterol level in rats. Proceedings of the7th International Seaweed Symposium, pp 451–455

  163. Je J-Y, Park PJ, Kim EK, Park JS, Yoon HD, Kim KR, Ahn CB (2009) Antioxidant activity of enzymatic extracts from the brown seaweed Undaria pinnatifida by electron spin resonance spectroscopy. LWT Food Sci Technol 42:874–878

    CAS  Article  Google Scholar 

  164. Jenkins DJA, Wolever TMS, Leeds AR, Gassull MA, Haisman P, Dilawari J, Goff DV, Metz GL, Alberti KGMM (1978) Dietary fibers, fiber analogs, and glucose-tolerance—importance of viscosity. Br Med J 1:1392–1394

    PubMed  CAS  Article  Google Scholar 

  165. Jensen A (1956) Component sugars of some common brown algae. Norwegian Institute of Seaweed Research, Akademisk Trykningssentral, Blindern, Oslo. Report 9, pp 1–8

  166. Jensen A (1960) Produksjon av tangmel. Norwegian Institute of Seaweed Research, N.T.H. TRYKK. Report 24, pp 1–23

  167. Jensen A (1966) Carotenoids of Norwegian brown seaweeds and of seaweed meals. Norwegian Institute of Seaweed Research, TAPIR. Report 31, pp 1–138

  168. Jensen A (1969a) Tocopherol content of seaweed and seaweed meal. 2. Individual, diurnal and seasonal variations in some Fucaceae. J Sci Food Agric 20:454–458

    CAS  Article  Google Scholar 

  169. Jensen A (1969b) Tocopherol content of seaweed and seaweed meal. 3. Influence of processing and storage on content of tocopherols, carotenoids and ascorbic acid in seawood meal. J Sci Food Agric 20:622–626

    PubMed  CAS  Article  Google Scholar 

  170. Jensen A, Haug A (1956) Geographical and seasonal variation in the chemical composition of Laminaria hyperborea and Laminaria digitata from the Norwegian coast. Norwegian Institute of Seaweed Research, Akademisk Trykningssentral, Blindern, Oslo. Report 14, pp 1–8

  171. Jensen A, Nebb H, Sæter EA (1968) The value of Norwegian seaweed meal as a mineral supplement for dairy cows. Norwegian Institute of Seaweed Research, TAPIR. Report 32, pp 1–35

  172. Jeon Y-J, Athukorala Y, Lee J (2005) Characterization of agarose product from agar using DMSO. Algae 20:61–67

    Article  Google Scholar 

  173. Johnson CR, Mann KH (1986) The importance of plant defence abilities to the structure of subtidal seaweed communities: the kelp Laminaria longicruris de la Pylaie survives grazing by the snail Lacuna vincta (Montagu) at high population densities. J Exp Mar Biol Ecol 97:231–267

    Article  Google Scholar 

  174. Jones AL, Harwood JL (1992) Lipid composition of the brown algae Fucus vesiculosus and Ascophyllum nodosum. Phytochemistry 31:3397–3403

    CAS  Article  Google Scholar 

  175. Joseph J, Niggemann B, Zaenker KS, Entschladen F (2002) The neurotransmitter γ-aminobutyric acid is an inhibitory regulator for the migration of SW 480 colon carcinoma cells. Cancer Res 62:6467–6469

    PubMed  CAS  Google Scholar 

  176. Kaeffer B, Benard C, Lahaye M, Blottiere HM, Cherbut C (1999) Biological properties of ulvan, a new source of green seaweed sulfated polysaccharides, on cultured normal and cancerous colonic epithelial tells. Planta Med 65:527–531

    PubMed  CAS  Article  Google Scholar 

  177. Kalt W, McDonald JE, Donner H (2000) Anthocyanins, phenolics, and antioxidant capacity of processed lowbush blueberry products. J Food Sci 65:390–393

    CAS  Article  Google Scholar 

  178. Kanazawa K, Ozaki Y, Hashimoto T, Das SK, Matsushita S, Hirano M, Okada T, Komoto A, Mori N, Nakatsuka M (2008) Commercial-scale preparation of biofunctional fucoxanthin from waste parts of brown sea algae Laminalia japonica. Food Sci Technol Res 14:573–582

    CAS  Article  Google Scholar 

  179. Kang K, Park Y, Hwang HJ, Kim SH, Lee JG, Shin HC (2003) Antioxidative properties of brown algae polyphenolics and their perspectives as chemopreventive agents against vascular risk factors. Arch Pharm Res 26:286–293

    PubMed  CAS  Article  Google Scholar 

  180. Katayama S, Ohshita J, Sugaya K, Hirano M, Momose Y, Yamamura S (1998) New medicinal treatment for severe gingivostomatitis. Int J Mol Med 2:675–679

    PubMed  CAS  Google Scholar 

  181. Kawakubo AL, Makino H, Ohnishi J, Hirohara H, Hori K (1997) The marine red alga Eucheuma serra J. Agardh, a high yielding source of two isolectins. J Appl Phycol 9:331–338

    CAS  Article  Google Scholar 

  182. Kawakubo A, Makino H, Ohnishi J, Hirohara H, Hori K (1999) Occurrence of highly yielded lectins homologous within the genus Eucheuma. J Appl Phycol 11:149–156

    Article  Google Scholar 

  183. Khan MNA, Cho JY, Lee MC, Kang JY, Park NG, Fujii H, Hong YK (2007) Isolation of two anti-inflammatory and one pro-inflammatory polyunsaturated fatty acids from the brown seaweed Undaria pinnatifida. J Agric Food Chem 55:6984–6988

    PubMed  CAS  Article  Google Scholar 

  184. Khan MNA, Suk-Choi J, Lee MC, Kim E, Nam TJ, Fujii H, Hong YK (2008) Anti-inflammatory activities of methanol extracts from various seaweed species. J Environ Biol 29:465–469

    PubMed  Google Scholar 

  185. Khotimchenko SV (1991) Fatty-acid composition of 7 Sargassum species. Phytochemistry 30:2639–2641

    CAS  Article  Google Scholar 

  186. Khotimchenko SV (2003) The fatty acid composition of glycolipids of marine macrophytes. Russ J Mar Biol 29:126–128

    CAS  Article  Google Scholar 

  187. Khotimchenko SV (2005) Lipids from the marine alga Gracilaria verrucosa. Chem Nat Compd 41:285–288

    CAS  Article  Google Scholar 

  188. Khotimchenko SV, Levchenko EV (1997) Lipids of the red alga Gracilaria verrucosa (Huds.) Papenf. Bot Mar 40:541–545

    CAS  Article  Google Scholar 

  189. Khotimchenko YS, Kovalev VV, Savchenko OV, Ziganshina OA (2001) Physical–chemical properties, physiological activity, and usage of alginates, the polysaccharides of brown algae. Russ J Mar Biol 27:53–64

    Article  Google Scholar 

  190. Kim IH, Lee JH (2008) Antimicrobial activities against methicillin-resistant Staphylococcus aureus from macroalgae. J Ind Eng Chem 14:568–572

    CAS  Google Scholar 

  191. Kim MK, JP D, Thomas JC, Giraud G (1996) Seasonal variations of triacylglycerols and fatty acids in Fucus serratus. Phytochemistry 43:49–55

    CAS  Article  Google Scholar 

  192. Kimura Y, Watanabe K, Okuda H (1996) Effects of soluble sodium alginate on cholesterol excretion and glucose tolerance in rats. J Ethnopharmacol 54:47–54

    PubMed  CAS  Article  Google Scholar 

  193. Kindness G, Williamson FB, Long WF (1979) Effect of polyanetholesulphonic acid and xylan sulphate on antithrombin III activity. Biochem Biophys Res Commun 13:1062–1068

    Article  Google Scholar 

  194. Kiriyama S, Okazaki Y, Yoshida A (1969) Hypocholesterolemic effect of polysaccharides and polysaccharide-rich foodstuffs in cholesterol-fed rats. J Nutr 97:382–388

    PubMed  CAS  Google Scholar 

  195. Klinkenberg-Knol EC, Festen HP, Meuwissen SG (1995) Pharmacological management of gastro-oesophageal reflux disease. Drugs 49:495–710

    Article  Google Scholar 

  196. Knott MG, Mkwananzi H, Arendse CE, Hendricks DT, Bolton JJ, Beukes DR (2005) Plocoralides A-C, polyhalogenated monoterpenes from the marine alga Plocamium corallorhiza. Phytochemistry 66:1108–1112

    PubMed  CAS  Article  Google Scholar 

  197. Korver O, Kühn MC, Richardson DP (2008) The functional food dossier; Building solid health claims. Practical industrial guide. Foodlink Forum, Bennekom, the Netherlands, 185 pp

  198. Kotake-Nara E, Kushiro M, Zhang H, Sugawara T, Miyashita K, Nagao A (2001) Carotenoids affect proliferation of human prostate cancer cells. J Nutr 131:3303–3306

    PubMed  CAS  Google Scholar 

  199. Kumar CS, Ganesan P, Bhaskar N (2008a) In vitro antioxidant activities of three selected brown seaweeds of India. Food Chem 107:707–713

    Article  CAS  Google Scholar 

  200. Kumar CS, Ganesan P, Suresh PV, Bhaskar N (2008b) Seaweeds as a source of nutritionally beneficial compounds—a review. J Food Sci Technol 45:1–13

    CAS  Google Scholar 

  201. Kumar KS, Ganesane K, Rao PVS (2008c) Antioxidant potential of solvent extracts of Kappaphycus alvarezii (Doty) Doty—an edible seaweed. Food Chem 107:289–295

    CAS  Article  Google Scholar 

  202. Kuznetsova TA, Krylova NV, Besednova NN, Vasiléva VN, Zviagintseva TN, Krashevskii SV, Eliakova LA (1994) The effect of translam on the natural resistance indices of the irradiated organism. Radiats Biol Radioecol 34:236–239

    PubMed  CAS  Google Scholar 

  203. Kylin H (1913) Zur Biochemie der Meeresalgen. Hoppe-Seyler’s Z Physiol Chem 83:171–197

    CAS  Article  Google Scholar 

  204. Lahaye M (1991) Marine-algae as sources of fibers—determination of soluble and insoluble dietary fiber contents in some sea vegetables. J Sci Food Agric 54:587–594

    CAS  Article  Google Scholar 

  205. Lahaye M (1998) NMR spectroscopic characterisation of oligosaccharides from two Ulva rigida ulvan samples (Ulvales, Chlorophyta) degraded by a lyase. Carbohydr Res 314:1–12

    PubMed  CAS  Article  Google Scholar 

  206. Lahaye M, Kaeffer B (1997) Seaweed dietary fibres: structure, physico-chemical and biological properties relevant to intestinal physiology. Sci Aliment 17:563–584

    CAS  Google Scholar 

  207. Lahaye M, Ray B (1996) Cell-wall polysaccharides from the marine green alga Ulva rigida (Ulvales, Chlorophyta)—NMR analysis of ulvan oligosaccharides. Carbohydr Res 283:161–173

    PubMed  CAS  Article  Google Scholar 

  208. Lahaye M, Robic A (2007) Structure and functional properties of ulvan, a polysaccharide from green seaweeds. Biomacromolecules 8:1765–1774

    PubMed  CAS  Article  Google Scholar 

  209. Lahaye M, Michel C, Barry JL (1993) Chemical, physicochemical and in vitro fermentation characteristics of dietary-fibers from Palmaria palmata (L.) Kuntze. Food Chem 47:29–36

    CAS  Article  Google Scholar 

  210. Lahaye M, Inizan F, Vigouroux J (1998) NMR analysis of the chemical structure of ulvan and of ulvan–boron complex formation. Carbohydr Polym 36:239–249

    CAS  Article  Google Scholar 

  211. Lahaye M, Rondeau-Mouro C, Deniaud E, Buleon A (2003) Solid-state 13C NMR spectroscopy studies of xylans in the cell wall of Palmaria palmata (L. Kuntze, Rhodophyta). Carbohydr Res 338:1559–1569

    PubMed  CAS  Article  Google Scholar 

  212. Lam C, Stang A, Harder T (2008) Planktonic bacteria and fungi are selectively eliminated by exposure to marine macroalgae in close proximity. FEMS Microbiol Ecol 63:283–291

    PubMed  CAS  Article  Google Scholar 

  213. Lamare MD, Wing SR (2001) Calorific content of New Zealand marine macrophytes. NZ J Mar Freshwat Res 35:335–341

    Article  Google Scholar 

  214. Lamela M, Anca J, Villar R, Otero J, Calleja JM (1989) Hypoglycemic activity of several seaweed extracts. J Ethnopharmacol 27:35–43

    PubMed  CAS  Article  Google Scholar 

  215. Larsen B, Haug A (1958) The influence of habitat on the chemical composition of Ascophyllum nodosum (L.) Le Jol.-reprint of report 20. Norwegian Institute of Seaweed Research. Trondheim, Norway, pp 29–38

  216. Lasky LA (1995) Selectin–carbohydrate interactions and the initiation of the inflammatory response. Annu Rev Biochem 64:113–139

    PubMed  CAS  Article  Google Scholar 

  217. Le Tutour B (1990) Antioxidative activities of algal extracts, synergistic effect with vitamin E. Phytochemistry 29:3759–3765

    Article  Google Scholar 

  218. Le Tutour B, Benslimane F, MPe G, Saadan B, Quemeneur F (1998) Antioxidant and pro-oxidant activities of the brown algae, Laminaria digitata, Himanthalia elongata, Fucus vesiculosus, Fucus serratus and Ascophyllum nodosum. J Appl Phycol 10:121–129

    Article  Google Scholar 

  219. Lee JB, Hayashi K, Hashimoto M, Nakano T, Hayashi T (2004) Novel antiviral fucoidan from sporophyll of Undaria pinnatifida (Mekabu). Chem Pharm Bull 52:1091–1094

    PubMed  CAS  Article  Google Scholar 

  220. Li F, Tian TC, Shi YC (1995) Study on anti virus effect of fucoidan in vitro. J Norman Bethune Univ Med Sci 21:255–257

    CAS  Google Scholar 

  221. Li N, Zhang QB, Song JM (2005) Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats. Food Chem Toxicol 43:421–426

    PubMed  Article  CAS  Google Scholar 

  222. Li K, Li XM, Ji NY, Wang BG (2007) Natural bromophenols from the marine red alga Polysiphonia urceolata (Rhodomelaceae): structural elucidation and DPPH radical-scavenging activity. Bioorg Med Chem 15:6627–6631

    PubMed  CAS  Article  Google Scholar 

  223. Li B, Lu F, Wei XJ, Zhao RX (2008a) Fucoidan: structure and bioactivity. Molecules 13:1671–1695

    CAS  Article  Google Scholar 

  224. Li Y, Qian ZJ, Le QT, Kim MM, Kim SK (2008b) Bioactive phloroglucinol derivatives isolated from an edible marine brown alga, Ecklonia cava. J Biotechnol 136:578

    Article  Google Scholar 

  225. Li Y, Qian ZJ, Ryu B, Lee SH, Kim MM, Kim SK (2009) Chemical components and its antioxidant properties in vitro: an edible marine brown alga, Ecklonia cava. Bioorg Med Chem 17:1963–1973

    PubMed  CAS  Article  Google Scholar 

  226. Liao WR, Lin JY, Shieh WY, Jeng WL, Huang R (2003) Antibiotic activity of lectins from marine algae against marine vibrios. J Ind Microbiol Biotechnol 30:433–439

    PubMed  CAS  Article  Google Scholar 

  227. Lim SN, Cheung PCK, Ooi VEC, Ang PO (2002) Evaluation of antioxidative activity of extracts from a brown seaweed, Sargassum siliquastrum. J Agric Food Chem 50:3862–3866

    PubMed  CAS  Article  Google Scholar 

  228. Liu RM, Bignon J, Haroun-Bouhedja F, Bittoun P, Vassy J, Fermandjian S, Wdzieczak-Bakala J, Boisson-Vidal C (2005) Inhibitory effect of fucoidan on the adhesion of adenocarcinoma cells to fibronectin. Anticancer Res 25:2129–2133

    PubMed  CAS  Google Scholar 

  229. Lobban CS, Harrison PJ (1994) Seaweed ecology and physiology. Cambridge University Press, Cambridge, 384 pp

    Google Scholar 

  230. Lourenço R, Camilo ME (2002) Taurine: a conditionally essential amino acid in humans? An overview in health and disease. Nutr Hosp 17:262–270

    PubMed  Google Scholar 

  231. Lüder UH, Clayton MN (2004) Induction of phlorotannins in the brown macroalga Ecklonia radiata (Laminariales, Phaeophyta) in response to simulated herbivory—the first microscopic study. Planta 218:928–937

    PubMed  Article  CAS  Google Scholar 

  232. Lüning (2008) Integrated macroalgae-oyster aquaculture on a north sea island: seasonal productivity of the brown alga Laminaria saccharina and the red algae Palmaria palmata; Solieria chordalis, Gracilaria vermiculophylla, and the use of these seaweeds in human nutrition or as raw material for the cosmetics industry. 11th International Conference on Applied Phycology, Galway, Ireland. June 22–27

  233. Luescher-Mattli M (2003) Algae, a possible source for new drugs in the treatment of HIV and other viral diseases. Curr Med Chem 2:219–225

    CAS  Google Scholar 

  234. Mabeau S, Fleurence J (1993) Seaweed in food products: biochemical and nutritional aspects. Trends Food Sci Technol 4:103–107

    CAS  Article  Google Scholar 

  235. MacArtain P, Gill CIR, Brooks M, Campbell R, Rowland IR (2007) Nutritional value of edible seaweeds. Nutr Rev 65:535–543

    PubMed  Article  Google Scholar 

  236. Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K (2005) Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun 332:392–397

    PubMed  CAS  Article  Google Scholar 

  237. Maeda H, Tsukui T, Sashima T, Hosokawa M, Miyashita K (2008a) Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient. Asia Pac J Clin Nutr 17:196–199

    PubMed  CAS  Google Scholar 

  238. Maeda H, Hosokawa M, Sashima T, Miyashita K (2008b) Antiobesity effect of fucoxanthin from edible seaweeds and its multibiological functions. ACS Symp Ser 993:376–388

    CAS  Article  Google Scholar 

  239. Mai K, Mercer JP, Donlon J (1994) Comparative studies on the nutrition of two species of abalone, Haliotis tuberculata L. and Haliotis discus Hannai Ino. II. Amino acid composition of abalone and six species of macroalgae with an assessment of their nutritional-value. Aquaculture 128:115–130

    CAS  Article  Google Scholar 

  240. Maliakal PP, Coville PF, Wanwimolruk S (2001) Tea consumption modulates hepatic drug metabolizing enzymes in Wistar rats. J Pharm Pharmacol 53:569–577

    PubMed  CAS  Article  Google Scholar 

  241. Mandal P, Mateu CG, Chattopadhyay K, Pujol CA, Damonte EB, Ray B (2007) Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica. Antiviral Chem Chemother 18:153–162

    CAS  Google Scholar 

  242. Marais MF, Joseleau JP (2001) A fucoidan fraction from Ascophyllum nodosum. Carbohydr Res 336:155–159

    PubMed  CAS  Article  Google Scholar 

  243. Marinho-Soriano E, Fonseca PC, Carneiro MAA, Moreira WSC (2006) Seasonal variation in the chemical composition of two tropical seaweeds. Bioresour Technol 97:2402–2406

    PubMed  CAS  Article  Google Scholar 

  244. Marinova (2010) Nutraceuticals from Maritech extracts. http://www.marinova.com.au/Nutraceuticals.html on December 13 2010

  245. Marsham S, Scott GW, Tobin ML (2007) Comparison of nutritive chemistry of a range of temperate seaweeds. Food Chem 100:1331–1336

    CAS  Article  Google Scholar 

  246. Martino AD, Douady D, Quinet-Szely M, Rousseau B, Crépineau F, Apt K, Caron L (2004) The light-harvesting antenna of brown algae. Highly homologous proteins encoded by a multigene family. Eur J Biochem 267:5540–5549

    Article  Google Scholar 

  247. Maruyama H, Tamauchi H, Hashimoto M, Nakano T (2003) Antitumor activity and immune response of Mekabu fucoidan extracted from sporophyll of Undaria pinnatifida. In Vivo 17:245–249

    PubMed  CAS  Google Scholar 

  248. Maruyama H, Tamauchi H, Iizuka M, Nakano T (2006) The role of NK cells in antitumor activity of dietary fucoidan from Undoria pinnotifida sporophylls (Mekabu). Planta Med 72:1415–1417

    PubMed  CAS  Article  Google Scholar 

  249. Maruyama H, Tanaka M, Hashimoto M, Inoue M, Sasahara T (2007) The suppressive effect of Mekabu fucoidan on an attachment of Cryptosporidium parvum oocysts to the intestinal epithelial cells in neonatal mice. Life Sci 80:775–781

    PubMed  CAS  Article  Google Scholar 

  250. Matsubara K, Sumi H, Hori K (1996) Platelet aggregation is inhibited by phycolectins. Experientia 52:540–543

    PubMed  CAS  Article  Google Scholar 

  251. Matsubara K, Xue C, Zhao X, Mori M, Sugawara T, Hirata T (2005) Effects of middle molecular weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells. Int J Mol Med 15:695–699

    PubMed  CAS  Google Scholar 

  252. Mayer AMS, Hamann MT (2004) Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action. Mar Biotechnol 6:37–52

    PubMed  CAS  Article  Google Scholar 

  253. Mayer AMS, Rodríguez AD, Berlinck RGS, Hamann MT (2007) Marine pharmacology in 2003–4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. Comp Biochem Physiol C 145:553–581

    Google Scholar 

  254. McHugh DJ (1987) Production and utilization of products from commercial seaweeds. FAO Fisheries Technical Paper No. 288, pp 1–189

  255. McHugh DJ (2003) A guide to the seaweed industry. FAO Fish Tech Pap 441, Rome, Italy, 105 pp

  256. Mehta SK, Gaur JP (2005) Use of algae for removing heavy metal ions from wastewater: progress and prospects. Crit Rev Biotechnol 25:113–152

    PubMed  CAS  Article  Google Scholar 

  257. Miao HQ, Elkin M, Aingorn E, Ishai-Michaeli R, Stein CA, Vlodavsky I (1999) Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides. Int J Cancer 83:424–431

    PubMed  CAS  Article  Google Scholar 

  258. Michel C, Macfarlane GT (1996) Digestive fates of soluble polysaccharides from marine macroalgae: involvement of the colonic microflora and physiological consequences for the host. J Appl Bacteriol 80:349–369

    PubMed  CAS  Google Scholar 

  259. Michel C, Lahaye M, Bonnet C, Mabeau S, Barry JL (1996) In vitro fermentation by human faecal bacteria of total and purified dietary fibres from brown seaweeds. Br J Nutr 75:263–280

    PubMed  CAS  Article  Google Scholar 

  260. Miki W (1991) Biological functions and activities of animal carotenoids. Pure Appl Chem 63:141–146

    CAS  Article  Google Scholar 

  261. Militante JD, Lombardini JB (2002) Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids 23:381–393

    PubMed  CAS  Article  Google Scholar 

  262. Miraglio AM (2009) Phospholipids: structure plus functionality. http://www foodproductdesign com/articles/2006/03/phospholipids-structure-plus-functionality.aspx, accessed 5 June 2010

  263. Mishra VK, Temelli F, Ooraikul B, Shacklock PF, Craigie JS (1993) Lipids of the red alga, Palmaria palmata. Bot Mar 36:169–174

    CAS  Article  Google Scholar 

  264. Miyashita H, Hosokawa M (2008) Beneficial health effects of seaweed carotenoid, fucoxanthin. In: Barrow C, Shahidi F (eds) Marine nutraceuticals and functional foods. CRC, Boca Raton, pp 297–320

    Google Scholar 

  265. Mochizuki H, Takido J, Oda H, Yokogoshi H (1999) Improving effect of dietary taurine on marked hypercholesterolemia induced by a high-cholesterol diet in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem 63:1984–1987

    PubMed  CAS  Article  Google Scholar 

  266. Morgan K, Wright J, Simpson F (1980) Review of chemical constituents of the red alga Palmaria palmata (dulse). Econ Bot 34:27–50

    CAS  Article  Google Scholar 

  267. Mori J, Matsunaga T, Takahashi S, Hasegawa C, Saito H (2003) Inhibitory activity on lipid peroxidation of extracts from marine brown alga. Phytother Res 17:549–551

    PubMed  Article  Google Scholar 

  268. Mori T, O’Keefe BR, Sowder RC, Bringans S, Gardella R, Berg S, Cochran P, Turpin JA, Buckheit RW, McMahon JB et al (2005) Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. J Biol Chem 280:9345–9353

    PubMed  CAS  Article  Google Scholar 

  269. Morrissey J, Kraan S, Guiry MD (2001) A guide to commercially important seaweeds on the Irish coast. Bord Iascaigh Mhara, Dublin, 66 pp

    Google Scholar 

  270. Morse ANC (1991) GABA-mimetic peptides from marine algae and cyanobacteria as potential diagnostic and therapeutic agents. In: Thompson MF, Sarojini R, Nagabhushanam R (eds) Bioactive compounds from marine organisms. Oxford & IBH Publishing, New Delhi, pp 167–172

    Google Scholar 

  271. Mouradi-Givernaud A, Givernaud T, Morvan H, Cosson J (1992) Agar from Gelidium latifolium (Rhodophyceae, Gelidiales)—biochemical composition and seasonal variations. Bot Mar 35:153–159

    CAS  Article  Google Scholar 

  272. Mouritsen OG (2009) Tang-grøntsager fra havet. Nyt Nordisk Forlag, Arnold Busck, Copenhagen, 284 pp (in Danish)

    Google Scholar 

  273. Munda IM (1977) Differences in amino acid composition of estuarine and marine fucoids. Aquat Bot 3:273–280

    CAS  Article  Google Scholar 

  274. Murata M, Nakazoe J (2001) Production and use of marine algae in Japan. Jpn Agr Res Q 35:281–290

    Google Scholar 

  275. Murata M, Ishihara K, Saito H (1999) Hepatic fatty acid oxidation enzyme activities are stimulated in rats fed the brown seaweed, Undaria pinnatifida (wakame). J Nutr 129:146–151

    PubMed  CAS  Google Scholar 

  276. Murata M, Sano Y, Ishihara K, Uchida M (2002) Dietary fish oil and Undaria pinnatifida (wakame) synergistically decrease rat serum and liver triacylglycerol. J Nutr 132:742–747

    PubMed  CAS  Google Scholar 

  277. Müssig K (2009) Iodine-induced toxic effects due to seaweed consumption. In: Preedy VR, Burrow GN, Watson R (eds) Comprehensive handbook of iodine. Elsevier, New York, pp 897–908

    Google Scholar 

  278. Mustafa MG, Wakamatsu S, Takeda TA, Umino T, Nakagawa H (1995) Effects of algae meal as feed additive on growth, feed efficiency, and body composition in red sea bream. Fish Sci 61:25–28

    CAS  Google Scholar 

  279. Nabors LOB (2004) Alternative sweeteners. Agro Food Industry Hi-Tech 15:39–41

    Google Scholar 

  280. Nagaoka M, Shibata H, Kimura-Takagi I, Hashimoto S, Kimura K, Makino T, Aiyama R, Ueyama S, Yokokura T (1999) Structural study of fucoidan from Cladosiphon okamuranus Tokida. Glycoconj J 16:19–26

    PubMed  CAS  Article  Google Scholar 

  281. Nagaoka M, Shibata H, Kimura I, Hashimoto S (2003) Oligosaccharide derivatives and process for producing the same. United States Patent No. 6,645,940

  282. Nagayama K, Shibata T, Fujimoto K, Honjo T, Nakamura T (2003) Algicidal effect of phlorotannins from the brown alga Ecklonia kurome on red tide microalgae. Aquaculture 218:601–611

    CAS  Article  Google Scholar 

  283. Nakagawa H, Kasahara S (1986) Effect of Ulva meal supplement to diet on the lipid metabolism of red sea bream. Bull Jpn Soc Sci Fish 52:1887–1893

    CAS  Google Scholar 

  284. Nakagawa H, Umino T, Tasaka Y (1997) Usefulness of Ascophyllum meal as a feed additive for red sea bream, Pagrus major. Aquaculture 151:275–281

    Google Scholar 

  285. Nakamura T, Nagayama K, Uchida K, Tanaka R (1996) Antioxidant activity of phlorotannins isolated from the brown alga Eisenia bicyclis. Fish Sci 62:923–926

    CAS  Google Scholar 

  286. Nakazawa Y, Sashima T, Hosokawa M, Miyashita K (2009) Comparative evaluation of growth inhibitory effect of stereoisomers of fucoxanthin in human cancer cell lines. J Funct Foods 1:88–97

    CAS  Article  Google Scholar 

  287. Narayan B, Miyashita K, Hosakawa M (2006) Physiological effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—a review. Food Rev Int 22:291–307

    CAS  Article  Google Scholar 

  288. Nasu T, Fukuda Y, Nagahira K, Kawashima H, Noguchi C, Nakanishi T (1997) Fucoidin, a potent inhibitor of L-selectin function, reduces contact hypersensitivity reaction in mice. Immunol Lett 59:47–51

    PubMed  CAS  Article  Google Scholar 

  289. Nishide E, Uchida H (2003) Effects of Ulva powder on the ingestion and excretion of cholesterol in rats. In: Chapman ARO, Anderson RJ, Vreeland VJ, Davison IR (eds) Proceedings of the 17th International Seaweed Symposium. Oxford University Press, Oxford, pp 165–168

    Google Scholar 

  290. Nishide E, Anzai H, Uchida N (1993) Effects of alginates on the ingestion and excretion of cholesterol in the rat. J Appl Phycol 5:207–211

    CAS  Article  Google Scholar 

  291. Nishino T, Nishioka C, Ura H, Nagumo T (1994) Isolation and partial characterization of a novel amino sugar-containing fucan sulfate from commercial Fucus vesiculosus fucoidan. Carbohydr Res 255:213–224

    PubMed  CAS  Article  Google Scholar 

  292. Nisizawa K (2002) Seaweed Kaiso, bountiful harvest from the seas. Sustenance for health and well-being by preventing common life-style related diseases. Kochi University, Kochi, 106 pp

    Google Scholar 

  293. Noa M, Mas R, Carbajal D, Valdes S (2000) Effect of D-002 on acetic acid-induced colitis in rats at single and repeated doses. Pharmacol Res 41:391–395

    PubMed  CAS  Article  Google Scholar 

  294. Noda H (1993) Health benefits and nutritional properties of nori. J Appl Phycol 5:255–258

    Article  Google Scholar 

  295. Okuzumi J, Takahashi T, Yamane T, Kitao Y, Inagake M, Ohya K, Nishino H, Tanaka Y (1993) Inhibitory effects of fucoxanthin, a natural carotenoid, on N-ethyl-N′-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis. Cancer Lett 68:159–168

    PubMed  CAS  Article  Google Scholar 

  296. Omata M, Matsui N, Inomata N, Ohno T (1997) Protective effects of polysaccharide fucoidin on myocardial ischemia–reperfusion injury in rats. J Cardiovasc Pharmacol 30:717–724

    PubMed  CAS  Article  Google Scholar 

  297. Ortiz J, Romero N, Robert P, Araya J, Lopez-Hernández J, Bozzo C, Navarrete E, Osorio A, Rios A (2006) Dietary fiber, amino acid, fatty acid and tocopherol contents of the edible seaweeds Ulva lactuca and Durvillaea antarctica. Food Chem 99:98–104

    CAS  Article  Google Scholar 

  298. Ostergaard C, Yieng-Kow RV, Benfield T, Frimodt-Moller N, Espersen F, Lundgren JD (2000) Inhibition of leukocyte entry into the brain by the selectin blocker fucoidin decreases interleukin-1 (IL-1) levels but increases IL-8 levels in cerebrospinal fluid during experimental pneumococcal meningitis in rabbits. Infect Immun 68:3153–3157

    PubMed  CAS  Article  Google Scholar 

  299. Panlasigui LN, Baello OQ, Dimatangal JM, Dumelod BD (2003) Blood cholesterol and lipid-lowering effects of carrageenan on human volunteers. Asia Pac J Clin Nutr 12:209–214

    PubMed  CAS  Google Scholar 

  300. Paradossi G, Cavalieri F, Chiessi E (2002) A conformational study on the algal polysaccharide ulvan. Macromolecules 35:6404–6411

    CAS  Article  Google Scholar 

  301. Park PJ, Heo SJ, Park EJ, Kim SK, Byun HG, Jeon BT, Jeon YJ (2005) Reactive oxygen scavenging effect of enzymatic extracts from Sargassum thunbergii. J Agric Food Chem 53:6666–6672

    PubMed  CAS  Article  Google Scholar 

  302. Parsons AF (1996) Recent developments in kainoid amino acid chemistry. Tetrahedron 52:4149–4174

    CAS  Article  Google Scholar 

  303. Pavia H, Åberg P (1996) Spatial variation in polyphenolic content of Ascophyllum nodosum (Fucales, Phaeophyta). Hydrobiologia 326/327:199–203

    Article  Google Scholar 

  304. Pavia H, Cervin G, Lindgren A, Åberg P (1997) Effects of UV-B radiation and simulated herbivory on phlorotannins in the brown alga Ascophyllum nodosum. Mar Ecol Prog Ser 157:139–146

    CAS  Article  Google Scholar 

  305. Pedersen M, Collen J, Abrahamsson K, Ekdahl A (1996) Production of halocarbons from seaweeds: an oxidative stress reaction? Sci Mar 60:257–263

    CAS  Google Scholar 

  306. Percival E, McDowell RH (1990) Algal polysaccharides. In: Dey PM (ed) Methods in plant biochemistry, volume 2: carbohydrates. Academic, London, pp 523–547

    Google Scholar 

  307. Perelló G, Martí-Cid R, Llobet JM, Domingo JL (2008) Effects of various cooking processes on the concentrations of arsenic, cadmium, mercury, and lead in foods. J Agric Food Chem 56:11262–11269

    PubMed  Article  CAS  Google Scholar 

  308. Plaza M, Cifuentes A, Ibáñez E (2008) In the search of new functional food ingredients from algae. Trends Food Sci Technol 19:31–39

    CAS  Article  Google Scholar 

  309. Plouguerne E, Hellio C, Deslandes E, Veron B, Stiger-Pouvreau V (2008) Anti-microfouling activities in extracts of two invasive algae: Grateloupia turuturu and Sargassum muticum. Bot Mar 51:202–208

    Article  Google Scholar 

  310. Population Council (2008) Trial shows anti-HIV microbicide is safe, but does not prove it effective. http://www.popcouncil.org/mediacenter/newsreleases/2008_CarraguardResults.asp on December 12 2010

  311. Qi HM, Zhang QB, Zhao TT, Chen R, Zhang H, Niu XZ, Li Z (2005a) Antioxidant activity of different sulfate content derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta) in vitro. Int J Biol Macromol 37:195–199

    PubMed  CAS  Article  Google Scholar 

  312. Qi HM, Zhao TT, Zhang QB, Li Z, Zhao ZQ, Xing R (2005b) Antioxidant activity of different molecular weight sulfated polysaccharides from Ulva pertusa Kjellm (Chlorophyta). J Appl Phycol 17:527–534

    CAS  Article  Google Scholar 

  313. Ragan MA, Jensen A (1978) Quantitative studies on brown algal phenols. II. Seasonal variation in polyphenol content of Ascophyllum nodosum (L.) Le Jol. and Fucus vesiculosus (L.). J Exp Mar Biol Ecol 34:245–258

    CAS  Article  Google Scholar 

  314. Ramsey UP, Bird CJ, Shacklock PF, Laycock MV, Wright JL (1994) Kainic acid and 1′-hydroxykainic acid from Palmariales. Nat Toxins 2:286–292

    PubMed  CAS  Article  Google Scholar 

  315. Rasmussen RS, Morrissey MT (2007) Marine biotechnology for production of food ingredients. In: Taylor SL (ed) Advances in food and nutrition research, vol 52. Elsevier, New York, pp 237–292

    Google Scholar 

  316. Reckitt and Colman Products Ltd (1999) Formulations for the treatment of gastro-oesophageal reflux. US Patent No. 6,348,502

  317. Reilly P, O’Doherty JV, Pierce KM, Callan JJ, O’Sullivan JT, Sweeney T (2008) The effects of seaweed extract inclusion on gut morphology, selected intestinal microbiota, nutrient digestibility, volatile fatty acid concentrations and the immune status of the weaned pig. Animal 2:1465–1473

    CAS  Article  Google Scholar 

  318. Renn DW, Noda H, Amano H, Nishino T, Nishizana K (1994a) Antihypertensive and antihyperlipidemic effects of funoran. Fish Sci 60:423–427

    Google Scholar 

  319. Renn DW, Noda H, Amano H, Nishino T, Nishizana K (1994b) Study on hypertensive and antihyperlipidemic effect of marine algae. Fish Sci 60:83–88

    Google Scholar 

  320. Reynolds JEF, Prasad AB (1982) Martindale the extra pharmacopoeia. 28th Pharmaceutical Press, London, 735 pp

  321. Riccardi BA, Fahrenbach MJ (1965) Effect of guar gum and pectin on serum and liver lipids of cholesterol-fed rats. Proc Soc Exp Biol Med 124:749–752

    Google Scholar 

  322. Rioux LE, Turgeon SL, Beaulieu M (2007) Characterization of polysaccharides extracted from brown seaweeds. Carbohydr Polym 69:530–537

    CAS  Article  Google Scholar 

  323. Robertson WV, Schwartz B (1953) Ascorbic acid and the formation of collagen. J Biol Chem 201:689–696

    Google Scholar 

  324. Robledo D, Freile-Pelegrín Y (1997) Chemical and mineral composition of six potentially edible seaweed species of Yucatan. Bot Mar 40:301–306

    CAS  Article  Google Scholar 

  325. Rocha de Souza M, Marques C, Guerra Dore C, Ferreira da Silva F, Oliveira Rocha H, Leite E (2007) Antioxidant activities of sulfated polysaccharides from brown and red seaweeds. J Appl Phycol 19:153–160

    PubMed  CAS  Article  Google Scholar 

  326. Rodrigueza MRC, Montaño MNE (2007) Bioremediation potential of three carrageenophytes cultivated in tanks with seawater from fish farms. J Appl Phycol 19:755–762

    CAS  Article  Google Scholar 

  327. Ronnberg O, Adjers K, Ruokolahti C, Bondestam M (1990) Fucus vesiculosus as an indicator of heavy metal availability in a fish farm recipient in the northern Baltic Sea. Mar Pollut Bull 21:388–392

    CAS  Article  Google Scholar 

  328. Rorrer GL, Yoo HD, Huang YM, Hayden C, Gerwick WH (1997) Production of hydroxy fatty acids by cell suspension cultures of the marine brown alga Laminaria saccharina. Phytochemistry 46:871–877

    CAS  Article  Google Scholar 

  329. Rupérez P (2002) Mineral content of edible marine seaweeds. Food Chem 79:23–26

    Article  Google Scholar 

  330. Rupérez P, Saura-Calixto F (2001) Dietary fibre and physicochemical properties of edible Spanish seaweeds. Eur Food Res Technol 212:349–354

    Article  Google Scholar 

  331. Ruperez P, Ahrazem O, Leal JA (2002) Potential antioxidant capacity of sulfated polysaccharides from the edible marine brown seaweed Fucus vesiculosus. J Agric Food Chem 50:840–845

    PubMed  CAS  Article  Google Scholar 

  332. Sailler B, Glombitza KW (1999) Phlorethols and fucophlorethols from the brown alga Cystophora retroflexa. Phytochemistry 50:869–881

    CAS  Article  Google Scholar 

  333. Sampath-Wiley P, Neefus CD, Jahnke LS (2008) Seasonal effects of sun exposure and emersion on intertidal seaweed physiology: fluctuations in antioxidant contents, photosynthetic pigments and photosynthetic efficiency in the red alga Porphyra umbilicalis Kützing (Rhodophyta, Bangiales). J Exp Mar Biol Ecol 361:83–91

    CAS  Article  Google Scholar 

  334. Sanchez-Machado DI, Lopez-Cervantes J, Lopez-Hernandez J, Paseiro-Losada P (2004a) Fatty acids, total lipid, protein and ash contents of processed edible seaweeds. Food Chem 85:439–444

    CAS  Article  Google Scholar 

  335. Sanchez-Machado DI, Lopez-Hernandez J, Paseiro-Losada P, Lopez-Cervantes J (2004b) An HPLC method for the quantification of sterols in edible seaweeds. Biomed Chromatogr 18:183–190

    PubMed  CAS  Article  Google Scholar 

  336. Sandau E, Sandau P, Pulz O, Zimmermann M (1996) Heavy metal sorption by marine algae and algae by-products. Acta Biotechnol 16:103–119

    CAS  Article  Google Scholar 

  337. Sathivel A, Raghavendran HRB, Srinivasan P, Devaki T (2008) Anti-peroxidative and anti-hyperlipidemic nature of Ulva lactuca crude polysaccharide on d-galactosamine induced hepatitis in rats. Food Chem Toxicol 46:3262–3267

    PubMed  CAS  Article  Google Scholar 

  338. Sato M, Hosokawa T, Yamaguchi T, Nakano T, Muramoto K, Kahara T, Funayama K, Kobayashi A, Nakano T (2002) Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats. J Agric Food Chem 50:6245–6252

    PubMed  CAS  Article  Google Scholar 

  339. Satoh K, Nakagawa H, Kasahara S (1987) Effect of Ulva meal supplementation on disease resistance of red sea bream. Nippon Suisan Gakkaishi 53:1115–1120

    Google Scholar 

  340. Savitskaya IM (1986) Trial of a local hemostatic with alginate base. Klin Khirurgiya 3:39–40

    Google Scholar 

  341. Schaeffer DJ, Krylov VS (2000) Anti-HIV activity of extracts and compounds from algae and cyanobacteria. Ecotoxicol Environ Saf 45:208–227

    PubMed  CAS  Article  Google Scholar 

  342. Segal HC, Hunt BJ, Gilding K (1998) The effects of alginate and non-alginate wound dressings on blood coagulation and platelet activation. J Biomater Appl 12:249–257

    PubMed  CAS  Google Scholar 

  343. Sekar S, Chandramohan M (2008) Phycobiliproteins as a commodity: trends in applied research, patents and commercialization. J Appl Phycol 20:113–136

    Article  Google Scholar 

  344. Sen AK, Das AK, Banerji N, Siddhanta AK, Mody KH, Ramavat BK, Chauhan VD, Vedasiromoni JR, Ganguly DK (1994) A new sulfated polysaccharide with potent blood anti-coagulant activity from the red seaweed Grateloupia Indica. Int J Biol Macromol 16:279–280

    PubMed  CAS  Article  Google Scholar 

  345. Shanmugam M, Mody KH (2000) Heparinoid-active sulphated polysaccharides from marine algae as potential blood anticoagulant agents. Curr Sci 79:1672–1683

    CAS  Google Scholar 

  346. Sheth BB (1967) Alginate containing antacid compositions. US Patent No. 3,326,755

  347. Shinagawa A, Shiomi K, Yamanaka H, Kicuchi T (1983) Selective determination of inorganic arsenic(III), (V) and organic arsenic in marine organisms. Bull Jpn Soc Sci Fish 49:75–78

    CAS  Google Scholar 

  348. Shiu CT, Lee TM (2005) Ultraviolet-B-induced oxidative stress and responses of the ascorbate–glutathione cycle in a marine macroalga Ulva fasciata. J Exp Bot 56:2851–2865

    PubMed  CAS  Article  Google Scholar 

  349. Sieburth JM, Conover JT (1965) Sargassum tannin, an antibiotic which retards fouling. Nature 208:52–53

    Google Scholar 

  350. Simpson FJ, Shacklock PF (1979) The cultivation of Chondrus crispus. Effect of temperature on growth and carrageenan production. Bot Mar 22:295–298

    Article  Google Scholar 

  351. Siriwardhana N, Lee KW, Kim SH, Ha JW, Jeon YJ (2003) Antioxidant activity of Hizikia fusiformis on reactive oxygen species scavenging and lipid peroxidation inhibition. Food Sci Technol Int 9:339–346

    Article  Google Scholar 

  352. Siriwardhana N, Lee KW, Kim SH, Ha JH, Park GT, Jeon YJ (2004) Lipid peroxidation inhibitory effects of Hizikia fusiformis methanolic extract on fish oil and linoleic acid. Food Sci Technol Int 10:65–72

    CAS  Article  Google Scholar 

  353. Skoler-Karpoff S, Ramjee G, Ahmed K, Altini L, Plagianos MG, Friedland B, Govender S, Kock AD, Cassim N, Palanee T et al (2008) Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial. Lancet 372:1977–1987

    PubMed  CAS  Article  Google Scholar 

  354. Slezka IE, Miroshichenko VA, Vostrikova OG, Ziganshina OA (1998) Applications of bioactive compounds from marine organisms in atherosclerosis prophylaxis in children, new biomedical technologies using bioactive additives. Proceedings of All Russian Conference. IMKVL Siberian Branch, Ross Akad Med Nauk, Vladivostok, pp 90–94

  355. Smit AJ (2004) Medicinal and pharmaceutical uses of seaweed natural products: a review. J Appl Phycol 16:245–262

    CAS  Article  Google Scholar 

  356. Smith DG, Young EG (1953) On the nitrogenous constituents of Fucus vesiculosus. J Biol Chem 205:849–858

    PubMed  CAS  Google Scholar 

  357. Soler-Vila A, Coughlan S, Guiry MD, Kraan S (2009) The red alga Porphyra dioica as a fish-feed ingredient for rainbow trout (Oncorhynchus mykiss): effects on growth, feed efficiency and carcass composition. J Appl Phycol 21:617–624

    Article  Google Scholar 

  358. Sørensen HO (2009) Marine phospholipids. Int Aqua Feed 12:14–15

    Google Scholar 

  359. Sæter EA, Jensen A (1957) Forsøk med tangmel som tilskuddsfôr til sau [Experiments with seaweed meal as supplement to rations for sheep—summary in English]. Norwegian Institute of Seaweed Research. Akademisk Trykningssentral, Blinder, Oslo. Report 17, pp 1–30

  360. Spieler R (2002) Seaweed compound’s anti-HIV efficacy will be tested in southern Africa. Lancet 359:1675

    PubMed  Article  Google Scholar 

  361. Stahl W, Sies H (2005) Bioactivity and protective effects of natural carotenoids. BBA-Mol Basis Disease 1740:101–107

    CAS  Article  Google Scholar 

  362. Stahl W, Ale-Agha N, Polidori MC (2002) Non-antioxidant properties of carotenoids. Biol Chem 383:553–558

    PubMed  CAS  Article  Google Scholar 

  363. Suetsuna K (1998a) Purification and identification of angiotensin I converting enzyme inhibitors from the red alga Porphyra yezoensis. J Mar Biotechnol 6:163–167

    PubMed  CAS  Google Scholar 

  364. Suetsuna K (1998b) Separation and identification of angiotensin I-converting enzyme inhibitory peptides from peptic digest of Hizikia fusiformis protein. Nippon Suisan Gakkaishi 64:862–866

    CAS  Google Scholar 

  365. Suetsuna K, Maekawa K, Chen JR (2004) Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats. J Nutr Biochem 15:267–272

    PubMed  CAS  Article  Google Scholar 

  366. Sugahara T, Ohama Y, Fukuda A, Hayashi M, Kawakubo A, Kato K (2001) The cytotoxic effect of Eucheuma serra agglutinin (ESA) on cancer cells and its application to molecular probe for drug delivery system using lipid vesicles. Cytotechnology 36:93–99

    PubMed  CAS  Article  Google Scholar 

  367. Sugawara T, Baskaran V, Tsuzuki W, Nagao A (2002) Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice. J Nutr 132:946–951

    PubMed  CAS  Google Scholar 

  368. Suzuki M, Daitoh M, Vairappan CS, Abe T, Masuda M (2002) Brominated metabolites from an Okinawan Laurencia intricate. Phytochemistry 60:861–867

    PubMed  CAS  Article  Google Scholar 

  369. Swinyard EA, Pathak MA (1985) Surface-acting drugs. In: Gilman AG, Goodman LS, Rall TW (eds) The pharmacological basis of therapeutics, 7th edn. Macmillan, New York, pp 946–958

    Google Scholar 

  370. Takahashi N, Ojika M, Dogasaki C, Nisizawa M, Fukuoka H, Sahara H, Sato N, Mori M, Kikuchi K (2000) Substance isolated from the kelp rhizoid identified as l-tryptophan shows high inhibition of breast cancer. Gan To Kagaku Ryoho 27:251–255

    PubMed  CAS  Google Scholar 

  371. Tasende MG (2000) Fatty acid and sterol composition of gametophytes and sporophytes of Chondrus crispus (Gigartinaceae, Rhodophyta). Sci Mar 64:421–426

    CAS  Article  Google Scholar 

  372. Terada A, Hara H, Mitsuoka T (1995) Effect of dietary alginate on the faecal microbiota and faecal metabolic activity in humans. Microb Ecol Health Dis 8:259–266

    Article  Google Scholar 

  373. Tititudorancea (2009) http://www tititudorancea com/z/nutrition_facts_undaria_spp_seaweed_wakame_raw htm, accessed 2 February 2009

  374. Tobacman JK (2001) Review of harmful gastrointestinal effects of carrageenan in animal experiments. Environ Health Perspect 109:983–994

    PubMed  CAS  Article  Google Scholar 

  375. Torsdottir I, Alpsten M, Holm G, Sandberg AS, Tolli J (1991) A small dose of soluble alginate-fiber affects postprandial glycemia and gastric-emptying in humans with diabetes. J Nutr 121:795–799

    PubMed  CAS  Google Scholar 

  376. Tseng CK (2001) Algal biotechnology industries and research activities in China. J Appl Phycol 13:375–380

    Article  Google Scholar 

  377. Tsuchiya Y (1969) Comparative hypocholesterolemic activities of marine algae. Proceeding of the International Seaweed Symposium 6:747–757

    Google Scholar 

  378. Urbano MG, Goñi I (2002) Bioavailability of nutrients in rats fed on edible seaweeds, nori (Porphyra tenera) and wakame (Undaria pinnatifida), as a source of dietary fibre. Food Chem 76:281–286

    CAS  Article  Google Scholar 

  379. Usov AI, Smirnova GP, Klochkova NG (2001) Polysaccharides of algae: 55. Polysaccharide composition of several brown algae from Kamchatka. Russ J Bioorgan Chem 27:395–399

    CAS  Article  Google Scholar 

  380. Vadas S, Wright WA, Beal BF (2004) Biomass and productivity of intertidal rockweeds (Ascophyllum nodosum LeJolis) in Cobscook Bay. Northeastern Naturalist 11:123–142

    Article  Google Scholar 

  381. Vairappan CS, Suzuki M, Abe T, Masuda M (2001) Halogenated metabolites with antibacterial activity from the Okinawan Laurencia species. Phytochemistry 58:517–523

    PubMed  CAS  Article  Google Scholar 

  382. Valente LMP, Gouveia A, Rema P, Matos J, Gomes EF, Pinto IS (2006) Evaluation of three seaweeds Gracilaria bursa-pastoris, Ulva rigida and Gracilaria cornea as dietary ingredients in European sea bass (Dicentrarchus labrax) juveniles. Aquaculture 252:85–91

    Article  Google Scholar 

  383. van de Velde F, Lourenco ND, Pinheiro HM, Bakker M (2002) Carrageenan: a food-grade and biocompatible support for immobilisation techniques. Adv Synth Catal 344:815–835

    Article  Google Scholar 

  384. van Netten C, Hoption Cann SA, Morley DR, van Netten JP (2000) Elemental and radioactive analysis of commercially available seaweed. Sci Total Environ 255:169–175

    PubMed  Article  Google Scholar 

  385. Vaugelade P, Hoebler C, Bernard F, Guillon F, Lahaye M, Duee PH, Darcy-Vrillon B (2000) Non-starch polysaccharides extracted from seaweed can modulate intestinal absorption of glucose and insulin response in the pig. Reprod Nutr Dev 40:33–47

    PubMed  CAS  Article  Google Scholar 

  386. Ventura MR, Castañón JIR (1998) The nutritive value of seaweed (Ulva lactuca) for goats. Small Rumin Res 29:325–327

    Article  Google Scholar 

  387. Verdrengh M, Erlandsson-Harris H, Tarkowski A (2000) Role of selectins in experimental Staphylococcus aureus-induced arthritis. Eur J Immunol 30:1606–1613

    PubMed  CAS  Article  Google Scholar 

  388. Vlieghe P, Clerc T, Pannecouque C, Witvrouw M, De Clercq E, Salles JP, Kraus JL (2002) Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities. J Med Chem 45:1275–1283

    PubMed  CAS  Article  Google Scholar 

  389. Voet D, Voet J, Pratt CW (1999) Fundamentals of biochemistry. Wiley, New York, 1095 pp

    Google Scholar 

  390. von Elbe JH, Schwartz SJ (1996) Colorants. In: Fennema OR (ed) Food chemistry. Marcel Dekker, New York, pp 651–722

    Google Scholar 

  391. Wahbeh MI (1997) Amino acid and fatty acid profiles of four species of macroalgae from Aqaba and their suitability for use in fish diets. Aquaculture 159:101–109

    CAS  Article  Google Scholar 

  392. Wang WT, Zhou JH, Xing ST (1994) Immunomodulating action of marine algae sulfated polysaccharides on normal and immunosuppressed mice. Chin J Pharm Toxicol 8:199–202

    CAS  Google Scholar 

  393. Wang GC, Sun HB, Fan X, Tseng CK (2002) Large-scale isolation and purification of R-phycoerythrin from red alga Palmaria palmata using the expanded bed adsorption method. Acta Bot Sin 44:541–546

    CAS  Google Scholar 

  394. Wang Y, Han F, Hu B, Li JB, Yu WG (2006) In vivo prebiotic properties of alginate oligosaccharides prepared through enzymatic hydrolysis of alginate. Nutr Res 26:597–603

    CAS  Article  Google Scholar 

  395. Wang J, Zhang QB, Zhang ZS, Li Z (2008) Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica. Int J Biol Macromol 42:127–132

    PubMed  Article  CAS  Google Scholar 

  396. Washington N, Denton G (1995) Effect of alginate and alginate–cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux. J Pharm Pharmacol 47:879–882

    PubMed  CAS  Article  Google Scholar 

  397. Weinberger F (2007) Pathogen-induced defense and innate immunity in macroalgae. Biol Bull 213:290–302

    PubMed  CAS  Article  Google Scholar 

  398. Wen X, Peng CL, Zhou HC, Lin ZF, Lin GZ, Chen SW, Li P (2006) Nutritional composition and assessment of Gracilaria lemaneiformis Bory. J Integr Plant Biol 48:1047–1053

    CAS  Article  Google Scholar 

  399. Whittaker MH, Frankos VH, Wolterbeek AMP, Waalkens-Berendsen DH (2000) Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis: clinical and experimental evidence. Am J Med 109:600–601

    PubMed  CAS  Article  Google Scholar 

  400. Wikipedia (2010) www.wikipedia.com, accessed 25 June 2010

  401. Witvrouw M, DeClercq E (1997) Sulfated polysaccharides extracted from sea algae as potential antiviral drugs. Gen Pharmacol Vasc Syst 29:497–511

    CAS  Google Scholar 

  402. Wong KH, Cheung PCK (2000) Nutritional evaluation of some subtropical red and green seaweeds. Part I—proximate composition, amino acid profiles and some physico-chemical properties. Food Chem 71:475–482

    CAS  Article  Google Scholar 

  403. Wong K, Cheung PC (2001a) Influence of drying treatment on three Sargassum species. 2. Protein extractability, in vitro protein digestibility and amino acid profile of protein concentrates. J Appl Phycol 13:51–58

    CAS  Article  Google Scholar 

  404. Wong K, Cheung PC (2001b) Influence of drying treatment on three Sargassum species. 1. Proximate composition, amino acid profile and some physico-chemical properties. J Appl Phycol 13:43–50

    CAS  Article  Google Scholar 

  405. Wong KH, Cheung PCK (2001c) Nutritional evaluation of some subtropical red and green seaweeds. Part II. In vitro protein digestibility and amino acid profiles of protein concentrates. Food Chem 72:11–17

    CAS  Article  Google Scholar 

  406. Wright AD, Goclik E, Konig GM (2003) Three new sesquiterpenes from the red alga Laurencia perforata. J Nat Prod 66:435–437

    PubMed  CAS  Article  Google Scholar 

  407. Wu XW, Yang ML, Huang XL, Yan J, Luo Q (2003) Effect of fucoidan on splenic lymphocyte apoptosis induced by radiation. Chin J Radiol Med Prot 23:43–50

    Google Scholar 

  408. Xu WJ, Liao XJ, Xu SH, Diao JZ, Du B, Zhou XL, Pan SS (2008) Isolation, structure determination, and synthesis of galaxamide, a rare cytotoxic cyclic pentapeptide from a marine algae Galaxaura filamentosa. Org Lett 10:4569–4572

    PubMed  CAS  Article  Google Scholar 

  409. Xue CH, Chen L, Li ZJ, Cai YP, Lin H, Fang Y (2004) Antioxidative activities of low molecular fucoidans from kelp Laminaria japonica. Dev Food Sci 42:139–145

    CAS  Article  Google Scholar 

  410. Yamamoto I, Takahashi M, Tamura E, Maruyama H, Mori H (1984) Antitumor-activity of edible marine-algae—effect of crude fucoidan fractions prepared from edible brown seaweeds against L-1210 leukemia. Hydrobiologia 116:145–148

    Article  Google Scholar 

  411. Yan XJ, Chuda Y, Suzuki M, Nagata T (1999) Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed. Biosci Biotechnol Biochem 63:605–607

    PubMed  CAS  Article  Google Scholar 

  412. Yan XJ, Zheng L, Chen HM, Lin W, Zhang WW (2004) Enriched accumulation and biotransformation of selenium in the edible seaweed Laminaria japonica. J Agric Food Chem 52:6460–6464

    PubMed  CAS  Article  Google Scholar 

  413. Yang XL, Sun JY, Xu HN (1995) An experimental study on immunoregulatory effect of fucoidan. Chin J Mar Drugs 14:909–913

    Google Scholar 

  414. Yasui A, Tsutsumi C, Toda S (1978) Selective determination of inorganic arsenic(III), (V) and organic arsenic in biological materials by solvent extraction atomic absorption spectrophotometry. Agric Biol Chem 42:2139–2145

    CAS  Article  Google Scholar 

  415. Ye H, Wang K, Zhou C, Liu J, Zeng X (2008) Purification, antitumor and antioxidant activities in vitro of polysaccharides from the brown seaweed Sargassum pallidum. Food Chem 111:428–432

    CAS  Article  Google Scholar 

  416. Ying P, Shakibaei M, Patankar MS, Clavijo P, Beavis RC, Clark GF, Frevert U (1997) The malaria circumsporozoite protein: Interaction of the conserved regions I and II-plus with heparin-like oligosaccharides in heparan sulfate. Exp Parasitol 85:168–182

    Google Scholar 

  417. Yone Y, Furuichi M, Urano K (1986) Effects of wakame Undaria pinnatifida and Ascophyllum nodosum on absorption of dietary nutrients, and blood sugar and plasma free amino-N levels of red sea bream. Bull Jpn Soc Sci Fish 52:1817–1819

    Google Scholar 

  418. Young EG, Smith DG (1958) Amino acids, peptides, and proteins of Irish moss, Chondrus crispus. J Biol Chem 233:406–410

    PubMed  CAS  Google Scholar 

  419. Yuan YV (2008) Marine algal constituents. In: Barrow C, Shahidi F (eds) Marine neutraceuticals and functional foods. CRC, Boca Raton, pp 297–320

    Google Scholar 

  420. Yuan YV, Walsh NA (2006) Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds. Food Chem Toxicol 44:1144–1150

    PubMed  CAS  Article  Google Scholar 

  421. Yuan YV, Carrington MF, Walsh NA (2005) Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro. Food Chem Toxicol 43:1073–1081

    PubMed  CAS  Article  Google Scholar 

  422. Zaragoza MC, Lopez D, Saiz MP, Poquet M, Perez J, Puig-Parellada P, Marmol F, Simonetti P, Gardana C, Lerat Y et al. (2008) Toxicity and antioxidant activity in vitro and in vivo of two Fucus vesiculosus extracts. J Agric Food Chem 56:7773–7780

  423. Zee S (1991) Body weight loss with the aid of alginic acid. Arc Intern Med 3-4:113–114

    Google Scholar 

  424. Zeitlin L, Whaley KJ, Hegarty TA, Moench TR, Cone RA (1997) Tests of vaginal microbicides in the mouse genital herpes model. Contraception 56:329–335

    PubMed  CAS  Article  Google Scholar 

  425. Zeitoun P, Salmon L, Bouche O, Jolly, D, Thiefin G (1998) Outcome of erosive/ulcerative reflux oesophagitis in 181 consecutive patients 5 years after diagnosis. Ital J Gastroenterol Hepatol 30:470–474

    Google Scholar 

  426. Zhang QB, Li N, Zhou GF, Lu XL, Xu ZH, Li Z (2003) In vivo antioxidant activity of polysaccharide fraction from Porphyra haitanesis (Rhodephyta) in aging mice. Pharmacol Res 48:151–155

    PubMed  CAS  Article  Google Scholar 

  427. Zhang JZ, Tiller C, Shen JK, Wang C, Girouard GS, Dennis D, Barrow CJ, Miao MS, Ewart HS (2007) Antidiabetic properties of polysaccharide- and polyphenolic-enriched fractions from the brown seaweed Ascophyllum nodosum. Can J Physiol Pharmacol 85:1116–1123

    PubMed  CAS  Article  Google Scholar 

  428. Zhao X, Xue CH, Li BF (2008) Study of antioxidant activities of sulfated polysaccharides from Laminaria japonica. J Appl Phycol 20:431–436

    CAS  Article  Google Scholar 

  429. Zhou G, Sheng W, Yao W, Wang C (2006a) Effect of low molecular [lambda]-carrageenan from Chondrus ocellatus on antitumor H-22 activity of 5-Fu. Pharmacol Res 53:129–134

    PubMed  CAS  Article  Google Scholar 

  430. Zhou Y, Yang HS, Hu HY, Liu Y, Mao YZ, Zhou H, Xu XL, Zhang FS (2006b) Bioremediation potential of the macroalga Gracilaria lemaneiformis (Rhodophyta) integrated into fed fish culture in coastal waters of North China. Aquaculture 252:264–276

    Article  Google Scholar 

  431. Zhuang C, Itoh H, Mizuno T, Ito H (1995) Antitumor active fucoidan from the brown seaweed, Umitoranoo (Sargassum thunbergii). Biosci Biotechnol Biochem 59:563–567

    PubMed  CAS  Article  Google Scholar 

  432. Zou Y, Qian ZJ, Li Y, Kim MM, Lee SH, Kim SK (2008) Antioxidant effects of phlorotannins isolated from Ishige okamurae in free radical-mediated oxidative systems. J Biotechnol 136:S579–S580

    Article  Google Scholar 

  433. Zubia M, Payri C, Deslandes E (2008) Alginate, mannitol, phenolic compounds and biological activities of two range-extending brown algae, Sargassum mangarevense and Turbinaria ornata (Phaeophyta: Fucales), from Tahiti (French Polynesia). J Appl Phycol 20:1033–1043

    Article  Google Scholar 

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Holdt, S.L., Kraan, S. Bioactive compounds in seaweed: functional food applications and legislation. J Appl Phycol 23, 543–597 (2011). https://doi.org/10.1007/s10811-010-9632-5

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Keywords

  • High value-added products
  • Health promotion
  • Biorefinery
  • Nutraceutical
  • Pharmaceutical
  • Feed supplement