Journal of Applied Phycology

, Volume 22, Issue 5, pp 599–605 | Cite as

Evaluation of the toxicity of Arthrospira (Spirulina) platensis extract

  • Nongporn Hutadilok-TowatanaEmail author
  • Wantana Reanmongkol
  • Pharkphoom Panichayupakaranant


In this study, the methanol extract of Arthrospira (Spirulina) platensis was examined for acute and subchronic toxicities. The extract did not produce any sign of toxicity within 7 days after feeding it at a single high dose of 6 g kg−1 body weight to female and male Swiss mice. For the subchronic toxicity test, the extract at doses of 6, 12, and 24 mg kg−1 body weight was orally administered to six male and six female Wistar rats daily for 12 weeks. Throughout the study period, we did not observe any abnormalities on behavior, food and water intakes, and health status among the treated animals. The hematology and clinical chemistry parameters of treated groups did not significantly differ from those of the controls in both sexes. Postmortem examination of the test groups also showed no abnormalities in both gross and histological findings. These results thus suggest that the methanol extract of A. platensis did not cause acute or subchronic toxicity in our experimental animals.


Acute toxicity Arthrospira platensis Blue-green algae Methanol extract Spirulina Subchronic toxicity 



This project was supported by the Royal Thai Government Budget (grant no. PHA 49127). Thanks are extended to Dr. Brian Hodgson for his suggestions and help in refining the manuscript. Appreciation also goes to Ms. Pratum Ritthisunthorn and Ms. Ruthaiwan Bunkrongcheap for their technical assistance.


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Nongporn Hutadilok-Towatana
    • 1
    • 2
    Email author
  • Wantana Reanmongkol
    • 3
  • Pharkphoom Panichayupakaranant
    • 4
  1. 1.Department of Biochemistry, Faculty of SciencePrince of Songkla UniversityHat YaiThailand
  2. 2.Natural Products Research Center, Faculty of SciencePrince of Songkla UniversityHat YaiThailand
  3. 3.Department of Clinical Pharmacy, Faculty of Pharmaceutical SciencesPrince of Songkla UniversityHat YaiThailand
  4. 4.Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical SciencesPrince of Songkla UniversityHat YaiThailand

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