Abstract
The Modified Checklist for Autism in Toddlers, Revised with Follow-up was validated on a population sample in Reykjavik, Iceland. The participants (N = 1585) were screened in well-child care at age 30 months and followed up for at least 2 years to identify autism cases. The sensitivity, specificity, positive and negative predictive values were 0.62, 0.99, 0.72, and 0.99, respectively. True-positive children were diagnosed 10 months earlier than false-negative children. Autism symptom severity and the proportions of children with verbal and performance IQs/DQs < 70 were similar between groups. Although the sensitivity was suboptimal, the screening contributed to lowering the age at diagnosis for many children. Adding autism-specific screening to the well-child care program should be considered.
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Acknowledgements
The authors would like to thank all the participating families and the clinicians at the participating centers for their collaboration and the directorates at the PHC and the SDCC for their support. We also want to thank Gyda S. Haraldsdottir for reviewing the files of the Center for Development and Behavior to identify cases.
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SLJ received a Grant from the Public Health Fund in Iceland (P-2019-10-14-0010).
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SLJ contributed to the conception and design of the study; coordinated the project; collected, analyzed, and interpreted the data; and wrote the first draft of the manuscript. ES and VR contributed to the conception and design of the study, interpreted the data, and helped draft the manuscript. BG provided a statistical consultation and participated in the data analysis and interpretation. All authors read and revised earlier drafts of the manuscript and approved the final version.
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Jonsdottir, S.L., Saemundsen, E., Jonsson, B.G. et al. Validation of the Modified Checklist for Autism in Toddlers, Revised with Follow-up in a Population Sample of 30-Month-Old Children in Iceland: A Prospective Approach. J Autism Dev Disord 52, 1507–1522 (2022). https://doi.org/10.1007/s10803-021-05053-1
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DOI: https://doi.org/10.1007/s10803-021-05053-1