Abstract
Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A1*28 (c.-41-40dup), UGT1A1*6 (c.211 G > A), and UGT1A1*27 (c.686 C > A). The allele frequency of UGT1A1*6 (OR = 1.34, p = 0.26) and UGT1A1*28 (OR = 0.80, p = 0.54) and the prevalence of UGT1A1*28/*6 diplotypes did not differ significantly from those in the control population. No UGT1A1*27 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A1*28/*6/*27 genotypes or UGT1A1*28/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD.
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Acknowledgments
We thank all staffs of the participating centers and hospital for collecting preserved dried umbilical cord samples. This study was supported in part by Grants-in-Aid for Scientific Research (KAKENHI) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Grant No. 17K16299 to KM). The present study was approved by the ethics committee at Kobe University Graduate School of Medicine (No. 170002).
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TH contributed to the design of the study, performed data collections and statistical analyses, and wrote the original draft. KM contributed to the design of the study, performed sample collections, and edited the original draft. MN, MM, YT, YO, TK, MN, YK, MY, HM, YN, JS, SF, KF, and KT performed sample and data collections. ST, HN, KN, and KI contributed to the design of the study and edited the manuscript. NN contributed to the design of the study, performed sample collections, and edited the original draft. All authors participated in the preparation of the manuscript and approved its final version.
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Horinouchi, T., Maeyama, K., Nagai, M. et al. Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children. J Autism Dev Disord 52, 483–489 (2022). https://doi.org/10.1007/s10803-021-04941-w
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DOI: https://doi.org/10.1007/s10803-021-04941-w