Skip to main content
SpringerLink
Log in

Recovery from Autism after Successful Surgery for a Benign Brain Tumor Associated with Epilepsy

  • Letter to the Editor
  • Published:
Journal of Autism and Developmental Disorders Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  • Adachi, K., Murai, Y., & Teramoto, A. (2012). Infantile cerebellar pilocytic astrocytoma with autism spectrum disorder. Journal of Nippon Medical School, 79, 228–231.

    Article  Google Scholar 

  • Amiet, C., Gourfinkel-An, I., Bouzamondo, A., Tordjman, S., Baulac, M., Lechat, P., et al. (2008). Epilepsy in autism is associated with intellectual disability and gender: Evidence from a meta-analysis. Biological Psychiatry, 64, 577–582.

    Article  Google Scholar 

  • Baron-Cohen, S., Ring, H. A., Bullmore, E. T., Wheelwright, S., Ashwin, C., & Williams, S. C. (2000). The amygdala theory of autism. Neuroscience and Biobehavioral Reviews, 24, 355–364.

    Article  Google Scholar 

  • Ben-Ari, Y., & Holmes, G. L. (2006). Effects of seizures on developmental processes in the immature brain. Lancet Neurology, 5, 1055–1063.

    Article  Google Scholar 

  • Brooks-Kayal, A. (2010). Epilepsy and autism spectrum disorders: Are there common developmental mechanisms? Brain and Development, 32, 731–738.

    Article  Google Scholar 

  • Christensen, D. L., Baio, J., Van Naarden Braun, K., Bilder, D., Charles, J., Constantino, J. N., et al. (2016). Prevalence and characteristics of autism spectrum disorder among children aged 8 years—Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012. Morbidity and Mortality Weekly Report Surveillance Summaries, 65(3), 1–23.

    PubMed  Google Scholar 

  • Flint, A. E., Waterman, M., Bowmer, G., Vadlamani, G., Chumas, P., & Morrall, M. C. H. J. (2017). Neuropsychological outcomes following paediatric temporal lobe surgery for epilepsies: Evidence from a systematic review. Seizure, 52, 89–116.

    Article  Google Scholar 

  • Helt, M., Kelley, E., Kinsbourne, M., Pandey, J., Boorstein, H., Herbert, M., & Fein, D. (2008). Can children with autism recover? If so, how? Neuropsychology Review, 18, 339–366.

    Article  Google Scholar 

  • Hoon, A. H., & Reiss, A. L. (1992). The mesial-temporal lobe and autism: Case report and review. Developmental Medicine and Child Neurology, 34, 252–265.

    Article  Google Scholar 

  • Hrdlicka, M., Komarek, V., Propper, L., Kulisek, R., Zumrova, A., Faladova, L., et al. (2004). Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism. European Child and Adolescent Psychiatry, 13, 209–213.

    Article  Google Scholar 

  • Lai, M. C., Lombardo, M. V., & Baron-Cohen, S. (2014). Autism. Lancet, 383, 896–910.

    Article  Google Scholar 

  • Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.

    Article  Google Scholar 

  • Lord, C., Rutter, M., & LeCouteur, A. (1994). Autism diagnostic interview—Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.

    Article  Google Scholar 

  • Mikati, M. A., El-Bitar, M. K., Najjar, M. W., Rbeiz, J. J., Barada, W. H., Najjar, V. F., et al. (2009). A child with refractory complex partial seizures, right temporal ganglioglioma, contralateral continuous electrical status epilepticus, and a secondary Landau–Kleffner autistic syndrome. Epilepsy and Behavior, 14, 411–417.

    Article  Google Scholar 

  • Minhas, H. M., Pescosolido, M. F., Schwede, M., Piasecka, J., Gaitanis, J., Tantravahi, U., et al. (2013). An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism spectrum disorder and cerebellar juvenile pilocytic astrocytoma. American Journal of Medical Genetics Part A, 161, 787–791.

    Article  Google Scholar 

  • Nicolson, R., DeVito, T. J., Vidal, C. N., Sui, Y., Hayashi, K. M., Drost, D. J., et al. (2006). Detection and mapping of hippocampal abnormalities in autism. Psychiatry Research, 148, 11–21.

    Article  Google Scholar 

  • Omar, A. O., Ahmad, A. E., El Bashir, H., & Al Jaber, M. J. (2009). Trisomy 13 in a 7-year-old girl with cerebellar tumor, eye abnormalities, and autistic features. American Journal of Medical Genetics Part A, 149, 1056–1057.

    Article  Google Scholar 

  • Shubrata, K. S., Sinha, S., Seshadri, S. P., Girimaji, S., Subbakrishna, D. K., & Srinath, S. (2015). Childhood autism spectrum disorders with and without epilepsy: Clinical implications. Journal of Child Neurology, 30, 476–482.

    Article  Google Scholar 

  • Strasser, L., Downes, M., Kung, J., Cross, J. H., & De Haan, M. (2018). Prevalence and risk factors for autism spectrum disorder in epilepsy: A systematic review and meta-analysis. Developmental Medicine and Child Neurology, 60, 19–29.

    Article  Google Scholar 

  • Viscidi, E. W., Triche, E. W., Pescosolido, M. F., McLean, R., Joseph, R. M., Spence, S. J., et al. (2013). Clinical characteristics of children with autism spectrum disorder and co-occuring epilepsy. PLoS One, 8, e67797.

    Article  Google Scholar 

  • World Health Organization. (1992). International Classification of Diseases (10th ed.). Geneva: WHO.

    Google Scholar 

Download references

Acknowledgments

Supported by the Ministry of Health of the Czech Republic (Grant no. 16-31754A and the Project for Conceptual Development of Research Organization 00064203, University Hospital Motol, Prague, Czech Republic), and by the Charles University (Progres Q15 program). The authors would like to thank Thomas Secrest, M.Sc. for his assistance with the English version of the manuscript.

Funding

The work on the article was supported by the Ministry of Health (Grant no. 16-31754A and the Project for Conceptual Development of Research Organization 00064203), and by the Progres Q15 program.

Author information

Authors and Affiliations

  1. Department of Child Psychiatry, Charles University Second Faculty of Medicine and University Hospital Motol, V Uvalu 84, 15006, Prague, Czech Republic

    Michal Hrdlicka, Marketa Mohaplova & Iva Dudova

  2. Department of Pediatric Neurology, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic

    Martin Kudr & Pavel Krsek

  3. Department of Neurosurgery, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic

    Michal Tichy

  4. Department of Radiology, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic

    Martin Kyncl

  5. Department of Pathology and Molecular Medicine, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic

    Josef Zamecnik

Authors
  1. Michal Hrdlicka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martin Kudr
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pavel Krsek
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michal Tichy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Martin Kyncl
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Josef Zamecnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Marketa Mohaplova
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Iva Dudova
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MH conceived the report. MH and MKu performed clinical examinations of the patient and drafted the manuscript; both authors contributed equally to the manuscript. PK assessed the patient, planned the neurosurgery, contributed to and commented on the drafts of the manuscript. MT performed the neurosurgery and contributed to the draft of the manuscript. MKy assessed the MRI scans and contributed to the draft of the manuscript. JZ assessed the histopathology of the tumor and contributed to the draft of the manuscript. MM and ID performed clinical examinations of the patient and commented on the drafts of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Michal Hrdlicka.

Ethics declarations

Conflict of interest

Author Michal Hrdlicka declares that he has no conflict of interest. Author Martin Kudr declares that he has no conflict of interest. Author Pavel Krsek declares that he has no conflict of interest. Author Michal Tichy declares that he has no conflict of interest. Author Martin Kyncl declares that he has no conflict of interest. Author Josef Zamecnik declares that he has no conflict of interest. Author Marketa Mohaplova declares that she has no conflict of interest. Author Iva Dudova declares that she has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors. Informed consent was obtained from parents of the reported child.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hrdlicka, M., Kudr, M., Krsek, P. et al. Recovery from Autism after Successful Surgery for a Benign Brain Tumor Associated with Epilepsy. J Autism Dev Disord 49, 5100–5104 (2019). https://doi.org/10.1007/s10803-019-03935-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10803-019-03935-z

Search

Navigation