Journal of Autism and Developmental Disorders

, Volume 48, Issue 5, pp 1523–1529 | Cite as

Association of Autism Spectrum Disorders and Inflammatory Bowel Disease

  • Maunoo Lee
  • Jayasree Krishnamurthy
  • Apryl Susi
  • Carolyn Sullivan
  • Gregory H. Gorman
  • Elizabeth Hisle-Gorman
  • Christine R. Erdie-Lalena
  • Cade M. Nylund
Original Paper


Autism spectrum disorders (ASD) and inflammatory bowel disease (IBD) both have multifactorial pathogenesis with an increasing number of studies demonstrating gut-brain associations. We aim to examine the association between ASD and IBD using strict classification criteria for IBD. We conducted a retrospective case-cohort study using records from the Military Health System database with IBD defined as having one encounter with an ICD-9-CM diagnostic code for IBD and at least one outpatient prescription dispensed for a medication to treat IBD. Children with ASD were more likely to meet criteria for Crohn’s disease (CD) and Ulcerative colitis (UC) compared to controls. This higher prevalence of CD and UC in children with ASD compared to controls confirms the association of ASD with IBD.


Autism spectrum disorders (ASD) Crohn’s disease (CD) Ulcerative colitis (UC) Inflammatory bowel disease (IBD) 



We would like to thank Kathleen Madden, Virginia Randall, and Kirk Jensen for providing assistance with reviewing and editing this manuscript. This study was completed with support from the Congressional Directed Medical Research Programs, Autism Research Award: W81XWH-12-2-0066. This project has been presented as a poster format at DDW (Digestive Disease Week) conference in Chicago, IL on May 9, 2017.

Author Contributions

ML, JK, AS, and CMN developed study concept. ML, GHG, EHG, CREL, and CMN established study design. ML performed literature review and prepared the draft with guidance from CMN. JK and AS processed the data with analysis of data by JK and acquisition of data by AS. ML, CS, and CMN interpreted the data. All authors contributed intellectually critical revisions of the manuscript. All authors reviewed the final manuscript and gave approval for publication.


The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Departments of the Air Force, Army, Navy, the Department of Defense, or the U.S. Government. Several of the authors are military service members or U.S. Government employees. This work was prepared as part of their official duties under Title 17 U.S.C. 101, which defines a United States Government work as a “work prepared by a military service member or employee of the United States Government as part of that person’s official duties.” Title 17 U.S.C. 105 provides that “Copyright protection under this title is not available for any work of the United States Government.”

Compliance with Ethical Standards

Conflict of interest

Other than the funding from the Congressional Directed Medical Research Programs, Autism Research Award: W81XWH-12-2-0066, all authors denied any conflicts of interest.

Ethical Approval

The study was reviewed and approved by the Uniformed Services University Institutional Review Board.

Supplementary material

10803_2017_3409_MOESM1_ESM.pdf (27 kb)
Supplementary material 1 (PDF 26 KB)
10803_2017_3409_MOESM2_ESM.pdf (149 kb)
Supplementary material 2 (PDF 148 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature (outside the USA) 2017

Authors and Affiliations

  • Maunoo Lee
    • 1
    • 2
    • 3
  • Jayasree Krishnamurthy
    • 1
  • Apryl Susi
    • 1
  • Carolyn Sullivan
    • 1
  • Gregory H. Gorman
    • 1
  • Elizabeth Hisle-Gorman
    • 1
  • Christine R. Erdie-Lalena
    • 1
  • Cade M. Nylund
    • 1
  1. 1.Department of Pediatrics, F. Edward Hebert School of MedicineUniformed Services University of the Health SciencesBethesdaUSA
  2. 2.San DiegoUSA
  3. 3.Internal Medicine, Naval Medical CenterSan DiegoUSA

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