Bone Mineral Density in Boys Diagnosed with Autism Spectrum Disorder: A Case-Control Study
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This study compared bone mineral density (BMD) of the spine obtained by dual-energy X-ray absorptiometry (DEXA), nutritional status, biochemical markers, and gastrointestinal (GI) symptoms in 4–8 year old boys with Autism Spectrum Disorder (ASD) with a group of age-matched, healthy boys without ASD. Boys with ASD had significantly lower spine BMD compared to controls but this was not correlated with any biochemical markers, dietary intake of calcium and vitamin D, elimination diet status, or GI symptomology. Reduced BMD in 4–8 year old boys with ASD appears to involve factors other than nutrient intake and GI status, and requires further study.
KeywordsBone mineral density Autism spectrum disorder Nutrition Gastrointestinal symptoms Gluten-free/casein-free diet Vitamin D
We are very grateful to all the families that participated in this research study. We would particularly like to thank Anissa Ryland, Morgan Devlin, Nichole Roatch, Tiffany Maudlin, Tony Phelan, Michael Rotko, Hannah Somerville, Meg Glausser, Sean Goetz, and all the support staff and clinicians at The Johnson Center for Child Health and Development, for assistance with implementing this study. Funding was provided by The Johnson Center for Child Health and Development.
KB and LH conceived the study, participated in its design and coordination, interpreted the data, and drafted the manuscript; LR, AG, RS and CS participated in the design of the study and performed the measurements; WR and AP participated in the design and coordination of the study and collected data; and CNM performed the statistical analysis, assisted in the interpretation of the data, and helped draft the manuscript. All authors read and approved the final manuscript.
Compliance with Ethical Standards
Conflict of interest
All of the authors declare that they have no conflicts of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants, or participant’s representative (parent), included in the study and according to the above-mentioned principles.
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