Brief Report: The Negev Hospital-University-Based (HUB) Autism Database

Abstract

Elucidating the heterogeneous etiologies of autism will require investment in comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established a hospital-university-based (HUB) database of autism which incorporates prospective and retrospective data from a large and ethnically diverse population. The collected data includes social-demographic characteristics, standardized behavioral testing, detailed clinical history from electronic patient records, genetic samples, and various neurological measures. We describe the initial cohort characteristics following the first 18 months of data collection (188 children with autism). We believe that the Negev HUB autism database offers a unique and valuable resource for studying the heterogeneity of autism etiologies across different ethnic populations.

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Acknowledgments

This study was supported by a generous anonymous donation, a donation from Ann Berger, in memory of her father Daniel Falkner, the Israeli Science Foundation (ISF Grant 527/15), and by the Joyce and Irving Goldman Family foundation for research excellence. In addition, we want to thank to Mr. Suleiman Abu-Hani for his assistance in the Bedouin Families recruitment, and to all the families of children with autism who gave their consent to participate in this study.

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Contributions

Study conception and design: GM, ID, and IM. Acquisition of data: GM, ID, AM, HF, MI, MF, AB, LM, DS, LLY, ND, HG, SA, and IM. Analysis and interpretation of data: GM, ID, DS, AB, and IM. Drafting of manuscript: ​GM, ID, and IM. Critical revision: GM, ID, and IM.

Corresponding author

Correspondence to Idan Menashe.

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Conflict of interest

Gal Meiri, Nadav Davidovitch, and Idan Menashe has received a research grant from the Israeli Science Foundation (Grant Number 527/15). Ilan Dinstein, Analya Michaelowski, Hagit Flusser, Michal Ilan, Michal Faroy, Asif Bar-Sinai, Liora Manelis, Dana Stolowicz, Lili Lea Yosef, Hava Golan, and Shosh Arbelle declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Gal Meiri and Ilan Dinstein have contributed equally.

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Meiri, G., Dinstein, I., Michaelowski, A. et al. Brief Report: The Negev Hospital-University-Based (HUB) Autism Database. J Autism Dev Disord 47, 2918–2926 (2017). https://doi.org/10.1007/s10803-017-3207-0

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Keywords

  • Autism
  • Epidemiology
  • Multidisciplinary
  • Child development
  • Preschool psychiatry