A Prospective Study of the Concordance of DSM-IV and DSM-5 Diagnostic Criteria for Autism Spectrum Disorder

  • Micah O. Mazurek
  • Frances Lu
  • Heather Symecko
  • Eric Butter
  • Nicole M. Bing
  • Rachel J. Hundley
  • Marie Poulsen
  • Stephen M. Kanne
  • Eric A. Macklin
  • Benjamin L. Handen
Original Paper

Abstract

The transition from DSM-IV to DSM-5 criteria for autism spectrum disorder (ASD) sparked considerable concern about the potential implications of these changes. This study was designed to address limitations of prior studies by prospectively examining the concordance of DSM-IV and final DSM-5 criteria on a consecutive sample of 439 children referred for autism diagnostic evaluations. Concordance and discordance were assessed using a consistent diagnostic battery. DSM-5 criteria demonstrated excellent overall specificity and good sensitivity relative to DSM-IV criteria. Sensitivity and specificity were strongest for children meeting DSM-IV criteria for autistic disorder, but poor for those meeting criteria for Asperger’s disorder and pervasive developmental disorder. Higher IQ, older age, female sex, and less pronounced ASD symptoms were associated with greater discordance.

Keywords

Autism spectrum disorder DSM-5 Concordance Sensitivity Specificity 

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Micah O. Mazurek
    • 1
    • 2
  • Frances Lu
    • 3
  • Heather Symecko
    • 3
    • 4
  • Eric Butter
    • 5
  • Nicole M. Bing
    • 6
  • Rachel J. Hundley
    • 7
  • Marie Poulsen
    • 8
  • Stephen M. Kanne
    • 1
  • Eric A. Macklin
    • 3
    • 9
  • Benjamin L. Handen
    • 10
  1. 1.Department of Health Psychology, Thompson Center for Autism and Neurodevelopmental DisordersUniversity of MissouriColumbiaUSA
  2. 2.Curry School of EducationUniversity of VirginiaCharlottesvilleUSA
  3. 3.Biostatistics CenterMassachusetts General HospitalBostonUSA
  4. 4.Besser Center for BRCA, Abramson Cancer CenterUniversity of PennsylvaniaPhiladelphiaUSA
  5. 5.Department of Pediatrics and Psychology, Nationwide Children’s HospitalThe Ohio State UniversityColumbusUSA
  6. 6.Division of Developmental and Behavioral PediatricsCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  7. 7.Division of Developmental Medicine, Department of PediatricsVanderbilt University Medical CenterNashvilleUSA
  8. 8.Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  9. 9.Department of MedicineHarvard Medical SchoolBostonUSA
  10. 10.Department of PsychiatryUniversity of Pittsburgh School of MedicinePittsburghUSA

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