Journal of Autism and Developmental Disorders

, Volume 47, Issue 6, pp 1628–1644 | Cite as

Autism Spectrum Disorder Symptoms in Infants with Fragile X Syndrome: A Prospective Case Series

  • Abigail L. Hogan
  • Kelly E. Caravella
  • Jordan Ezell
  • Lisa Rague
  • Kimberly Hills
  • Jane E. Roberts
Original Paper

Abstract

No studies to date have prospectively examined early autism spectrum disorder (ASD) markers in infants with fragile X syndrome (FXS), who are at elevated risk for ASD. This paper describes the developmental profiles of eight infants with FXS from 9 to 24 months of age. Four meet diagnostic criteria for ASD at 24 months of age, and four do not. Trends in these case studies suggest that early social-communicative deficits differentiate infants with and without later ASD diagnoses in ways that are similar to later-born siblings of children with ASD. Repetitive behaviors and cognitive and adaptive impairments are present in all FXS infants throughout development, suggesting that these deficits reflect the general FXS phenotype and not ASD in FXS specifically.

Keywords

Fragile X syndrome Autism spectrum disorder Infants Case studies 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Abigail L. Hogan
    • 1
  • Kelly E. Caravella
    • 1
  • Jordan Ezell
    • 1
  • Lisa Rague
    • 1
  • Kimberly Hills
    • 1
  • Jane E. Roberts
    • 1
  1. 1.Department of PsychologyUniversity of South CarolinaColumbiaUSA

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