Journal of Autism and Developmental Disorders

, Volume 46, Issue 9, pp 3106–3114

Mothers of Children with Autism have Different Rates of Cancer According to the Presence of Intellectual Disability in Their Child

  • Jennifer C. Fairthorne
  • Nicholas H. de Klerk
  • Helen M. Leonard
  • Andrew J. O. Whitehouse
Original Paper

DOI: 10.1007/s10803-016-2847-9

Cite this article as:
Fairthorne, J.C., de Klerk, N.H., Leonard, H.M. et al. J Autism Dev Disord (2016) 46: 3106. doi:10.1007/s10803-016-2847-9

Abstract

Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental disorders with strong genetic components. Increasingly, research attention has focused on whether genetic factors conveying susceptibility for these conditions, also influence the risk of other health conditions, such as cancer. We examined the occurrence of hospital admissions and treatment/services for cancer in mothers of children with ASD with or without ID compared with other mothers. After linking Western Australian administrative health databases, we used Cox regression to estimate the hazard ratios (HRs) of any hospitalisations and treatment/services for cancer in these groups of mothers. Mothers of children with ASD without ID had greater risk of admissions for cancer (HR 1.29 [95 % CI 1.1, 1.7]), and for treatment/services in particular (HR 1.41 [95 % CI 1.0, 2.0]), than mothers of children with no ASD/ID, while mothers of children with ASD with ID were no more likely to have a cancer-related hospital admission than other mothers. Mothers of children with autism without ID had increased risk of cancer, which may relate to common genetic pathways.

Keywords

Autism Intellectual disability Cancer Parents Genetics 

Supplementary material

10803_2016_2847_MOESM1_ESM.docx (14 kb)
Supplementary material 1 (DOCX 14 kb)

Funding information

Funder NameGrant NumberFunding Note
Australian National Health and Medical Research Council Program Grant
  • #572742
Australian National Health and Medical Research Council Senior Research Fellowship
  • #1077966

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Jennifer C. Fairthorne
    • 1
    • 2
  • Nicholas H. de Klerk
    • 1
  • Helen M. Leonard
    • 1
  • Andrew J. O. Whitehouse
    • 1
  1. 1.Telethon Kids InstituteUniversity of Western AustraliaPerthAustralia
  2. 2.Child and Family Research InstituteUniversity of British ColumbiaVancouverCanada

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