Executive Functions in Older Adults With Autism Spectrum Disorder: Objective Performance and Subjective Complaints
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Although deficits in Executive Functioning (EF) are reported frequently in young individuals with Autism Spectrum Disorders (ASD), they remain relatively unexplored later in life (>50 years). We studied objective performance on EF measures (Tower of London, Zoo map, phonetic/semantic fluency) as well as subjective complaints (self- and proxy reported BRIEF) in 36 ASD and 36 typically developed individuals (n = 72). High functioning older adults with ASD reported EF-impairments in metacognition, but did not deviate in EF task performance, except for a longer execution time of the Tower of London. The need for additional time to complete daily tasks may contribute to impairments in daily life and may be correlated to a higher level of experienced EF-difficulties in ASD.
KeywordsAutism spectrum disorder Neuropsychological assessment Cognition Executive function Processing speed Aging
The authors are grateful to all the participants who took part in this study, to the students who assisted with data collection and to Francien M. Kok, PhD, for editing the manuscript for language.
RD conceived of the study, participated in its design and coordination, performed the measurement, performed the statistical analysis and the interpretation of the data and drafted the manuscript; YG participated in its design and the coordination, helped with the acquisition, the statistical analysis and the interpretation of the data and helped to draft the manuscript; IJB participated in the design and interpretation of the data and revised the manuscript critically; OT participated in the design and revised the manuscript critically; IDCvB participated in its design, the interpretation of data, revised the manuscript critically and helped to draft the manuscript. All authors read and approved the final manuscript.
Compliance with Ethical Standards
Conflict of Interest
Roeliena C. D. Davids, Yvonne Groen, Ina J. Berg, Oliver M. Tucha and Ingrid D. C. van Balkom declares that she has no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.Google Scholar
- American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.Google Scholar
- Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from asperger syndrome/high-functioning autism, malesand females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1), 5–17.CrossRefPubMedGoogle Scholar
- Bastiaansen, J. A., Meffert, H., Hein, S., Huizinga, P., Ketelaars, C., Pijnenborg, M., et al. (2011). Diagnosing autism spectrum disorders in adults: The use of Autism Diagnostic Observation Schedule (ADOS) module 4. Journal of Autism and Developmental Disorders, 41(9), 1256–1266.CrossRefGoogle Scholar
- Benton, A. L., Hamsher, K., & Sivan, A. B. (1983). Multilingual aphasia examination (3rd ed.). Iowa City, IA: AJA Associates.Google Scholar
- Berger, H. J., Aerts, F. H., Spaendonck, K. P. V., Cools, A. R., & Teunisse, J. P. (2003). Central coherence and cognitive shifting in relation to social improvement in high-functioning young adults with autism. Journal of Clinical and Experimental Neuropsychology, 25(4), 502–511.CrossRefPubMedGoogle Scholar
- Bramham, J., Ambery, F., Young, S., Morris, R., Russell, A., Xenitidis, K., & Murphy, D. (2009). Executive functioning differences between adults with attention deficit hyperactivity disorder and autistic spectrum disorder in initiation, planning and strategy formation. Autism, 13(3), 245–264.CrossRefPubMedGoogle Scholar
- Constantino, J. N., Davis, S. A., Todd, R. D., Schindler, M. K., Gross, M. M., Brophy, S. L., & Reich, W. (2003). Validation of a brief quantitative measure of autistic traits: Comparison of the social responsiveness scale with the autism diagnostic interview-revised. Journal of Autism and Developmental Disorders, 33(4), 427–433.CrossRefPubMedGoogle Scholar
- De Luca, C. R., & Leventer, R. J. (2008). Developmental trajectories of executive functions across the lifespan. In V. Anderson, R. Jacobs, & P. J. Anderson (Eds.), Executive functions and the frontal lobes: A lifespan perspective (pp. 23–47). Abingdon: Psychology Press.Google Scholar
- Desjardins-Crépeau, L., Berryman, N., Vu, T. T. M., Villalpando, J. M., Kergoat, M. J., Li, K. Z., & Bherer, L. (2014). Physical functioning is associated with processing speed and executive functions in community-dwelling older adults. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 69(6), 837–844.CrossRefGoogle Scholar
- Durak, S., Ercan, E. S., Ardic, U. A., Yuce, D., Ercan, E., & Ipci, M. (2014). Effect of methylphenidate on neurocognitive test battery: An evaluation according to the diagnostic and statistical manual of mental disorders, subtypes. Journal of Clinical Psychopharmacology, 34(4), 467–474.CrossRefPubMedGoogle Scholar
- Granader, Y., Wallace, G. L., Hardy, K. K., Yerys, B. E., Lawson, R. A., Rosenthal, M., & Schultz, R. T. (2014). Characterizing the factor structure of parent reported executive function in autism spectrum disorders: The impact of cognitive inflexibility. Journal of Autism and Developmental Disorders, 44(12), 3056–3062.CrossRefPubMedGoogle Scholar
- Kenworthy, L., Anthony, L. G., Naiman, D. Q., Cannon, L., Wills, M. C., Luong-Tran, C., & Sokoloff, J. L. (2014). Randomized controlled effectiveness trial of executive function intervention for children on the autism spectrum. Journal of Child Psychology and Psychiatry, 55(4), 374–383.CrossRefPubMedGoogle Scholar
- Ketelaars, C., Horwitz, E., Sytema, S., Bos, J., Wiersma, D., Minderaa, R., & Hartman, C. A. (2008). Brief report: Adults with mild autism spectrum disorders (ASD): Scores on the autism spectrum quotient (AQ) and comorbid psychopathology. Journal of Autism and Developmental Disorders, 38(1), 176–180.CrossRefPubMedGoogle Scholar
- Krabbendam, L., & Kalff, A. C. (1997). BADS Behavioural Assessment of the Dysexecutive Syndrome. Dutch translation.Google Scholar
- Kretschmer, A., Altgassen, M., Rendell, P. G., & Bölte, S. (2014). Prospective memory in adults with high-functioning autism spectrum disorders: Exploring effects of implementation intentions and retrospective memory load. Research in Developmental Disabilities, 35(11), 3108–3118.CrossRefPubMedGoogle Scholar
- Lezak, M. D., Howieson, D. B., Bigler, E. D., & Tranel, D. (2012). Neuropsychological Assessment (5th ed.). Oxford: Oxford University Press.Google Scholar
- Lord, C., Risi, S., Lambrecht, L., Cook Jr, E. H., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule—generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.CrossRefPubMedGoogle Scholar
- Marshall, G. A., Rentz, D. M., Frey, M. T., Locascio, J. J., Johnson, K. A., Sperling, R. A., & Initiative, Alzheimer’s Disease Neuroimaging. (2011). Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer’s disease. Alzheimer’s & Dementia, 7(3), 300–308.CrossRefGoogle Scholar
- Nydén, A., Niklasson, L., Ståhlberg, O., Anckarsäter, H., Dahlgren-Sandberg, A., Wentz, E., & Råstam, M. (2010a). Adults with Asperger syndrome with and without a cognitive profile associated with “non-verbal learning disability”. A brief report. Research in Autism Spectrum Disorders, 4(4), 612–618.CrossRefGoogle Scholar
- Oliveras-Rentas, R. E., Kenworthy, L., Roberson, R. B, I. I. I., Martin, A., & Wallace, G. L. (2012). WISC-IV profile in high-functioning autism spectrum disorders: impaired processing speed is associated with increased autism communication symptoms and decreased adaptive communication abilities. Journal of Autism and Developmental Disorders, 42(5), 655–664.CrossRefPubMedPubMedCentralGoogle Scholar
- Ozonoff, S., Cook, I., Coon, H., Dawson, G., Joseph, R. M., Klin, A., & Rogers, S. J. (2004). Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism network. Journal of Autism and Developmental Disorders, 34(2), 139–150.CrossRefPubMedGoogle Scholar
- Pugliese, C. E., Anthony, L., Strang, J. F., Dudley, K., Wallace, G. L., & Kenworthy, L. (2014). Increasing adaptive behavior skill deficits from childhood to adolescence in autism spectrum disorder: Role of executive function. Journal of Autism and Developmental Disorders, 45(6), 1579–1587.CrossRefGoogle Scholar
- Pugliese, C. E., Anthony, L. G., Strang, J. F., Dudley, K., Wallace, G. L., Naiman, D. Q., & Kenworthy, L. (2016). Longitudinal examination of adaptive behavior in autism spectrum disorders: Influence of executive function. Journal of Autism and Developmental Disorders, 46, 467–477.CrossRefPubMedGoogle Scholar
- Roth, R. M., Isquith, P. K., & Gioia, G. A. (2005). Behavior rating inventory of executive function-adult version (BRIEF-A). Lutz, FL: Psychological Assessment Resources.Google Scholar
- Scholte, E., & Noens, I. (2011). BRIEF-A. Vragenlijst over executieve functies bij volwassenen. status: published.Google Scholar
- Spek, A. A., Scholte, E. M., & Van Berckelaer-Onnes, I. A. (2011). Local information processing in adults with high functioning autism and Asperger syndrome: The usefulness of neuropsychological tests and self-reports. Journal of Autism and Developmental Disorders, 41(7), 859–869.CrossRefPubMedGoogle Scholar
- Tucha, O., & Lange, K. W. (2004). The tower of London—German version. Göttingen: Hogrefe.Google Scholar
- Van den Bergh, S. F., Scheeren, A. M., Begeer, S., Koot, H. M., & Geurts, H. M. (2014). Age related differences of executive functioning problems in everyday life of children and adolescents in the autism spectrum. Journal of Autism and Developmental Disorders, 44(8), 1959–1971.CrossRefPubMedGoogle Scholar
- Van Der Elst, W., Van Boxtel, M. P., Van Breukelen, G. J., & Jolles, J. (2006). Normative data for the animal, profession and letter M naming verbal fluency tests for Dutch speaking participants and the effects of age, education, and sex. Journal of the International Neuropsychological Society, 12(01), 80–89.PubMedGoogle Scholar
- Verhage, F. (1964). Intelligence and age. Assen: Van Gorcum.Google Scholar
- Wallace, G. L., Kenworthy, L., Pugliese, C. E., Popal, H. S., White, E. I., Brodsky, E., & Martin, A. (2016). Real-world executive functions in adults with autism spectrum disorder: Profiles of impairment and associations with adaptive functioning and co-morbid anxiety and depression. Journal of Autism and Developmental Disorders, 46, 1071–1083.CrossRefPubMedGoogle Scholar
- Wechsler, D. (2008). Wechsler adult intelligence scale–Fourth Edition (WAIS–IV). San Antonio, TX: NCS Pearson.Google Scholar
- Wechsler, D. (2012). WAIS-IV-NL: Wechsler Adult Intelligence Scale-Fourth Edition-Nederlandstalige bewerking: Technische handleiding en Afname en scoringshandleiding [Technical Manual and Administration and Scoring Manual]. Amsterdam: Pearson Assessments and Information B.V.Google Scholar
- Williams, D. L., Minshew, N. J., & Goldstein, G. (2015). Further understanding of complex information processing in verbal adolescents and adults with autism spectrum disorders. Autism, 1362361315586171.Google Scholar
- Wilson, B. A., Alderman, N., Burgess, P., Emslie, H., & Evans, J. J. (1996). Behavioural assessment of the dysexecutive syndrome. Bury St. Edmunds, Suffolk: Thames Valley Test Company.Google Scholar