Validation of the Movie for the Assessment of Social Cognition in Adolescents with ASD: Fixation Duration and Pupil Dilation as Predictors of Performance
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Impaired social cognition is one of the core characteristics of autism spectrum disorders (ASD). Appropriate measures of social cognition for high-functioning adolescents with ASD are, however, lacking. The Movie for the Assessment of Social Cognition (MASC) uses dynamic social stimuli, ensuring ecological validity, and has proven to be a sensitive measure in adulthood. In the current study, 33 adolescents with ASD and 23 controls were administered the MASC, while concurrent eye tracking was used to relate gaze behavior to performance levels. The ASD group exhibited reduced MASC scores, with social cognition performance being explained by shorter fixation duration on eyes and decreased pupil dilation. These potential diagnostic markers are discussed as indicators of different processing of social information in ASD.
KeywordsAutism spectrum disorder Eye-tracking Adolescence Pupil dilation Social cognition Ecological validity
The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under Grant Agreement No 115300, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and EFPIA companies’ in kind contribution. The current study is part of the first author’s doctoral dissertation. Parts of the results of the current study will be presented at the 9. Conference of the Society for Research in Autism Spectrum Conditions (WGAS) in Freiburg, Germany.
NM conceived of the study, participated in the study's design and coordination, performed the measurement and statistical analysis, and drafted the manuscript. SB participated in its design and coordination, performed the measurement, and helped to draft the manuscript. ID participated in its design and helped to draft the manuscript. TB participated in its design and helped to draft the manuscript. LP conceived of the study, participated in its design and interpretation of the data, and helped to draft the manuscript. All authors read and approved the final manuscript.
Compliance with Ethical Standards
Conflict of interest
Prof. Dr. Poustka received conference attendance support or was paid for public speaking by Lilly, Shire and Medice. She received research funding from EU, German Research Foundation (DFG), Federal Ministry of Education and Research (BMBF). Prof. Dr. Dr. Banaschewski served in an advisory or consultancy role for Actelion, Hexal Pharma, Lilly, Medice, Novartis, Oxford outcomes, PCM scientific, Shire and Viforpharma. He received conference support or speaker’s fee by Medice, Novartis and Shire. He is/has been involved in clinical trials conducted by Shire & Viforpharma. Their present work is unrelated to the above grants and relationships. Prof. Dr. Isabel Dziobek receives royalties for the Swedish version of the MASC from Hans Huber Publishers. Dr. Sarah Baumeister and Nico Müller declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- Baron-Cohen, S. (1995). Mindblindness: An essay on autism and theory of mind. Cambridge, MA: The MIT Press.Google Scholar
- Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001a). The “Reading the Mind in the Eyes” test revised version: A study with normal adults, and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry, 42(2), 241–251. doi: 10.1111/1469-7610.00715.CrossRefPubMedGoogle Scholar
- Baron-Cohen, S., Wheelwright, S., Spong, A., Scahill, V., & Lawson, J. (2001b). Are intuitive physics and intuitive psychology independent? A test with children with Asperger Syndrome. Journal of Developmental and Learning Disorders, 5(1), 47–78.Google Scholar
- Beatty, J., & Lucero-Wagoner, B. (2000). The pupillary system. Handbook of Psychophysiology, 2, 142–162.Google Scholar
- Bölte, S., Rühl, D., Schmötzer, G., & Poustka, F. (2006). Diagnostisches Interview für Autismus—Revidiert. Deutsche Fassung des Autism Diagnostic Interview—Revised von Michael Rutter. Ann LeCouteur und Catherine Lord. Verlag Hans Huber: Bern.Google Scholar
- Campbell, D. J., Shic, F., Macari, S., & Chawarska, K. (2014). Gaze response to dyadic bids at 2 years related to outcomes at 3 years in autism spectrum disorders: A subtyping analysis. Journal of Autism and Developmental Disorders, 44(2), 431–442. doi: 10.1007/s10803-013-1885-9.CrossRefPubMedPubMedCentralGoogle Scholar
- Chevallier, C., Parish-Morris, J., McVey, A., Rump, K. M., Sasson, N. J., Herrington, J. D., & Schultz, R. T. (2015). Measuring social attention and motivation in autism spectrum disorder using eye-tracking: Stimulus type matters. Autism Research, 8(5), 620–628. doi: 10.1002/aur.1479.CrossRefPubMedGoogle Scholar
- Constantino, J. N., & Gruber, C. P. (2005). Social Responsiveness Scale. Los Angeles: Western Psychological Services.Google Scholar
- Constantino, J. N., & Gruber, C. P. (2007). Social Responsiveness Scale (SRS-2) (Vol. 2). Los Angeles: Western Psychological Services.Google Scholar
- Falck-Ytter, T., von Hofsten, C., Gillberg, C., & Fernell, E. (2013b). Visualization and analysis of eye movement data from children with typical and atypical development. Journal of Autism and Developmental Disorders, 43(10), 2249–2258. doi: 10.1007/s10803-013-1776-0.CrossRefPubMedPubMedCentralGoogle Scholar
- Fletcher, T. D. (2010). Psychometric: Applied Psychometric Theory. R package version 2.2. Retrieved from http://CRAN.R-project.org/package=psychometric.
- Fletcher, T. D. (2012). QuantPsyc: Quantitative Psychology Tools. R package version 1.5.Google Scholar
- Fox, J., & Weisberg, S. (2011). An R companion to applied regression. Thousand Oaks, CA: Sage.Google Scholar
- Jones, W., Carr, K., & Klin, A. (2008). Absence of preferential looking to the eyes of approaching adults predicts level of social disability in 2-year-old toddlers with autism spectrum disorder. Archives of General Psychiatry, 65(8), 946–954. doi: 10.1001/archpsyc.65.8.946.CrossRefPubMedGoogle Scholar
- Klin, A., Jones, W., Schultz, R., & Volkmar, F. (2003). The enactive mind, or from actions to cognition: Lessons from autism. Philosophical Transactions of the Royal Society of London. Series B, Biological sciences, 358(1430), 345–360. doi: 10.1098/rstb.2002.1202.CrossRefPubMedPubMedCentralGoogle Scholar
- Klin, A., Jones, W., Schultz, R., Volkmar, F., & Cohen, D. (2002). Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism. Archives of General Psychiatry, 59(9), 809–816. doi: 10.1001/archpsyc.59.9.809.CrossRefPubMedGoogle Scholar
- Krach, S., Kamp-Becker, I., Einhäuser, W., Sommer, J., Frässle, S., Jansen, A., et al. (2015). Evidence from pupillometry and fMRI indicates reduced neural response during vicarious social pain but not physical pain in autism. Human Brain Mapping, 36(11), 4730–4744. doi: 10.1002/hbm.22949.CrossRefPubMedGoogle Scholar
- Lord, C., Risi, S., Lambrecht, L., Cook, E. H, Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The Autism Diagnostic Observation Schedule—Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.CrossRefPubMedGoogle Scholar
- Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. L. (2012). Autism diagnostic observation schedule: ADOS-2. Los Angeles: Western Psychological Services.Google Scholar
- Martineau, J., Hernandez, N., Hiebel, L., Roché, L., Metzger, A., & Bonnet-Brilhault, F. (2011). Can pupil size and pupil responses during visual scanning contribute to the diagnosis of autism spectrum disorder in children? Journal of Psychiatric Research, 45(8), 1077–1082.CrossRefPubMedGoogle Scholar
- Petermann, U., & Petermann, F. (2011). WISC-IV: Wechsler Intelligence Scale for Children-: Deutschsprachige Adaptation nach D Wechsler. Amsterdam: Pearson Assessment and Information.Google Scholar
- Preißler, S., Dziobek, I., Ritter, K., Heekeren, H. R., & Roepke, S. (2010). Social cognition in borderline personality disorder: Evidence for disturbed recognition of the emotions, thoughts, and intentions of others. Frontiers in behavioral neuroscience, 4(182), 1–8.Google Scholar
- Prifitera, A., Saklofske, D. H., & Weiss, L. G. (2005). WISC-4 clinical use and interpretation. Burlington, MA: Elsevier Academic Press.Google Scholar
- R Core Team. (2014). R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. https://cran.r-project.org/doc/FAQ/R-FAQ.html.
- Raiford, S., Weiss, L., Rolfhus, E., & Coalson, D. (2005). WISC-IV technical report# 4: General Ability Index. Upper Saddle River, NJ: Pearson Education Inc.Google Scholar
- Revelle, W. (2015). Psych: Procedures for personality and psychological research. Evanston, Illinois: Northwestern University.Google Scholar
- Robin, X., Turck, N., Hainard, A., Tiberti, N., Lisacek, F., Sanchez, J. C., & Müller, M. (2011). pROC: An open-source package for R and S + to analyze and compare ROC curves. (Vol. 12).Google Scholar
- Rühl, D., Bölte, S., Feineis-Matthews, S., & Poustka, F. (2004). Diagnostische Beobachtungsskala für Autistische Störungen (ADOS). Bern: Verlag Hans Huber.Google Scholar
- Rutter, M., Le Couteur, A., Lord, C., & Faggioli, R. (2005). ADI-R: Autism diagnostic interview–revised: Manual. Los Angeles: Western Psychological Services.Google Scholar
- Tabachnick, B. G., & Fidell, L. S. (2001). Using multivariate statistics. Boston, MA: Allyn and Bacon.Google Scholar
- Tobii Technology. (2012). User manual–Tobii Studio. Manual Version 3.2 Rev A. 11/2012: Tobii Technology AB.Google Scholar
- Torchiano, M. (2015). Effsize: Efficient Effect Size Computation. R package version 0.5.4.Google Scholar
- van der Geest, J. N., Kemner, C., Verbaten, M. N., & van Engeland, H. (2002). Gaze behavior of children with pervasive developmental disorder toward human faces: A fixation time study. Journal of Child Psychology and Psychiatry, 43(5), 669–678. doi: 10.1111/1469-7610.00055.CrossRefPubMedGoogle Scholar
- Wang, S., Jiang, M., Duchesne, Xavier M., Laugeson, Elizabeth A., Kennedy, Daniel P., Adolphs, R., et al. (2015). Atypical visual saliency in autism spectrum disorder quantified through model-based eye tracking. Neuron, 88(3), 604–616. doi: 10.1016/j.neuron.2015.09.042.CrossRefPubMedPubMedCentralGoogle Scholar
- Wechsler, D. (2004). The Wechsler intelligence scale for children-fourth edition. London: Pearson Assessment.Google Scholar
- Woerner, W., Becker, A., Friedrich, C., Rothenberger, A., Klasen, H., & Goodman, R. (2002). Normierung und Evaluation der deutschen Elternversion des Strengths and Difficulties Questionnaire (SDQ): Ergebnisse einer repräsentativen Felderhebung. Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, 30(2), 105–112. doi: 10.1024//1422-4918.104.22.168.CrossRefPubMedGoogle Scholar
- Yi, L., Fan, Y., Quinn, P. C., Feng, C., Huang, D., Li, J., & Lee, K. (2013). Abnormality in face scanning by children with autism spectrum disorder is limited to the eye region: Evidence from multi-method analyses of eye tracking data. Journal of vision, 13(10), 5.CrossRefPubMedPubMedCentralGoogle Scholar