Association Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis
- 1k Downloads
As the link between maternal obesity and risk of autism among offspring is unclear, the present study assessed this association. A systematic search of an electronic database was performed to identify observational studies that examined the association between maternal obesity and autism. The outcome measures were odds ratios comparing offspring autism risk between obese and normal-weight mothers. Five observational studies were included in the meta-analysis. A fixed-effects model was used since low heterogeneity was observed between studies. The pooled adjusted odds ratio was 1.47 (95 % CI 1.24–1.74). The meta-analysis results support an increased risk of autism spectrum disorder in children of women who were obese during pregnancy. However, further study is warranted to confirm these results.
KeywordsMaternal obesity Autism spectrum disorder Offspring Meta-analysis
Ya-Min Li and Si-Yuan Tang conceived and designed the experiments. Jian-Jun Ou, Li Liu and Dan Zhang performed the experiments. Ya-Min Li, Jing-Ping Zhao and Si-Yuan Tang analyzed the data. Ya-Min Li and Jian-Jun Ou contributed software, hardware and analysis tools. Ya-Min Li, Jing-Ping Zhao and Si-Yuan Tang wrote the paper.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
Informed consent was obtained from all individual participants included in the study.
Research Involving Human Participants and/or Animals
This article does not contain any studies with human participants performed by any of the authors.
- American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Association.Google Scholar
- Atladóttir, H. Ó., Thorsen, P., Østergaard, L., Schendel, D. E., Lemcke, S., Abdallah, M., & Parner, E. T. (2010). Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. Journal of Autism and Developmental Disorders, 40(12), 1423–1430.PubMedCrossRefGoogle Scholar
- CDC. (2014). Prevalence of autism spectrum disorders among children aged 8 years: Autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summaries, 63(2), 1–22.Google Scholar
- Eidelman, A. I., & Samueloff, A. (2002) The pathophysiology of the fetus of the diabetic mother. Seminars in perinatology. Elsevier (pp 232–236).Google Scholar
- Kim, Y. S., Fombonne, E., Koh, Y. J., Kim, S. J., Cheon, K. A., & Leventhal, B. L. (2014). A comparison of DSM-IV pervasive developmental disorder and DSM-5 autism spectrum disorder prevalence in an epidemiologic sample. Journal of the American Academy of Child and Adolescent Psychiatry, 53(5), 500–508.PubMedPubMedCentralCrossRefGoogle Scholar
- Man, K. K., Tong, H. H., Wong, L. Y., Chan, E. W., Simonoff, E., & Wong, I. C. (2015). Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: A systematic review and meta-analysis of observational studies. Neuroscience and Biobehavioral Reviews, 49C, 82–89.CrossRefGoogle Scholar
- Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 921–929.PubMedCrossRefGoogle Scholar
- Wells, G., Shea, B., O’Connell, D., Peterson, J., Welch, V., & Losos, M. (2013) The Newcastle–Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses 2009.Google Scholar