Journal of Autism and Developmental Disorders

, Volume 46, Issue 1, pp 342–351

Re-conceptualizing ASD Within a Dimensional Framework: Positive, Negative, and Cognitive Feature Clusters


DOI: 10.1007/s10803-015-2539-x

Cite this article as:
Foss-Feig, J.H., McPartland, J.C., Anticevic, A. et al. J Autism Dev Disord (2016) 46: 342. doi:10.1007/s10803-015-2539-x


Introduction of the National Institute of Mental Health’s Research Domain Criteria and revision of diagnostic classification for Autism Spectrum Disorder in the latest diagnostic manual call for a new way of conceptualizing heterogeneous ASD features. We propose a novel conceptualization of ASD, borrowing from the schizophrenia literature in clustering ASD features along positive, negative, and cognitive dimensions. We argue that this dimensional conceptualization can offer improved ability to classify, diagnose, and treat, to apply and predict response to treatment, and to explore underlying neural and genetic alterations that may contribute to particular feature clusters. We suggest the proposed conceptualization can advance the field in a manner that may prove clinically and biologically useful for understanding and addressing heterogeneity within ASD.


Autism spectrum disorder Symptoms Heterogeneity Classification Diagnosis RDoC 

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Yale University Child Study CenterNew HavenUSA
  2. 2.Department of PsychiatryYale UniversityNew HavenUSA

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